JP7214851B2 - 加工高麗人参抽出物を含む筋肉分化促進用組成物 - Google Patents
加工高麗人参抽出物を含む筋肉分化促進用組成物 Download PDFInfo
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Description
また、本発明の目的は、前記筋肉分化促進用組成物を含む、筋肉疾患の予防又は治療用薬学組成物及び改善用健康機能食品を提供することにある。
前記組成物は、筋管細胞(myotube)分化を促進することができる。
前記組成物は、ミオスタチン(myostatin)による筋萎縮現象を抑制することができる。
本発明はまた、前記筋肉分化促進用組成物及び食品学的に許容可能な食品補助添加剤を含む筋肉疾患改善用の健康機能食品に関する。
本発明は、加工高麗人参抽出物を有効成分として含む筋肉分化促進用組成物に関する。
前記微量のジンセノシドは、筋肉分化促進効果があるジンセノシドであり得、好ましくは、ジンセノシドRh2及びRg3である。
前記筋肉分化促進用組成物は、筋芽細胞から筋管細胞への分化を促進することができ、筋管細胞の幅を増加させることができる。
前記筋肉分化促進用組成物は筋管細胞の萎縮を抑制させることができる。
前記筋肉分化促進用組成物は、マイオディーのような筋肉調節因子の発現を増加させることができる。
前記筋肉分化促進用組成物はミオスタチンを抑制させることができる。
また、本発明は、前記筋肉分化促進用組成物を有効成分として含む筋肉疾患の予防又は治療用薬学的組成物に関する。
前記薬学的組成物は、筋肉細胞への分化を促進させることによって筋肉疾患を予防又は治療するために用いることができる。
前記薬学的組成物は、前記筋肉分化促進用組成物及び薬学的に許容可能な担体を含むことができる。
前記健康機能食品は、前記筋肉分化促進用組成物及び食品学的に許容可能な食品補助添加剤を含む筋肉疾患改善用の健康機能食品である。
これによって、本発明の加工高麗人参抽出物を用いて、優れた効果を有する筋肉疾患の予防又は治療用組成物が開発できると期待される。
<比較例1.高麗人参粉末の製造>
6年根高麗人参200gを熱風乾燥後に粉砕し、60gの高麗人参粉末を得た。
<比較例2.高麗人参濃縮液の製造>
6年根高麗人参200gを熱風乾燥させた後、1Lの70%酒精を添加して70℃で8時間撹拌後に抽出、濾過、及び濃縮し、50gの高麗人参濃縮液を得た。
<比較例3.高麗人参濃縮液粉末の製造>
6年根高麗人参200gを熱風乾燥させた後、1Lの70%酒精を添加して70℃で8時間撹拌後に抽出、濾過、濃縮、及び乾燥させ、30gの高麗人参濃縮液粉末を得た。
6年根高麗人参200gを98℃で1時間蒸気で蒸して乾燥後に粉砕し、40gの紅参粉末を得た。
<比較例5.紅参濃縮液の製造>
6年根高麗人参200gを98℃で1時間蒸気で蒸して乾燥させた後、1Lの70%酒精を添加して70℃で8時間撹拌後に抽出、濾過、及び濃縮し、30gの紅参濃縮液を得た。
<比較例6.紅参濃縮液粉末の製造>
6年根高麗人参200gを98℃で1時間蒸気で蒸して乾燥させた後、1Lの70%酒精を添加して70℃で8時間撹拌後に抽出、濾過、濃縮、及び乾燥させ、25gの紅参濃縮液粉末を得た。
比較例1の高麗人参粉末99.5gにジンセノシドRh2 0.2gとRg3 0.3gを混合した。
<比較例8.紅参粉末+Rh2 0.3%+Rg3 0.3%の製造>
比較例4の紅参粉末99.5gにジンセノシドRh2 0.2gとRg3 0.3gを混合した。
<比較例9.紅参粉末+Rh21%の製造>
比較例4の紅参粉末99gにジンセノシドRh2 1gを混合した。
<比較例10.紅参粉末+Rg3 1%の製造>
比較例4の紅参粉末99gにジンセノシドRg3 1gを混合した。
<比較例11.紅参粉末+Rh2 0.5%+Rg3 0.5%の製造>
比較例4の紅参粉末99gにジンセノシドRh2 0.5gとRg3 0.5gを混合した。
高麗人参粉末250g、フスマ750gを入れて121℃、1.5気圧下で高圧蒸気滅菌機で滅菌した。滅菌された培地に滅菌水2Lを入れて混合した後、アスペルギルスニガー(Aspergillus niger)懸濁液(5×105胞子/培地重さg)を28℃で7日間培養した。培養完了後、0.02M酢酸ナトリウム緩衝溶液を添加して混合した後、培地を濾過した。濾過した培養液を限外濾過膜(100kDa以上)を用いて濾過及び濃縮し、酵素液60gを得た。比較例1の高麗人参粉末200gに酵素液30gを添加して28℃で18時間培養した後、酒精を添加して酵素を沈殿、上澄液を濃縮した。前記濃縮物200gに2Lの精製水を加えた後にクエン酸250gを添加し、50℃で18時間撹拌した。反応が完了すると、70%酒精を添加して濾過、濃縮し、200gの加工高麗人参粉末を得た。
<実施例2.高麗人参濃縮液を用いた加工高麗人参濃縮液の製造>
<実施例3.高麗人参濃縮液粉末を用いた加工高麗人参濃縮液粉末の製造>
<実施例4.紅参粉末を用いた加工紅参粉末の製造>
<実施例5.紅参濃縮液を用いた加工紅参濃縮液の製造>
<実施例6.紅参濃縮液粉末を用いた加工紅参濃縮液粉末の製造>
筋肉分化過程で筋芽細胞の分裂が起き、筋芽細胞同士の融合が起き、筋管細胞に発達して最終的に筋肉を形成する。したがって、本発明の加工高麗人参抽出物の筋肉分化への影響を確認するために筋管細胞への分化活性を確認した。
図1に見られるように、(A)の分化前と違い、(B)の分化を誘導した後には複数の筋芽細胞が融合して管状の筋管細胞を形成することを確認した。
このことから、C2C12細胞にウマ血清を処理することによって筋肉分化を誘導できることが分かった。
本発明の加工高麗人参抽出物の細胞毒性の有無を確認するために、前記実験例1で分化させた筋管細胞を用いた。
