JP7433908B2 - セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物、製造、および使用 - Google Patents
セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物、製造、および使用 Download PDFInfo
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- JP7433908B2 JP7433908B2 JP2019558768A JP2019558768A JP7433908B2 JP 7433908 B2 JP7433908 B2 JP 7433908B2 JP 2019558768 A JP2019558768 A JP 2019558768A JP 2019558768 A JP2019558768 A JP 2019558768A JP 7433908 B2 JP7433908 B2 JP 7433908B2
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- yarrow
- fresh plant
- skin
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- juice concentrate
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- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 235000015192 vegetable juice Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 description 1
- 229940100530 zinc ricinoleate Drugs 0.000 description 1
- 229910052984 zinc sulfide Inorganic materials 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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Description
本発明はまた、セイヨウノコギリソウの使用の新たな態様にも関する。本発明は、皮膚細胞における熱ショックタンパク質および/または抗菌ペプチドの発現を刺激するためのセイヨウノコギリソウの使用を提供する。さらに、皮膚の熱耐性を増大するためのセイヨウノコギリソウの使用が記載される。
セイヨウノコギリソウは、抽出物の形態で使用される。液状抽出物の製造のために、例えば、フレッシュな(乾燥されていない)植物が使用され、すなわち、一般に出発植物材料は製造区域の近くで培養または採取されなければならない。成熟した植物が収穫され、かつ腐敗および微生物汚染を予防するために、タイミングよく(通常、1日以内に)圧搾されかつ瓶詰めされなければならない。
この方法で得られたセイヨウノコギリソウ圧搾汁は、例えば、膨満感および食欲不振を含む、消化管における軽度の痙攣性不快感に対して使用され得る。セイヨウノコギリソウはまた、その創傷治癒における好ましい特性により、スキンクリームにも使用される。
セイヨウノコギリソウフレッシュ植物圧搾汁の工業的製造は、圧搾する植物または植物部位を収穫し、清浄化し、切り刻み、植物酵素の不活性化および植物材料の分解のための水蒸気処理、加圧下での圧搾、ろ過または遠心分離、滅菌のための超高温短時間加熱および無菌充填により、一般的に行われる(Deutsche Apothekerzeitung 2011, p. 93 ff.)。こうしたフレッシュ植物圧搾汁は、通常、2~6質量%の乾燥抽出物または乾燥汁を含む。これは、高温が短時間しか使用されない、穏やかなプロセスである。さらに、比較的少ない作業ステップしか必要としない。これは、抗酸化剤などの敏感で生物学的に活性な成分を確実に保護するためである。
したがって、本発明は、100質量%のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物に対して、
10~100質量%のセイヨウノコギリソウフレッシュ植物圧搾汁乾燥残渣、
0~90質量%の水、および
0~90質量%の担体
を含むかまたはからなる、セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物に関する。
セイヨウノコギリソウフレッシュ植物圧搾汁を準備するステップ、および
セイヨウノコギリソウフレッシュ植物圧搾汁を濃縮するステップ、
