JP7086928B2 - 改変されたナチュラルキラー細胞を生成する方法および使用方法 - Google Patents
改変されたナチュラルキラー細胞を生成する方法および使用方法 Download PDFInfo
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- JP7086928B2 JP7086928B2 JP2019503538A JP2019503538A JP7086928B2 JP 7086928 B2 JP7086928 B2 JP 7086928B2 JP 2019503538 A JP2019503538 A JP 2019503538A JP 2019503538 A JP2019503538 A JP 2019503538A JP 7086928 B2 JP7086928 B2 JP 7086928B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662366493P | 2016-07-25 | 2016-07-25 | |
| US62/366,493 | 2016-07-25 | ||
| PCT/US2017/043774 WO2018022646A1 (en) | 2016-07-25 | 2017-07-25 | Methods of producing modified natural killer cells and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523001A JP2019523001A (ja) | 2019-08-22 |
| JP2019523001A5 JP2019523001A5 (enExample) | 2020-08-06 |
| JP7086928B2 true JP7086928B2 (ja) | 2022-06-20 |
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ID=59656171
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503538A Active JP7086928B2 (ja) | 2016-07-25 | 2017-07-25 | 改変されたナチュラルキラー細胞を生成する方法および使用方法 |
| JP2020524196A Active JP7364559B2 (ja) | 2016-07-25 | 2018-11-01 | 改変されたナチュラルキラー細胞を生成する方法および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524196A Active JP7364559B2 (ja) | 2016-07-25 | 2018-11-01 | 改変されたナチュラルキラー細胞を生成する方法および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11293010B2 (enExample) |
| EP (2) | EP3487991B1 (enExample) |
| JP (2) | JP7086928B2 (enExample) |
| CN (2) | CN109844099B (enExample) |
| IL (1) | IL273979B2 (enExample) |
| SG (2) | SG11201810871WA (enExample) |
| WO (2) | WO2018022646A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| US10813952B2 (en) * | 2014-11-14 | 2020-10-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | NK cells with an increased antibody-dependent cellular toxicity (ADCC) against tumors |
| EP3487991B1 (en) * | 2016-07-25 | 2022-09-07 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods of producing modified natural killer cells and methods of use |
| WO2018104554A1 (en) * | 2016-12-09 | 2018-06-14 | Onkimmune Limited | Improved nk-based cell therapy |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| BR112020016876A2 (pt) * | 2018-02-21 | 2020-12-15 | Board Of Regents, The University Of Texas System | Células apresentadoras de antígeno universal e usos das mesmas |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| WO2019222503A1 (en) * | 2018-05-16 | 2019-11-21 | Research Institute At Nationwide Children's Hospital | Generation of knock-out primary and expanded human nk cells using cas9 ribonucleoproteins |
| JP2021524467A (ja) | 2018-05-23 | 2021-09-13 | メニスマート セラピューティクス, インコーポレイテッドManysmart Therapeutics, Inc. | 二重特異性t細胞誘導体及びその使用 |
| WO2019229109A1 (en) * | 2018-05-30 | 2019-12-05 | Glycostem Therapeutics B.V. | Car nk cells |
| US20210230542A1 (en) * | 2018-06-06 | 2021-07-29 | Stemcell Technologies Canada Inc. | Kits, compositions and methods for cell enrichment |
| CN119752801A (zh) * | 2018-08-01 | 2025-04-04 | 南克维斯特公司 | 用于免疫疗法的基因修饰的包含归巢受体或细胞因子和嵌合抗原受体的四顺反子系统 |
| CA3110926A1 (en) * | 2018-08-28 | 2020-03-05 | Pharos Vaccine Inc. | Improved lentiviral vector |
| EP3845564A4 (en) * | 2018-08-28 | 2022-05-18 | Immunotech Biopharm Co., Ltd. | ENHANCED THERAPEUTIC T LYMPHOCYTE |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| CN110511912B (zh) * | 2018-08-30 | 2024-03-22 | 浙江煦顼技术有限公司 | 免疫细胞的功能调节 |
| WO2020077091A1 (en) * | 2018-10-10 | 2020-04-16 | Wisconsin Alumni Research Foundation | Kir 7.1 gene therapy vectors and methods of using the same |
| CN109402053A (zh) * | 2018-10-17 | 2019-03-01 | 广州元帅生物科技有限公司 | 一种外周血来源单个核细胞的分离及诱导培养方法 |
| CN113891934A (zh) * | 2018-11-21 | 2022-01-04 | 因达普塔治疗公司 | 扩增天然杀伤(nk)细胞子集的方法以及相关组合物和方法 |
| WO2020172328A1 (en) * | 2019-02-20 | 2020-08-27 | Rutgers, The State University Of New Jersey | Expansion of natural killer and chimeric antigen receptor-modified cells |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| CN113710697A (zh) | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| KR20200110576A (ko) * | 2019-03-15 | 2020-09-24 | 재단법인대구경북과학기술원 | 사이토카인 기반 면역세포 및 그의 면역 치료 용도 |
| EP3712257A1 (en) * | 2019-03-21 | 2020-09-23 | ONK Therapeutics Limited | Modified natural killer cells with increased resistance to cell death |
| BR112021018600B1 (pt) * | 2019-03-21 | 2023-10-17 | Onk Therapeutics Limited | Uso de uma célula nk e seu método de produção |
| CN110079529A (zh) * | 2019-04-28 | 2019-08-02 | 成都美杰赛尔生物科技有限公司 | 用于靶向敲除人NKG2A/KLRC1基因的sgRNA、表达载体、试剂盒及其用途 |
| CN110106202A (zh) * | 2019-05-07 | 2019-08-09 | 杭州师范大学 | 抗肿瘤nk细胞的制备方法及其细胞与应用 |
| JP2022537162A (ja) * | 2019-06-14 | 2022-08-24 | ジー・テック・バイオ・エルエルシー | 活性化リンパ球細胞ならびにそれを使用してがん及び感染状態を治療する方法 |
| CN110205293A (zh) * | 2019-06-25 | 2019-09-06 | 中冠赛尔生物科技(北京)有限公司 | 一种加强型高效治疗肺癌的nk免疫细胞的制备方法及应用 |
| US20220347216A1 (en) * | 2019-09-13 | 2022-11-03 | Ohio State Innovation Foundation | Nk cell immunotherapy compositions, methods of making and methods of using same |
| US20210077527A1 (en) * | 2019-09-13 | 2021-03-18 | The Research Institute At Nationwide Children's Hospital | Universal donor selection method to identify nk-cell-donors |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| WO2021194495A1 (en) | 2020-03-26 | 2021-09-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd28h domain-containing chimeric antigen receptors and methods of use |
| CN113528452B (zh) * | 2020-07-06 | 2023-06-06 | 上海鑫湾生物科技有限公司 | 共表达IL-21和hrCD16嵌合受体的免疫细胞及其应用 |
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| SG11202003201QA (en) | 2020-05-28 |
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