JP7304863B2 - Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤 - Google Patents

Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤 Download PDF

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JP7304863B2
JP7304863B2 JP2020535541A JP2020535541A JP7304863B2 JP 7304863 B2 JP7304863 B2 JP 7304863B2 JP 2020535541 A JP2020535541 A JP 2020535541A JP 2020535541 A JP2020535541 A JP 2020535541A JP 7304863 B2 JP7304863 B2 JP 7304863B2
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JP2021508697A (ja
JP2021508697A5 (enExample
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ジョン エル． マグナニ，
ジョン エム． ピーターソン，
アルン ケー． サーカー，
ユスフバーイ ユー． ヴォーラ，
ホン－ウン ヤン，
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グリコミメティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
JP2020535541A 2017-12-29 2018-12-28 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤 Active JP7304863B2 (ja)

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JP2023104912A JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

Applications Claiming Priority (3)

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US201762611620P 2017-12-29 2017-12-29
US62/611,620 2017-12-29
PCT/US2018/067961 WO2019133878A1 (en) 2017-12-29 2018-12-28 Heterobifunctional inhibitors of e-selectin and galectin-3

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JP2021508697A JP2021508697A (ja) 2021-03-11
JP2021508697A5 JP2021508697A5 (enExample) 2022-01-11
JP7304863B2 true JP7304863B2 (ja) 2023-07-07

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JP2023104912A Withdrawn JP2023123696A (ja) 2017-12-29 2023-06-27 Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤

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US (1) US11548908B2 (enExample)
EP (1) EP3732186A1 (enExample)
JP (2) JP7304863B2 (enExample)
KR (1) KR20200104889A (enExample)
CN (1) CN111566117A (enExample)
AU (1) AU2018395417B2 (enExample)
BR (1) BR112020013198A2 (enExample)
CA (1) CA3085356A1 (enExample)
WO (1) WO2019133878A1 (enExample)

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CA3122321A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Galectin-3 inhibiting c-glycosides
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3997247A1 (en) 2019-07-12 2022-05-18 GlycoMimetics, Inc. Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
EP4003364A1 (en) * 2019-07-31 2022-06-01 GlycoMimetics, Inc. Use of highly potent multimeric e-selectin antagonists for treating sickle cell disease
CN114401726A (zh) 2019-07-31 2022-04-26 糖模拟物有限公司 E-选择素拮抗剂对提高重建的骨髓耗损宿主的存活的用途
BR112022003186A2 (pt) * 2019-08-20 2022-05-17 Glycomimetics Inc Processo para preparar intermediário de inibidor de e-selectina
WO2021195465A1 (en) 2020-03-27 2021-09-30 Magnani John L Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
WO2021247396A1 (en) 2020-05-31 2021-12-09 Magnani John L Compounds and methods for reduction of cancer cell burden and protection of normal hematopoiesis
JP2023529485A (ja) 2020-06-14 2023-07-10 グリコミメティクス， インコーポレイテッド Ｅ－セレクチン標的化を介して微小環境媒介耐性を克服するための組成物および方法
IL304997A (en) * 2021-02-18 2023-10-01 Glycomimetics Inc A process for preparing an intermediate for selectin-E inhibitor
CN113229815B (zh) * 2021-05-17 2022-07-08 庞尔亮 一种兽医用牲畜疫病检测装置
WO2023014690A1 (en) 2021-08-03 2023-02-09 Glycomimetics, Inc. Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting

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