のステップを含むかまたはステップからなる、セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物、好ましくは本明細書に記載の本発明の濃縮物を製造する方法に関する。
本発明は、皮膚細胞において熱ショックタンパク質および/または抗菌ペプチドの発現を刺激するためのセイヨウノコギリソウの使用を提供する。
本発明はさらに、皮膚の熱耐性を増大するためのセイヨウノコギリソウの使用を提供する。
さらに、本発明は、本発明のフレッシュ植物圧搾汁濃縮物の医薬としての使用に関する。
これら方法の1つまたは複数の使用は、蒸留による水の除去などの、フレッシュ植物圧搾汁の濃縮のための好ましくない慣行を防ぐことができる。蒸留による水の除去は昇温下(70~80℃)でのより長いプロセス時間を必要とし、通常、成分プロファイルの変化につながる。熱に敏感な成分は、これにより、変化するかまたは分解されることがある。
セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物は、例えば、セイヨウノコギリソウフレッシュ植物圧搾汁から、濃縮プロセスによって製造されてよい。例えば、セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物は、Schoenenberger社のセイヨウノコギリソウフレッシュ植物圧搾汁から、濃縮によって製造される。しかし、いかなるセイヨウノコギリソウ抽出物、特にセイヨウノコギリソウフレッシュ植物圧搾汁も使用することができることが明らかである。
好ましいのは、10~50質量%のセイヨウノコギリソウフレッシュ植物圧搾汁乾燥残渣、0~90質量%の水、0~50質量%の担体、および0~3質量%の保存剤および/または安定化剤を含む液体セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物である。固体または液体セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の利点は、簡潔かつ費用効率の良い製造、良好な保存性、容易な取扱いおよび投与、ならびに、所望されれば、標準化である。
化粧用組成物、特に皮膚および毛髪のクレンジングおよびケアのための化粧用組成物、における(固体または液体)セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の用量は、0.0001~10質量%、好ましくは0.001~5質量%、特に好ましくは0.005~3質量%である。
一実施形態によれば、担体は、固体担体、特に、マルトデキストリン、デキストリンまたはシクロデキストリン、および/または液体担体、特に、グリセロール、プロピレングリコール、ブチレングリコール、1,3-プロパンジオール、1,2-ペンタンジオール、1,2-ヘキサンジオールまたは1,2-オクタンジオールである。
1つまたはいくつかの担体が含まれてよいことは明らかである。これらの担体は、固体または液体(25℃および1013ミリバールにおいて)であってよい。各々の物質または物質の混合物は担体として使用されてよい。
デンプンの分解の度合いは、通常、指標「デキストロース当量」(DE)によって示され、この指標は長鎖グルコースポリマーに対して0の閾値かつ純粋グルコースに対して100の閾値を有する。多糖、特に、5~20の範囲のDE値、好ましくは15~20の範囲DE値をもつマルトデキストリンが、やはり特に有利である。
好ましい液体担体の例は、エタノール、ジアセチン、イソプロピルアルコール、グリセロール、1,2-プロピレングリコール、1,3-プロパンジオール、1,3-ブチレングリコール、トリアセチンおよびそれらの混合物である。
一実施形態によれば、セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物は、さらに、保存剤および/または安定化剤を含む。
いかなる数の保存剤および/または安定化剤が使用されてもよい。
本発明の状況において使用される保存剤は、通常、以下の特性のいくつか、好ましくは全てを有する。それらは、毒物学的に無害であり、皮膚の忍容性良好であり、安定で、本質的に完全に無臭であり、かつ容易にかつ費用が掛からずに(すなわち容易に入手可能な抽出物から)製造できる。保存剤はまた、抗菌特性をも有する。適切な保存剤は、例えば、WO2006/045743において見られる。
さらに、フェニルヒドロキシアルキルエーテル、特にフェノキシエタノールとして知られる化合物は、いくつかの微生物に対するその殺菌および殺真菌効果のために、保存剤として適している。
