IL272928A - Cyclic dinucleotides as inducers of interferon gene modulators - Google Patents
Cyclic dinucleotides as inducers of interferon gene modulatorsInfo
- Publication number
- IL272928A IL272928A IL272928A IL27292820A IL272928A IL 272928 A IL272928 A IL 272928A IL 272928 A IL272928 A IL 272928A IL 27292820 A IL27292820 A IL 27292820A IL 272928 A IL272928 A IL 272928A
- Authority
- IL
- Israel
- Prior art keywords
- stimulator
- modulators
- nucleotides
- cyclic
- interferon genes
- Prior art date
Links
- 101000643024 Homo sapiens Stimulator of interferon genes protein Proteins 0.000 title 1
- 102100035533 Stimulator of interferon genes protein Human genes 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552148P | 2017-08-30 | 2017-08-30 | |
| US201862660565P | 2018-04-20 | 2018-04-20 | |
| PCT/IB2018/056658 WO2019043634A2 (en) | 2017-08-30 | 2018-08-30 | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL272928A true IL272928A (en) | 2020-04-30 |
Family
ID=65527221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL272928A IL272928A (en) | 2017-08-30 | 2020-02-26 | Cyclic dinucleotides as inducers of interferon gene modulators |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11773132B2 (enExample) |
| EP (1) | EP3692048A4 (enExample) |
| JP (1) | JP7311514B2 (enExample) |
| KR (1) | KR102782200B1 (enExample) |
| CN (1) | CN111263767B (enExample) |
| AU (1) | AU2018323053A1 (enExample) |
| BR (1) | BR112020004047A2 (enExample) |
| CA (1) | CA3073919A1 (enExample) |
| IL (1) | IL272928A (enExample) |
| MX (1) | MX2020002303A (enExample) |
| RU (1) | RU2020112502A (enExample) |
| SG (1) | SG11202001847WA (enExample) |
| TW (1) | TWI808092B (enExample) |
| WO (1) | WO2019043634A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114751950B (zh) | 2016-03-18 | 2025-04-18 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| PT3512861T (pt) | 2016-12-01 | 2021-04-29 | Takeda Pharmaceuticals Co | Dinucleotídeos cíclicos |
| JP7591348B2 (ja) | 2017-02-21 | 2024-11-28 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
| KR102782200B1 (ko) | 2017-08-30 | 2025-03-17 | 에이제이 사이언시즈 (이씽) 코., 엘티디 | 인터페론 유전자 조절인자의 자극제로서의 환식 다이-뉴클레오타이드 |
| MX2020004858A (es) | 2017-11-10 | 2020-10-01 | Takeda Pharmaceuticals Co | Compuestos moduladores de sting y metodos de elaboracion y uso. |
| US11945834B2 (en) * | 2018-03-08 | 2024-04-02 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| MX2020012964A (es) | 2018-06-01 | 2021-02-16 | Eisai R&D Man Co Ltd | Metodos para el tratamiento de cancer de vejiga. |
| JP7492523B2 (ja) * | 2018-10-12 | 2024-05-29 | シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド | 環状ジヌクレオチド化合物及びその使用 |
| US12435104B2 (en) * | 2019-07-25 | 2025-10-07 | Beigene, Ltd. | Cyclic dinucleotides as sting agonists |
| WO2021178818A2 (en) * | 2020-03-06 | 2021-09-10 | Beijing Xuanyi Pharmasciences Co., Ltd. | Therapeutic agents and conjugates thereof |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN111592570B (zh) * | 2020-05-15 | 2022-04-29 | 清华大学 | 新型sting激动剂及其制备方法和应用 |
| WO2022083584A1 (zh) * | 2020-10-20 | 2022-04-28 | 泰励生物科技（上海）有限公司 | 多功能环二核苷酸及其用途 |
| KR102466750B1 (ko) * | 2020-10-23 | 2022-11-15 | 아주대학교산학협력단 | 인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물 |
| MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
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| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
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| ME03586B (me) | 2013-05-18 | 2020-07-20 | Univ California | Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon" |
| EP3060056A4 (en) | 2013-10-21 | 2017-10-18 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
| EP3071229A4 (en) | 2013-11-22 | 2017-05-10 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| WO2015185565A1 (en) | 2014-06-04 | 2015-12-10 | Glaxosmithkline Intellectual Property Development Limited | Cyclic di-nucleotides as modulators of sting |
| US20170340658A1 (en) | 2014-12-16 | 2017-11-30 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
