JP7069011B2 - 間葉幹細胞由来のエクソソームおよびその使用 - Google Patents

間葉幹細胞由来のエクソソームおよびその使用 Download PDF

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JP7069011B2
JP7069011B2 JP2018522514A JP2018522514A JP7069011B2 JP 7069011 B2 JP7069011 B2 JP 7069011B2 JP 2018522514 A JP2018522514 A JP 2018522514A JP 2018522514 A JP2018522514 A JP 2018522514A JP 7069011 B2 JP7069011 B2 JP 7069011B2
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exosomes
kda
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molecular weight
tgf
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JP2018531979A5 (https=
JP2018531979A (ja
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オルガ、デ、ラ、ロサ
エルウテーリオ、ロンバルド
ウィルフリート、ダレマン
ハビエル、ガルシア、カサド
レベッカ、ブラスケス、デュラン
フランシスコ、ミゲル、サンチェス、マルガリョ
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Orthopedic Medicine & Surgery (AREA)
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  • Transplantation (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018522514A 2015-11-02 2016-11-02 間葉幹細胞由来のエクソソームおよびその使用 Active JP7069011B2 (ja)

Applications Claiming Priority (3)

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US14/929,578 US20170121685A1 (en) 2015-11-02 2015-11-02 Mesenchymal stem cell-derived exosomes and their uses
US14/929,578 2015-11-02
PCT/EP2016/076462 WO2017076924A1 (en) 2015-11-02 2016-11-02 Mesenchymal stem cell-derived exosomes and their uses

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JP2018531979A JP2018531979A (ja) 2018-11-01
JP2018531979A5 JP2018531979A5 (https=) 2019-12-12
JP7069011B2 true JP7069011B2 (ja) 2022-05-17

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US (1) US20170121685A1 (https=)
EP (1) EP3371298A1 (https=)
JP (1) JP7069011B2 (https=)
CA (1) CA3003603A1 (https=)
HK (1) HK1254948A1 (https=)
IL (1) IL259147B (https=)
WO (1) WO2017076924A1 (https=)

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KR20190011213A (ko) * 2017-07-24 2019-02-01 한양대학교 에리카산학협력단 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물
US11766402B2 (en) 2017-11-16 2023-09-26 Board Of Regents, The University Of Texas System Methods for production of MSC-derived exosomes
WO2019105082A1 (zh) * 2017-11-30 2019-06-06 苏州科睿思制药有限公司 Galunisertib的晶型及其制备方法和用途
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US12257266B2 (en) 2018-03-02 2025-03-25 The Regents Of The University Of California Stem cell-derived exosomes for the treatment of corneal scarring
EP3775258A4 (en) 2018-03-28 2022-01-26 Board of Regents, The University of Texas System IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES
JP2021526556A (ja) 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法
CN108865985A (zh) * 2018-06-22 2018-11-23 山东省职业卫生与职业病防治研究院 一种干细胞源外泌体干预上皮-间质转化的方法
CN109161526A (zh) * 2018-10-12 2019-01-08 希瑞干细胞科技有限公司 一种绒毛膜间充质干细胞复苏培养基
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
EP3927317A4 (en) * 2019-02-19 2022-08-10 Direct Biologics, LLC ACELLULAR INTRAVENOUS INFUSION WITH GROWTH FACTORS FROM MESENCHYMAL STEM CELLS AND EXOSOMES
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KR102132457B1 (ko) * 2019-05-10 2020-07-09 주식회사 바이오솔루션 세포외 소포를 고농도로 배양하기 위한 세포 배양배지 및 상기 세포 배양배지를 이용한 세포외 소포 고 함유 조건화 배양액의 제조방법
CN110184235B (zh) * 2019-05-21 2021-03-02 葛楠 一种adsc外泌体及其制备方法与应用
CN118147051A (zh) * 2019-06-10 2024-06-07 布瑞克斯奥根株式会社 用于促进干细胞来源外泌体产生和增加干性的包含白藜芦醇的组合物
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JP2023537204A (ja) * 2020-07-09 2023-08-31 エクソ バイオロジクス エスアー 間葉系ストローマ細胞由来の細胞外小胞（ｅｖ）および前記ｅｖを得るための方法
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EP3371298A1 (en) 2018-09-12
IL259147B (en) 2022-07-01
HK1254948A1 (zh) 2019-08-02
US20170121685A1 (en) 2017-05-04
WO2017076924A9 (en) 2017-07-27
JP2018531979A (ja) 2018-11-01
WO2017076924A1 (en) 2017-05-11
IL259147A (en) 2018-06-28
CA3003603A1 (en) 2017-05-11

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