JP7311514B2 - インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド - Google Patents

インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド Download PDF

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JP7311514B2
JP7311514B2 JP2020533876A JP2020533876A JP7311514B2 JP 7311514 B2 JP7311514 B2 JP 7311514B2 JP 2020533876 A JP2020533876 A JP 2020533876A JP 2020533876 A JP2020533876 A JP 2020533876A JP 7311514 B2 JP7311514 B2 JP 7311514B2
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JP2020532585A5 (enExample
JP2020532585A (ja
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リー，アンロン
チェン，シャオキ
ソン，ヤンタオ
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ベイジン シュエンイー ファーマサイエンシズ カンパニー， リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
JP2020533876A 2017-08-30 2018-08-30 インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド Active JP7311514B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762552148P 2017-08-30 2017-08-30
US62/552,148 2017-08-30
US201862660565P 2018-04-20 2018-04-20
US62/660,565 2018-04-20
PCT/IB2018/056658 WO2019043634A2 (en) 2017-08-30 2018-08-30 CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS

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JP2020532585A JP2020532585A (ja) 2020-11-12
JP2020532585A5 JP2020532585A5 (enExample) 2021-10-07
JP7311514B2 true JP7311514B2 (ja) 2023-07-19

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US (1) US11773132B2 (enExample)
EP (1) EP3692048A4 (enExample)
JP (1) JP7311514B2 (enExample)
KR (1) KR102782200B1 (enExample)
CN (1) CN111263767B (enExample)
AU (1) AU2018323053A1 (enExample)
BR (1) BR112020004047A2 (enExample)
CA (1) CA3073919A1 (enExample)
IL (1) IL272928A (enExample)
MX (1) MX2020002303A (enExample)
RU (1) RU2020112502A (enExample)
SG (1) SG11202001847WA (enExample)
TW (1) TWI808092B (enExample)
WO (1) WO2019043634A2 (enExample)

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IL280430B2 (en) 2016-03-18 2023-11-01 Univ Texas Cyclic dinucleotide compounds and methods of use
WO2018100558A2 (en) 2016-12-01 2018-06-07 Takeda Pharmaceutical Company Limited Cyclic dinucleotide
CA3053568A1 (en) 2017-02-21 2018-08-30 Board Of Regents, The University Of Texas System Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
TWI808092B (zh) 2017-08-30 2023-07-11 中國大陸商北京軒義醫藥科技有限公司 作為干擾素基因調節劑之刺激劑的環狀二核苷酸
PH12020550585A1 (en) 2017-11-10 2021-04-19 Takeda Pharmaceuticals Co Sting modulator compounds, and methods of making and using
JP7250808B2 (ja) * 2018-03-08 2023-04-03 ブリストル－マイヤーズ スクイブ カンパニー 抗がん剤としての環状ジヌクレオチド
US12251394B2 (en) 2018-06-01 2025-03-18 Eisai R&D Management Co., Ltd. Methods for the treatment of bladder cancer
EP3868773A4 (en) * 2018-10-12 2022-07-13 Shanghai Jemincare Pharmaceuticals Co., Ltd. CYCLIC DINUCLEOTIDE COMPOUND AND ITS APPLICATIONS
US12435104B2 (en) * 2019-07-25 2025-10-07 Beigene, Ltd. Cyclic dinucleotides as sting agonists
EP4114417A4 (en) * 2020-03-06 2024-08-14 OD Therapeutics Limited THERAPEUTIC AGENTS AND THEIR CONJUGATES
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
CN111592570B (zh) * 2020-05-15 2022-04-29 清华大学 新型sting激动剂及其制备方法和应用
JP7875196B2 (ja) * 2020-10-20 2026-06-17 タイリガンド バイオサイエンス（シャンハイ）リミテッド 多機能環状ジヌクレオチド及びその使用
KR102466750B1 (ko) * 2020-10-23 2022-11-15 아주대학교산학협력단 인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물
JP7397996B2 (ja) 2020-11-09 2023-12-13 武田薬品工業株式会社 抗体薬物コンジュゲート

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KR20200058411A (ko) 2020-05-27
EP3692048A4 (en) 2021-10-20
SG11202001847WA (en) 2020-03-30
MX2020002303A (es) 2020-09-10
US20200331957A1 (en) 2020-10-22
RU2020112502A3 (enExample) 2021-10-08
WO2019043634A3 (en) 2019-04-11
CN111263767B (zh) 2023-07-18
BR112020004047A2 (pt) 2020-09-01
WO2019043634A2 (en) 2019-03-07
US11773132B2 (en) 2023-10-03
EP3692048A2 (en) 2020-08-12
IL272928A (en) 2020-04-30
TWI808092B (zh) 2023-07-11
TW201919650A (zh) 2019-06-01
CN111263767A (zh) 2020-06-09
RU2020112502A (ru) 2021-10-01
CA3073919A1 (en) 2019-03-07
JP2020532585A (ja) 2020-11-12
AU2018323053A1 (en) 2020-03-19
KR102782200B1 (ko) 2025-03-17

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