JP7360716B2 - 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 - Google Patents

核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 Download PDF

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JP7360716B2
JP7360716B2 JP2020529419A JP2020529419A JP7360716B2 JP 7360716 B2 JP7360716 B2 JP 7360716B2 JP 2020529419 A JP2020529419 A JP 2020529419A JP 2020529419 A JP2020529419 A JP 2020529419A JP 7360716 B2 JP7360716 B2 JP 7360716B2
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nucleotide
nucleotide sequence
sirna
seq
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JP2021503930A (ja
JP2021503930A5 (zh
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チャン、ホンイェン
カオ、シャン
カン、タイウー
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Suzhou Ribo Life Science Co Ltd
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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JP2020529419A 2017-12-01 2018-11-29 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 Active JP7360716B2 (ja)

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JP2023160064A JP2023179555A (ja) 2017-12-01 2023-09-25 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用

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CN201711249333 2017-12-01
CN201711249333.8 2017-12-01
CN201711482970 2017-12-29
CN201711482970.X 2017-12-29
PCT/CN2018/118303 WO2019105437A1 (zh) 2017-12-01 2018-11-29 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途

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JP2021503930A JP2021503930A (ja) 2021-02-15
JP2021503930A5 JP2021503930A5 (zh) 2022-01-06
JP7360716B2 true JP7360716B2 (ja) 2023-10-13

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JP2023160064A Pending JP2023179555A (ja) 2017-12-01 2023-09-25 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用

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US (1) US12083142B2 (zh)
EP (1) EP3719125A4 (zh)
JP (2) JP7360716B2 (zh)
KR (1) KR20200095483A (zh)
CN (2) CN110945132B (zh)
AU (1) AU2018377716A1 (zh)
CA (1) CA3083970A1 (zh)
TW (2) TW202409279A (zh)
WO (1) WO2019105437A1 (zh)

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WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
JP7360716B2 (ja) 2017-12-01 2023-10-13 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
US11414665B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
CN118291456A (zh) 2017-12-01 2024-07-05 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
AU2018394875B2 (en) 2017-12-29 2023-08-03 Suzhou Ribo Life Science Co., Ltd. Conjugates and preparation and use thereof
EP3842534A4 (en) 2018-08-21 2022-07-06 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID AND METHOD OF USE THEREOF
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
US20220186221A1 (en) * 2019-05-24 2022-06-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition and conjugate, preparation method and use
CN114685277A (zh) * 2020-12-31 2022-07-01 苏州瑞博生物技术股份有限公司 化合物及羟基丙酸盐类化合物的纯化方法
JP2024528634A (ja) * 2021-07-16 2024-07-30 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物及び複合体並びに調製方法と使用
CA3242059A1 (en) 2021-12-21 2023-06-29 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method thereof and use thereof
WO2023116764A1 (zh) * 2021-12-23 2023-06-29 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及其用途
CN118475374A (zh) * 2022-04-14 2024-08-09 苏州瑞博生物技术股份有限公司 适配体、缀合物与组合物及制备方法和用途
WO2024023262A2 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
WO2024175113A1 (zh) * 2023-02-24 2024-08-29 南京明德新药研发有限公司 包含R和E的双链siRNA类似物及其缀合物

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CA3083970A1 (en) 2019-06-06
TW201928057A (zh) 2019-07-16
CN118236391A (zh) 2024-06-25
CN110945132A (zh) 2020-03-31

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