このような結果は、他の実施例の加工高麗人参抽出物を処理した場合にも類似に得られた。
このことから、本発明の加工高麗人参抽出物の最高処理濃度が30μg/mlであることが分かった。
筋肉分化過程で筋芽細胞の分裂が起き、筋芽細胞同士の融合が起き、筋管細胞に発達して最終的に筋肉を形成する。したがって、本発明の加工高麗人参抽出物の筋肉分化への影響を確認するために筋管細胞形成誘導活性を確認した。
このことから、本発明の加工高麗人参抽出物のようにジンセノシドRh2及びRg3を共に投与した場合に筋肉分化促進効果が増加することが分かった。
筋肉分化過程中に生成された筋管細胞は、その長さ及び幅が増加しながら周辺の筋管細胞と融合して筋繊維を形成する。したがって、本発明の加工高麗人参抽出物の筋肉分化への影響を確認するために、筋管細胞の幅の増加効果を確認した。
このことから、本発明の加工高麗人参抽出物が筋管細胞の幅の増加によって筋肉分化を促進する効果があることが分かった。
実験例5-1.筋萎縮動物細胞モデルの製造
本発明の加工高麗人参抽出物の筋萎縮抑制効果を確認するために、筋萎縮動物細胞モデルを製造した。この時、筋萎縮が起きると筋管細胞の幅及び長さが減少することに基づいて動物細胞モデルを製造した。
本発明の加工高麗人参抽出物の筋萎縮抑制効果を確認するために、前記実験例5-1の筋萎縮動物細胞モデルの製造方法と同じ方法で筋萎縮を誘導した後、筋管細胞の幅の変化を観察し、その結果を図6に示した。この時、ミオスタチン(MSTN)0.4μg/mlと前記実施例2の加工高麗人参抽出物30μg/mlを24時間単独処理又は併用処理し、ミオスタチン及び実施例2の加工高麗人参抽出物を処理していない筋管細胞を対照群として用いた。
実験例6-1.Smad2リン酸化抑制効果確認
ミオスタチン(MSTN)は、アクチビンタイプII受容体(activin type II receptor,ActRIIB)-Smad2信号伝達経路の活性化を通じてユビキチンプロテアソーム経路(ubiquitin proteasome pathway,UPP)媒介タンパク質分解を増加させ、筋萎縮を誘導するものと知られている。そこで、本発明の加工高麗人参抽出物の、ミオスタチンによる筋萎縮抑制効果を確認するために、ActRIIB-Smad2信号伝達経路のうちSmad2のリン酸化抑制の有無を確認した。
筋肉分化に重要な筋原繊維タンパク質発現に中核的な転写因子であるマイオディー(MyoD)の分解過程は、ミオスタチン(MSTN)-ActRIIB-Smad2経路によって活性化されるUPP過程によって主に導かれることが知られている。UPP過程は、対象タンパク質に特化したユビキチン化E3リガーゼ(ligase)によって調節されるが、この過程に中核的なマイオディーのE3リガーゼはMAFbxと知られている。そこで、本発明の加工高麗人参抽出物の、ミオスタチンによる筋萎縮抑制効果を確認するために、マイオディーとMAFbxの含有量変化を確認した。
Claims (4)
- 加工高麗人参抽出物を有効成分として含む筋肉分化促進用組成物であって、
前記加工高麗人参抽出物は、ジンセノシドRh2及びRg3をそれぞれ0.5~30重量%含有する
ことを特徴とする筋肉分化促進用組成物。 - 前記組成物は、筋管細胞(myotube)分化を促進する
請求項1に記載の筋肉分化促進用組成物。 - 前記組成物は、ミオスタチン(myostatin)による筋萎縮現象を抑制する
請求項1に記載の筋肉分化促進用組成物。 - 前記ミオスタチン(myostatin)による筋萎縮現象が、
筋萎縮症(muscular atrophy)、筋疾患(myopathy)、筋肉損傷(muscular injury)、筋異栄養症(muscular dystrophy)、筋無力症(myasthenia)、筋萎縮性側索硬化症(amyotrophic lateral sclerosis,ALS)、悪液質(cachexia)及び退行性筋肉疾患(degenerative muscle diseases)からなる群から選ばれるいずれかである
請求項3に記載の筋肉分化促進用組成物。
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- 2019-05-24 WO PCT/KR2019/006265 patent/WO2019226015A1/ko unknown
- 2019-05-24 JP JP2021516346A patent/JP7214851B2/ja active Active
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KR101595426B1 (ko) | 2013-08-30 | 2016-02-18 | (주)녹십자웰빙 | 진세노사이드 성분이 증가된 가공인삼분말 또는 가공인삼추출물을 함유하는 암 관련 피로의 예방 및 치료용 조성물 |
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EP3804738A1 (en) | 2021-04-14 |
US20210205387A1 (en) | 2021-07-08 |
WO2019226015A1 (ko) | 2019-11-28 |
KR101966117B1 (ko) | 2019-04-05 |
EP3804738A4 (en) | 2022-01-26 |
CN112236156A (zh) | 2021-01-15 |
JP2021524506A (ja) | 2021-09-13 |
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