CA3073919A1 - Cyclic di-nucleotides as stimulator of interferon genes modulators - Google Patents
Cyclic di-nucleotides as stimulator of interferon genes modulators Download PDFInfo
- Publication number
- CA3073919A1 CA3073919A1 CA3073919A CA3073919A CA3073919A1 CA 3073919 A1 CA3073919 A1 CA 3073919A1 CA 3073919 A CA3073919 A CA 3073919A CA 3073919 A CA3073919 A CA 3073919A CA 3073919 A1 CA3073919 A1 CA 3073919A1
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- Prior art keywords
- alkyl
- compound
- independently
- cycloalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004122 cyclic group Chemical group 0.000 title description 56
- 101000643024 Homo sapiens Stimulator of interferon genes protein Proteins 0.000 title description 38
- 102100035533 Stimulator of interferon genes protein Human genes 0.000 title description 37
- 239000002773 nucleotide Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 570
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- -1 thiono Chemical group 0.000 claims description 211
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 207
- 229910052739 hydrogen Inorganic materials 0.000 claims description 139
- 125000003118 aryl group Chemical group 0.000 claims description 110
- 125000000623 heterocyclic group Chemical group 0.000 claims description 92
- 125000001424 substituent group Chemical group 0.000 claims description 92
- 229910052736 halogen Inorganic materials 0.000 claims description 83
- 150000002367 halogens Chemical class 0.000 claims description 80
- 238000000034 method Methods 0.000 claims description 72
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 63
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
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- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552148P | 2017-08-30 | 2017-08-30 | |
| US62/552,148 | 2017-08-30 | ||
| US201862660565P | 2018-04-20 | 2018-04-20 | |
| US62/660,565 | 2018-04-20 | ||
| PCT/IB2018/056658 WO2019043634A2 (en) | 2017-08-30 | 2018-08-30 | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3073919A1 true CA3073919A1 (en) | 2019-03-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3073919A Abandoned CA3073919A1 (en) | 2017-08-30 | 2018-08-30 | Cyclic di-nucleotides as stimulator of interferon genes modulators |
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| Country | Link |
|---|---|
| US (1) | US11773132B2 (enExample) |
| EP (1) | EP3692048A4 (enExample) |
| JP (1) | JP7311514B2 (enExample) |
| KR (1) | KR102782200B1 (enExample) |
| CN (1) | CN111263767B (enExample) |
| AU (1) | AU2018323053A1 (enExample) |
| BR (1) | BR112020004047A2 (enExample) |
| CA (1) | CA3073919A1 (enExample) |
| IL (1) | IL272928A (enExample) |
| MX (1) | MX2020002303A (enExample) |
| RU (1) | RU2020112502A (enExample) |
| SG (1) | SG11202001847WA (enExample) |
| TW (1) | TWI808092B (enExample) |
| WO (1) | WO2019043634A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
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| US11773132B2 (en) | 2023-10-03 |
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| EP3692048A4 (en) | 2021-10-20 |
| TW201919650A (zh) | 2019-06-01 |
| KR102782200B1 (ko) | 2025-03-17 |
| SG11202001847WA (en) | 2020-03-30 |
| KR20200058411A (ko) | 2020-05-27 |
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