適切な安定化剤はまた、例えば、DE29924656、DE69917811、DE69624799、EP2952103(欧州特許出願公開第2952103号)およびDE69518581から採り上げることができる。
一実施形態によれば、セイヨウノコギリソウフレッシュ植物圧搾汁は、<60℃の温度で濃縮される。
一実施形態によれば、セイヨウノコギリソウフレッシュ植物圧搾汁は、フリーズドライ、噴霧乾燥および逆浸透、またはこれらの組合せから選択される濃縮プロセスによって濃縮される。これらのプロセスは、技術水準において周知である。
これらの濃縮物を微生物汚染から守ることもまた有利である。これは、例えば、pH値を下げることおよび/または前述のような適切な保存剤の添加によって達成することができる。
凍結乾燥または昇華乾燥とも称されるフリーズドライは、費用集約的で比較的複雑ではあるが、極度に穏やかなプロセスである。フリーズドライは、昇華の物理的プロセスに基づいている:このプロセスにより氷の結晶が、中間に液相の出現を伴わずに、直接、気体状態へと昇華する。本事例において、フリーズドライは、保存剤の添加がなくても十分に貯蔵できる固体を生成する。フリーズドライの手順は、例えば、GB1447988およびDE19817177から採り上げることができる。
セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物は、好ましくは本発明の方法によって得ることができる。
本発明の濃縮物はヒト用化粧品およびケア、特に皮膚および毛髪のケア、において幅広い範囲の適用を有するが、また、医薬用として、ならびに食品および補助食品においても使用することができる。
化粧用組成物は、特に、皮膚化粧用、毛髪化粧用、皮膚科学的および衛生用組成物であってよい。特に、本発明の濃縮物は、皮膚および/または毛髪化粧品に使用される。
一般に、毛髪または皮膚化粧用調製物は、皮膚または毛髪への適用のために使用される。「局所用調製物」は、活性成分を、細かく分散させた形態、例えば皮膚から吸収される形態で、皮膚に塗布するのに適した調製物を意味する。適切なものは、例えば、水性および水性アルコール溶液、スプレー、フォーム、フォームエアロゾル、軟膏、水性ゲル、O/W型またはW/O型のエマルション、マイクロエマルションまたは化粧用スティック調製物である。
本発明の組成物の製造において、本発明に従って使用される構成要素または活性成分は、通常、賦形剤で混合されるかまたは希釈される。賦形剤は、濃縮物中に含まれる活性成分のビヒクル、担体または媒体として働く、固体、半固体または液体材料であってよい。活性物質の(本発明に従って同時に含まれる1つまたはいくつかの活性物質の)含有量は、幅広い範囲にわたって変動してよい。
したがって、本発明の組成物はまた、通常の添加剤または賦形剤に加えて、(さらに)美容上および/または皮膚科学的におよび/または薬理学的に活性な剤を含んでよい。
さらなる適切な添加剤は、香油、ヘアポリマー、毛髪および皮膚コンディショナー、グラフトポリマー、水溶性または分散性シリコーン含有ポリマー、光防御剤、漂白剤、ケア剤、染色剤、色付け剤、タンニング剤、染料、粘稠性向上剤、湿潤剤、加脂肪剤、コラーゲン、タンパク質加水分解物、脂質、抗酸化剤、消泡剤、帯電防止剤、エモリエント剤、可塑剤、過酸化物分解剤から選択される。
適切な賦形剤および添加剤の例として、抗酸化剤、過酸化物分解剤、増粘剤および上述の保存剤を挙げることができる。
増粘剤の例は、架橋ポリアクリル酸およびそれらの誘導体、キサンタンガムなどの多糖およびそれらの誘導体、アガーアガー、アルギネートまたはチロース、セルロース誘導体、例えばカルボキシメチルセルロースまたはヒドロキシカルボキシメチルセルロース、脂肪アルコール、モノグリセリドおよび脂肪酸、ポリビニルアルコールおよびポリビニルピロリドンである。特に、非イオン性増粘剤が使用される。
いかなるUV-AおよびUV-Bフィルター物質も、UVフィルター物質とみなすことができる。言及できる例は:
適切な充血性物質もまた、化粧用または医薬組成物に含まれてよい。充血性物質は、皮膚の血液循環を刺激する。例は、マウンテンパイン抽出物、ラベンダー抽出物、ローズマリー抽出物、ジュニパーベリー抽出物、マロニエ抽出物、バーチ葉抽出物、ヘイフラワー抽出物、酢酸エチル、カンフル、メントール、ペパーミント油、ローズマリー抽出物、ユーカリ油、などの精油である。
角質溶解および角質形成物質もまた含まれてよい。こうした物質の例には、サリチル酸、チオグリコール酸カルシウム、チオグリコール酸およびそれらの塩、イオウなどが含まれる。適切な抗フケ剤はイオウ、イオウポリエチレングリコール、ソルビタンモノオレエート、イオウリシノールポリエトキシレート、亜鉛ピリチオン、アルミニウムピリチオンなどである。
