JP7311514B2 - インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド - Google Patents
インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド Download PDFInfo
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- JP7311514B2 JP7311514B2 JP2020533876A JP2020533876A JP7311514B2 JP 7311514 B2 JP7311514 B2 JP 7311514B2 JP 2020533876 A JP2020533876 A JP 2020533876A JP 2020533876 A JP2020533876 A JP 2020533876A JP 7311514 B2 JP7311514 B2 JP 7311514B2
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- 125000004122 cyclic group Chemical group 0.000 title description 57
- 108010050904 Interferons Proteins 0.000 title description 3
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- 125000000217 alkyl group Chemical group 0.000 claims description 254
- 150000003839 salts Chemical class 0.000 claims description 186
- 239000012453 solvate Substances 0.000 claims description 155
- 229910052739 hydrogen Inorganic materials 0.000 claims description 146
- 125000000623 heterocyclic group Chemical group 0.000 claims description 105
- 125000003118 aryl group Chemical group 0.000 claims description 90
- 229910052760 oxygen Inorganic materials 0.000 claims description 76
- 229910052736 halogen Inorganic materials 0.000 claims description 65
- 150000002367 halogens Chemical class 0.000 claims description 65
- 229910052717 sulfur Inorganic materials 0.000 claims description 65
- 229910052799 carbon Inorganic materials 0.000 claims description 52
- 229910052731 fluorine Inorganic materials 0.000 claims description 49
- 239000001257 hydrogen Substances 0.000 claims description 48
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 43
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- 125000003545 alkoxy group Chemical group 0.000 description 67
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 19
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- 150000004677 hydrates Chemical class 0.000 description 15
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
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- 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 14
- MCQRPQCQMGVWIQ-UHFFFAOYSA-N boron;methylsulfanylmethane Chemical compound [B].CSC MCQRPQCQMGVWIQ-UHFFFAOYSA-N 0.000 description 14
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
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- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 11
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- 2018-08-30 WO PCT/IB2018/056658 patent/WO2019043634A2/en not_active Ceased
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| SG11202001847WA (en) | 2020-03-30 |
| TW201919650A (zh) | 2019-06-01 |
| RU2020112502A3 (enExample) | 2021-10-08 |
| US20200331957A1 (en) | 2020-10-22 |
| MX2020002303A (es) | 2020-09-10 |
| RU2020112502A (ru) | 2021-10-01 |
| CA3073919A1 (en) | 2019-03-07 |
| KR102782200B1 (ko) | 2025-03-17 |
| AU2018323053A1 (en) | 2020-03-19 |
| IL272928A (en) | 2020-04-30 |
| EP3692048A4 (en) | 2021-10-20 |
| BR112020004047A2 (pt) | 2020-09-01 |
| KR20200058411A (ko) | 2020-05-27 |
| TWI808092B (zh) | 2023-07-11 |
| JP2020532585A (ja) | 2020-11-12 |
| CN111263767B (zh) | 2023-07-18 |
| WO2019043634A2 (en) | 2019-03-07 |
| EP3692048A2 (en) | 2020-08-12 |
| CN111263767A (zh) | 2020-06-09 |
| WO2019043634A3 (en) | 2019-04-11 |
| US11773132B2 (en) | 2023-10-03 |
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