JP7195147B2 - Ｐｅｇ化リポソームおよび使用方法 - Google Patents

Ｐｅｇ化リポソームおよび使用方法 Download PDF

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JP7195147B2
JP7195147B2 JP2018559785A JP2018559785A JP7195147B2 JP 7195147 B2 JP7195147 B2 JP 7195147B2 JP 2018559785 A JP2018559785 A JP 2018559785A JP 2018559785 A JP2018559785 A JP 2018559785A JP 7195147 B2 JP7195147 B2 JP 7195147B2
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pegylated
lipid
liposomes
mol
antigen
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JP2019518739A5 (pt
JP2019518739A (ja
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フォックス，クリストファー，ビー．
リン，スーザン，エス．
カーター，ダリック
ホーベン，ニール ヴァン
アビヤンカー，マユレッシュ，エム．
ペトリ，ウイリアム，エイ．，ジュニア．
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アクセス ツー アドバンスト ヘルス インスティチュート
ユニヴァーシティー オブ ヴァージニア パテント ファンデーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
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    • C12N2760/16171—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Inorganic Chemistry (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018559785A 2016-05-16 2017-05-15 Ｐｅｇ化リポソームおよび使用方法 Active JP7195147B2 (ja)

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JP2022143788A JP2022177112A (ja) 2016-05-16 2022-09-09 Ｐｅｇ化リポソームおよび使用方法

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US201662337328P 2016-05-16 2016-05-16
US62/337,328 2016-05-16
PCT/US2017/032756 WO2017200957A1 (en) 2016-05-16 2017-05-15 Pegylated liposomes and methods of use

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JP2019518739A JP2019518739A (ja) 2019-07-04
JP2019518739A5 JP2019518739A5 (pt) 2020-06-25
JP7195147B2 true JP7195147B2 (ja) 2022-12-23

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JP2022143788A Pending JP2022177112A (ja) 2016-05-16 2022-09-09 Ｐｅｇ化リポソームおよび使用方法

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US (2) US11266602B2 (pt)
EP (1) EP3458028A1 (pt)
JP (2) JP7195147B2 (pt)
KR (1) KR102483033B1 (pt)
CN (1) CN109562057A (pt)
AU (2) AU2017268175B2 (pt)
BR (1) BR112018073676B1 (pt)
CA (1) CA3023672A1 (pt)
IL (2) IL263030B1 (pt)
MX (1) MX2018013640A (pt)
WO (1) WO2017200957A1 (pt)
ZA (1) ZA201807128B (pt)

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CN109562057A (zh) 2016-05-16 2019-04-02 传染病研究所 聚乙二醇化脂质体和使用方法
CN107998070A (zh) * 2017-12-12 2018-05-08 南京中医药大学 一种复合磷脂传递体及其在制备经皮给药制剂中的应用
US20220339282A1 (en) * 2018-11-29 2022-10-27 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
BR112021010717A2 (pt) * 2018-12-17 2021-08-31 Eisai R&D Management Co., Ltd. Formulação que compreende lipossomas
CN110151702A (zh) * 2019-06-24 2019-08-23 昆明医科大学 聚乙二醇修饰流感疫苗脂质体及其制备方法
US11679163B2 (en) 2019-09-20 2023-06-20 Hdt Bio Corp. Compositions and methods for delivery of RNA
KR102328531B1 (ko) * 2020-01-23 2021-11-17 서울대학교산학협력단 체내 면역 세포 표적 황화수소 공여체 담지 리포좀을 포함하는 면역질환 치료 또는 예방용 약학 조성물
AU2021241355A1 (en) 2020-03-23 2022-10-13 Hdt Bio Corp. Compositions and methods for delivery of RNA
US20240050561A1 (en) 2020-12-23 2024-02-15 Access To Advanced Health Institute Solanesol vaccine adjuvants and methods of preparing same
US20240180834A1 (en) * 2021-02-26 2024-06-06 Univesity Of Virginia Patent Foundation Development of covid-19 vaccine using a dual tlr ligand liposome adjuvant
US20240189445A1 (en) * 2021-03-11 2024-06-13 Drew Weissman Targeted Therapeutic Lipid Nanoparticles and Methods of Use
KR102682082B1 (ko) * 2021-06-01 2024-07-05 서울대학교산학협력단 리포좀 및 이를 포함하는 암 방사선 치료용 약학 조성물
WO2024137455A1 (en) * 2022-12-19 2024-06-27 Newimmune Ii, Llc Nanoparticulate formulation
CN115737800B (zh) * 2023-01-09 2023-05-23 江苏瑞科生物技术股份有限公司 一种复合脂质体佐剂及其制备方法

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JP2015512950A (ja) 2012-04-12 2015-04-30 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 異なる医薬品の制御送達のためのビヒクル
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