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| UY36969A (es) | 2015-10-28 | 2017-05-31 | Novartis Ag | Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon |
| JP6411676B2 (ja) * | 2015-12-03 | 2018-10-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド |
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| HUE073018T2 (hu) | 2016-01-11 | 2026-01-28 | Innate Tumor Immunity Inc | Ciklikus dinukleotidok állapotok kezelésére, amelyek STING-aktivitással kapcsolatosak, mint például rák |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| CN114751950B (zh) | 2016-03-18 | 2025-04-18 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
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| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| WO2018045204A1 (en) | 2016-08-31 | 2018-03-08 | Ifm Therapeutics, Inc | Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity |
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| EP3523314A1 (de) * | 2016-10-07 | 2019-08-14 | Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb GmbH | Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen |
| JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| PT3512861T (pt) | 2016-12-01 | 2021-04-29 | Takeda Pharmaceuticals Co | Dinucleotídeos cíclicos |
| AU2017378783A1 (en) | 2016-12-20 | 2019-07-04 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| WO2018119274A1 (en) * | 2016-12-21 | 2018-06-28 | Fred Hutchinson Cancer Research Center | Scaffolds to treat solid tumor cells and escape variants |
| JP7213188B2 (ja) | 2017-01-27 | 2023-01-26 | ヤンセン バイオテツク，インコーポレーテツド | Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド |
| US11492367B2 (en) | 2017-01-27 | 2022-11-08 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| KR102782200B1 (ko) | 2017-08-30 | 2025-03-17 | 에이제이 사이언시즈 (이씽) 코., 엘티디 | 인터페론 유전자 조절인자의 자극제로서의 환식 다이-뉴클레오타이드 |
| JP7492523B2 (ja) * | 2018-10-12 | 2024-05-29 | シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド | 環状ジヌクレオチド化合物及びその使用 |
-
2018
- 2018-08-30 KR KR1020207008457A patent/KR102782200B1/ko active Active
- 2018-08-30 AU AU2018323053A patent/AU2018323053A1/en not_active Abandoned
- 2018-08-30 CN CN201880056293.1A patent/CN111263767B/zh active Active
- 2018-08-30 US US16/643,127 patent/US11773132B2/en active Active
- 2018-08-30 MX MX2020002303A patent/MX2020002303A/es unknown
- 2018-08-30 BR BR112020004047-9A patent/BR112020004047A2/pt not_active IP Right Cessation
- 2018-08-30 TW TW107130419A patent/TWI808092B/zh active
- 2018-08-30 WO PCT/IB2018/056658 patent/WO2019043634A2/en not_active Ceased
- 2018-08-30 SG SG11202001847WA patent/SG11202001847WA/en unknown
- 2018-08-30 RU RU2020112502A patent/RU2020112502A/ru unknown
- 2018-08-30 EP EP18850228.0A patent/EP3692048A4/en active Pending
- 2018-08-30 JP JP2020533876A patent/JP7311514B2/ja active Active
- 2018-08-30 CA CA3073919A patent/CA3073919A1/en not_active Abandoned
-
2020
- 2020-02-26 IL IL272928A patent/IL272928A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202001847WA (en) | 2020-03-30 |
| TW201919650A (zh) | 2019-06-01 |
| RU2020112502A3 (enExample) | 2021-10-08 |
| US20200331957A1 (en) | 2020-10-22 |
| MX2020002303A (es) | 2020-09-10 |
| RU2020112502A (ru) | 2021-10-01 |
| CA3073919A1 (en) | 2019-03-07 |
| KR102782200B1 (ko) | 2025-03-17 |
| AU2018323053A1 (en) | 2020-03-19 |
| EP3692048A4 (en) | 2021-10-20 |
| BR112020004047A2 (pt) | 2020-09-01 |
| KR20200058411A (ko) | 2020-05-27 |
| TWI808092B (zh) | 2023-07-11 |
| JP2020532585A (ja) | 2020-11-12 |
| CN111263767B (zh) | 2023-07-18 |
| JP7311514B2 (ja) | 2023-07-19 |
| WO2019043634A2 (en) | 2019-03-07 |
| EP3692048A2 (en) | 2020-08-12 |
| CN111263767A (zh) | 2020-06-09 |
| WO2019043634A3 (en) | 2019-04-11 |
| US11773132B2 (en) | 2023-10-03 |
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| EM37964730006S (en) | Set of characters | |
| EM37964730005S (cs) | Soubor znaků | |
| EM37964730002S (da) | Tegnsæt | |
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