皮膚刺激を和らげる適切な消炎剤は、例えば、アラントイン、ビザボロール、ドラゴサントール(dragosantol)、カモミール抽出物、パンテノールなどである。
適切なポリマーはまた、非イオン性、水溶性または水分散性ポリマーまたはオリゴマー、例えば、ポリビニルカプロラクタム、例えばLuviskol(登録商標)Plus(BASF)、またはポリビニルピロリドンおよびそれらのコポリマー、特に酢酸ビニルなどのビニルエステルとのコポリマー、例えば、B.Luviskol(登録商標)VA37(BASF)、ポリアミド、例えばイタコン酸および脂肪族ジアミンベースのもの、例えばDE-A-4333238に記載のようなものなどである。
本発明のさらなる課題は、本発明の濃縮物を含む食品または補助食品に関する。
製品が補助食品である場合、製品は一般に、純粋な包装材料以外に、いかなる他の添加物をも伴うことなく使用される。マクロカプセルまたはマイクロカプセルは、好ましい適用形態である。マクロカプセルは好ましくは、ゼラチンからなるか、あるいは多糖またはデキストリンをベースとして含む噴霧乾燥製品である。
一実施形態によれば、化粧用組成物または医薬組成物は、0.01~10質量%の皮膚鎮静剤および/または抗酸化剤をさらに含む。
局所用組成物に適切な皮膚鎮静剤またはエモリエント剤の例には、ビサボロール、アラントイン、メントール、ショ糖、センテラ抽出物、カンゾウ抽出物、ファルネソール、ルスカス抽出物、ゼニアオイ抽出物、ジャスミン抽出物、ローズマリー酸およびローズマリー酸を含む植物抽出物、カラスムギ抽出物、ショウガ抽出物、[6]-パラドール、ハマメリス抽出物、カレンデュラ抽出物、アルニカ抽出物、エキナセア抽出物、水添ポリイソブテン、C12-C15安息香酸アルコール、ミリスチン酸イソプロピル、鉱油、ラノリンおよびラノリン誘導体、例えばココナツ油などのトリグリセリド、セトステアリルアルコール、セチルアルコール、パルミチン酸イソプロピル、カプリル酸/カプリン酸トリグリセリド、PPG-2ミリスチルエーテルプロピオネート、ジメチコン、メチコン、ワセリンおよび当業者に周知の他の皮膚鎮静剤が含まれる。
一実施形態によれば、セイヨウノコギリソウの使用は、皮膚細胞における熱ショックタンパク質(HSP)および/または抗菌ペプチド(AMP)の発現を刺激するために提供される。
HSP27は、低分子熱ショックタンパク質(sHSP)に属する。HSP27は、ストレス誘導性のタンパク質凝集を防ぐATP-非依存性分子シャペロンである。Hsp27は、無傷の皮膚、主として表皮の顆粒層および有棘層において見られる。
一実施形態によれば、皮膚の熱耐性を増大するためのセイヨウノコギリソウの使用が提供される。
一実施形態によれば、セイヨウノコギリソウはセイヨウノコギリソウフレッシュ植物圧搾汁としてまたは本発明に従った使用における化粧用組成物として使用される。
一実施形態によれば、本発明に従って使用される場合、化粧用組成物中のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の用量は、100質量%の化粧用組成物に対して0.0001~10質量%である。
好ましくは、化粧用組成物、特に皮膚および毛髪のクレンジングおよびケアのための化粧用組成物、におけるセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の用量は、0.001~5質量%、より好ましくは0.005~3質量%である。
一実施形態によれば、本発明の医薬組成物は、医薬として使用される。
本発明の医薬組成物はまた、癌予防および皮膚疾患の治療において使用されてよい。
一実施形態によれば、セイヨウノコギリソウが本発明に従って使用されるかまたは医薬組成物が本発明に従って医薬として使用される場合、皮膚および/または毛髪への局所適用が行われる。
本発明の文脈において、用語「consisting of(からなる)」は、網羅的な列挙を言い、明確に言及された構成要素またはステップから離れた他のいかなる構成要素またはステップをも除外する。
本発明の文脈において、用語「essentially consisting of(から基本的になる)」は、部分的に網羅的な列挙を言い、指定された構成要素に加えて、組成物の特徴を実質的に変化させないか、または組成物の特徴を実質的に変化させない量で存在するような追加の構成要素のみを含む組成物を言う。
フリーズドライによるセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の製造
独国において栽培された開花中のハーブから製造された、100mlのセイヨウノコギリソウ(Achillea millefollium)フレッシュ植物圧搾汁(Schoenenberger社)を凍結し、続いてフリーズドライする。5.3gの乾燥汁1aが、褐色-緑色固体として得られ、その組成を分析する:
