JP7325186B2 - 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体 - Google Patents

抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体 Download PDF

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JP7325186B2
JP7325186B2 JP2018529991A JP2018529991A JP7325186B2 JP 7325186 B2 JP7325186 B2 JP 7325186B2 JP 2018529991 A JP2018529991 A JP 2018529991A JP 2018529991 A JP2018529991 A JP 2018529991A JP 7325186 B2 JP7325186 B2 JP 7325186B2
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therapeutic agent
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JP2019502676A (ja
JP2019502676A5 (https=
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マリーナ バカック，
シュテファン エヴェルス，
クリスティアン クライン，
パヴェル ピサ，
エーファ ロスマン，
ホセ サーロ，
パブロ ウマーニャ，
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エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト
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Priority claimed from EP15198715.3A external-priority patent/EP3178848A1/en
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/2013—IL-2
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag

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JP2018529991A 2015-12-09 2016-12-06 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体 Active JP7325186B2 (ja)

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JP2021094847A JP7701197B2 (ja) 2015-12-09 2021-06-07 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2023066320A JP2023099017A (ja) 2015-12-09 2023-04-14 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2025097573A JP2025148343A (ja) 2015-12-09 2025-06-11 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP15198715.3 2015-12-09
EP15198715.3A EP3178848A1 (en) 2015-12-09 2015-12-09 Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
EP16172739.1 2016-06-02
EP16172739 2016-06-02
EP16193151.4 2016-10-10
EP16193151 2016-10-10
PCT/EP2016/079800 WO2017097723A2 (en) 2015-12-09 2016-12-06 Treatment method

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JP2021094847A Division JP7701197B2 (ja) 2015-12-09 2021-06-07 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2023066320A Division JP2023099017A (ja) 2015-12-09 2023-04-14 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体

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JP2019502676A JP2019502676A (ja) 2019-01-31
JP2019502676A5 JP2019502676A5 (https=) 2020-01-23
JP7325186B2 true JP7325186B2 (ja) 2023-08-14

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JP2018529991A Active JP7325186B2 (ja) 2015-12-09 2016-12-06 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2021094847A Active JP7701197B2 (ja) 2015-12-09 2021-06-07 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2023066320A Withdrawn JP2023099017A (ja) 2015-12-09 2023-04-14 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2025097573A Pending JP2025148343A (ja) 2015-12-09 2025-06-11 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体

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JP2023066320A Withdrawn JP2023099017A (ja) 2015-12-09 2023-04-14 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
JP2025097573A Pending JP2025148343A (ja) 2015-12-09 2025-06-11 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体

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US (6) US11013801B2 (https=)
EP (2) EP4026848A1 (https=)
JP (4) JP7325186B2 (https=)
KR (1) KR102850929B1 (https=)
CN (2) CN115920030A (https=)
AU (2) AU2016368469B2 (https=)
BR (1) BR112018003984A2 (https=)
CA (1) CA2997406C (https=)
ES (1) ES2901794T3 (https=)
IL (2) IL257696B2 (https=)
MX (3) MX2018005229A (https=)
PL (1) PL3387015T3 (https=)
WO (1) WO2017097723A2 (https=)

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