結果は、セイヨウノコギリソウ(Achillea millefollium)フレッシュ植物圧搾汁(Schoenenberger社)の4バッチは、平均4.7±0.4gのセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を与えた。
フリーズドライしたセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物は、平均でわずか6.6±1.0%の水、9.6±1.3%のモノカフェオイルキナ酸の総和、4.5±1.0%のジカフェオイルキナ酸の総和および0.3±0.1%のルチンを含む。
噴霧乾燥によるセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の製造
1lのセイヨウノコギリソウフレッシュ植物圧搾汁(Schoenenberger社、乾燥物含有量5.3%)を150gのマルトデキストリンDE17~20と混合して噴霧乾燥する。得られるのは、75%マルトデキストリンおよび25%乾燥セイヨウノコギリソウフレッシュ植物圧搾汁からなるベージュ色の自由流動性の粉末である。噴霧乾燥濃縮物をモノ-およびジカフェオイルキナ酸の総和およびルチンについて分析する:
皮膚細胞における熱ショックタンパク質の遺伝子発現に対するセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の効果
新生児ヒト表皮ケラチノサイト(nHEK)を6ウェルのマイクロタイタープレートに、0.2×106細胞/キャビティの密度で播種し、EpiLife培地で培養する。24時間のインキュベーション期間後に、例1で得られたセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を0.005質量%の濃度で、EpiLifeに加え、24時間インキュベーションする。
次実行する。
ΔCT値標的遺伝子=CT値標的遺伝子-CT値リファレンス遺伝子(HTRP遺伝子)
標準化後に、処置試料(PS適用)のΔCT値から対照試料(非処置)のΔCT値を減算する。
ΔΔCT値標的遺伝子=ΔCT値処置-ΔCT値対照
最終ステップにおいて、刺激された試料(PS適用)と対照との間の相対発現差(相対定量値(RQ値))を算出する。相対遺伝子発現(RQ値)=2-ΔΔCT
>2.5のRQ値は、遺伝子の相対誘導とみなされる。
皮膚細胞におけるAMPの遺伝子発現に対するセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の効果
HaCaT細胞を、6ウェルのマイクロタイタープレートに、0.5×106細胞/ウェルの密度で播種し、EpiLife培地で培養する。
2日間のインキュベーション期間後に、例1で得られたセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を0.005質量%の濃度で、EpiLifeに加え、24時間インキュベーションする。
mRNAの単離および精製は、Qiagen社のRNeasy(登録商標)Mini Kitを用いて行う。カラムからのmRNAの溶出は、50μlのRNaseフリー水を用いて行う。単離されたRNAの定量および純度決定は、分光光度法によって行う。純度は、吸光度比E260/E280およびE260/E230によって評価する。
RNAのcDNAへの転写は、製造者の指示(RNA-to-cDNA Kit、Applied Biosystems)に従って行う。転写される量は、6ウェルあたり0.5~1μgである。転写された試料は直ちに、PCRで処理するかまたは-20℃で、実験が継続されるまで保存する。
ΔCT値標的遺伝子=CT値標的遺伝子-CT値リファレンス遺伝子(HTRP遺伝子)
標準化後に、処置試料(PS適用)のΔCT値から対照試料(非処置)のΔCT値を減算する。
ΔΔCT値標的遺伝子=ΔCT値処置-ΔCT値対照
最終ステップにおいて、刺激された試料(PS適用)と対照との間の相対発現差(相対定量値(RQ値))を算出する。
相対遺伝子発現(RQ値)=2-ΔΔCT
>2.5のRQ値は、遺伝子の相対誘導とみなされる。
結果は、セイヨウノコギリソウフレッシュ植物圧搾汁が、非常に低い試験濃度において、抗菌ペプチドβ-デフェンシン1およびS100カルシウム結合タンパク質A8の遺伝子発現を非常に効果的に上方制御することを示す。
処方例
1=皮膚用鎮静バーム
2=着色抗老化バーム、SPF15
3=アフターサン保湿スプレーO/W
4=ナイトクリームW/O
5=フェイシャルクレンジングゲル
6=アフターシェイブハイドロゲル
7=抗フケヘアシャンプー
8=制汗ポンプスプレー
9=スキンライトニング用デイケアフルイドO/W
10=バリア機能回復クリームO/W
11=サンプロテクションローションSPF24(UVA/UVBバランス)
処方例1~11において、以下に記載の2種の香油PFO1およびPFO2が、それぞれ、香料として使用される(DPG=ジプロピレングリコール)。
Claims (13)
- 1種以上のジカフェオイルキナ酸を含むセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物の全質量に基づいて、
10~100質量%のセイヨウノコギリソウフレッシュ植物圧搾汁乾燥残渣、
0~10質量%の水、および
0~90質量%の担体
を含むかまたはからなる、皮膚及び/又は毛髪に局所適用するための、凍結乾燥物又は噴霧乾燥物である、セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。 - 前記ジカフェオイルキナ酸又は1種以上の又は全てのジカフェオイルキナ酸が、1,5-ジカフェオイルキナ酸、3,4-ジカフェオイルキナ酸、3,5-ジカフェオイルキナ酸及び4,5-ジカフェオイルキナ酸からなる群から選択される、請求項1に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- 担体が、マルトデキストリン、デキストリンおよびシクロデキストリンからなる群から選択される固体担体、および/または、グリセロール、プロピレングリコール、ブチレングリコール、1,3-プロパンジオール、1,2-ペンタンジオール、1,2-ヘキサンジオールおよび1,2-オクタンジオールからなる群から選択される液体担体である、請求項1または2に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物がさらに、保存剤および/または安定化剤を含む、請求項1から3までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- 噴霧乾燥物である、請求項1から4までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- セイヨウノコギリソウフレッシュ植物圧搾汁を準備するステップ、および
セイヨウノコギリソウフレッシュ植物圧搾汁を噴霧乾燥するステップ、
のステップを含むかまたはステップからなる、請求項1から5までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を製造する方法。 - 請求項1から5までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を含む、皮膚及び/又は毛髪に局所適用するための化粧用組成物。
- 請求項1から5までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を含む、皮膚及び/又は毛髪に局所適用するための医薬組成物。
- 0.01~10質量%の皮膚鎮静剤および/または抗酸化剤をさらに含む、請求項7に記載の化粧用組成物。
- 0.01~10質量%の皮膚鎮静剤および/または抗酸化剤をさらに含む、請求項8に記載の医薬組成物。
- 皮膚細胞における熱ショックタンパク質(HSP)および/または抗菌ペプチド(AMP)の発現を刺激するための、請求項1から5までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- 皮膚の熱耐性を増大するための、請求項1から5までのいずれか1項に記載のセイヨウノコギリソウフレッシュ植物圧搾汁濃縮物。
- セイヨウノコギリソウフレッシュ植物圧搾汁濃縮物を、化粧用組成物の全質量に基づいて0.0001~10質量%の範囲で含む、請求項7または9に記載の化粧用組成物。
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CN116887866A (zh) | 2020-12-03 | 2023-10-13 | 巴特尔纪念研究院 | 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法 |
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EP3615147A1 (de) | 2020-03-04 |
JP2022118016A (ja) | 2022-08-12 |
US11219593B2 (en) | 2022-01-11 |
KR20200002947A (ko) | 2020-01-08 |
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