JP2018531979A5 - - Google Patents
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- Publication number
- JP2018531979A5 JP2018531979A5 JP2018522514A JP2018522514A JP2018531979A5 JP 2018531979 A5 JP2018531979 A5 JP 2018531979A5 JP 2018522514 A JP2018522514 A JP 2018522514A JP 2018522514 A JP2018522514 A JP 2018522514A JP 2018531979 A5 JP2018531979 A5 JP 2018531979A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- exosomes
- use according
- tgf
- msc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001808 exosome Anatomy 0.000 claims 7
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007919 intrasynovial administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000001331 nose Anatomy 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/929,578 US20170121685A1 (en) | 2015-11-02 | 2015-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
| US14/929,578 | 2015-11-02 | ||
| PCT/EP2016/076462 WO2017076924A1 (en) | 2015-11-02 | 2016-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531979A JP2018531979A (ja) | 2018-11-01 |
| JP2018531979A5 true JP2018531979A5 (https=) | 2019-12-12 |
| JP7069011B2 JP7069011B2 (ja) | 2022-05-17 |
Family
ID=57517849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522514A Active JP7069011B2 (ja) | 2015-11-02 | 2016-11-02 | 間葉幹細胞由来のエクソソームおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170121685A1 (https=) |
| EP (1) | EP3371298A1 (https=) |
| JP (1) | JP7069011B2 (https=) |
| CA (1) | CA3003603A1 (https=) |
| HK (1) | HK1254948A1 (https=) |
| IL (1) | IL259147B (https=) |
| WO (1) | WO2017076924A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9919011B2 (en) * | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| KR20190003316A (ko) * | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| FR3068361B1 (fr) | 2017-06-30 | 2021-10-15 | Univ Paris Diderot Paris 7 | Systeme fluidique de production de vesicules extracellulaires et procede associe |
| KR20190011213A (ko) * | 2017-07-24 | 2019-02-01 | 한양대학교 에리카산학협력단 | 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물 |
| US11766402B2 (en) | 2017-11-16 | 2023-09-26 | Board Of Regents, The University Of Texas System | Methods for production of MSC-derived exosomes |
| WO2019105082A1 (zh) * | 2017-11-30 | 2019-06-06 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| US20210161967A1 (en) * | 2017-12-06 | 2021-06-03 | Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" | Extracellular vesicles and uses thereof |
| US12257266B2 (en) | 2018-03-02 | 2025-03-25 | The Regents Of The University Of California | Stem cell-derived exosomes for the treatment of corneal scarring |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法 |
| CN108865985A (zh) * | 2018-06-22 | 2018-11-23 | 山东省职业卫生与职业病防治研究院 | 一种干细胞源外泌体干预上皮-间质转化的方法 |
| CN109161526A (zh) * | 2018-10-12 | 2019-01-08 | 希瑞干细胞科技有限公司 | 一种绒毛膜间充质干细胞复苏培养基 |
| BR112021015549A2 (pt) | 2019-02-07 | 2021-10-26 | Direct Biologics Llc | Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes |
| EP3927317A4 (en) * | 2019-02-19 | 2022-08-10 | Direct Biologics, LLC | ACELLULAR INTRAVENOUS INFUSION WITH GROWTH FACTORS FROM MESENCHYMAL STEM CELLS AND EXOSOMES |
| US12350293B2 (en) | 2019-03-08 | 2025-07-08 | Niigata University | Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition |
| KR102132457B1 (ko) * | 2019-05-10 | 2020-07-09 | 주식회사 바이오솔루션 | 세포외 소포를 고농도로 배양하기 위한 세포 배양배지 및 상기 세포 배양배지를 이용한 세포외 소포 고 함유 조건화 배양액의 제조방법 |
| CN110184235B (zh) * | 2019-05-21 | 2021-03-02 | 葛楠 | 一种adsc外泌体及其制备方法与应用 |
| CN118147051A (zh) * | 2019-06-10 | 2024-06-07 | 布瑞克斯奥根株式会社 | 用于促进干细胞来源外泌体产生和增加干性的包含白藜芦醇的组合物 |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| CN110946876A (zh) * | 2019-10-28 | 2020-04-03 | 天津市康婷生物工程集团有限公司 | 间充质干细胞外泌体制剂在治疗斑秃中的应用 |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| KR102319735B1 (ko) * | 2020-04-28 | 2021-11-01 | 건국대학교 산학협력단 | 3차원 배양된 줄기세포로부터 세포외 소포체를 제조하는 방법 |
| WO2021251616A1 (ko) * | 2020-06-10 | 2021-12-16 | 재단법인 대구경북첨단의료산업진흥재단 | 고양이과 동물 중간엽 줄기세포 유래 엑소좀을 포함하는 조성물 및 이를 이용한 염증질환 치료방법 |
| JP2023537204A (ja) * | 2020-07-09 | 2023-08-31 | エクソ バイオロジクス エスアー | 間葉系ストローマ細胞由来の細胞外小胞（ｅｖ）および前記ｅｖを得るための方法 |
| CN111849882A (zh) * | 2020-07-17 | 2020-10-30 | 尧舜泽生物医药(南京)有限公司 | 间充质干细胞外泌体及其制备方法和应用 |
| CN111944747A (zh) * | 2020-08-14 | 2020-11-17 | 福建医科大学附属协和医院 | 一种用于治疗心肌梗死的人脂肪间充质干细胞外泌体及其用途 |
| EP4212163A4 (en) | 2020-09-08 | 2024-09-18 | Dexon Pharmaceuticals Inc. | CYTOKINE STORM INHIBITOR, METHOD FOR USING CYTOKINE STORM INHIBITOR, AND METHOD FOR SCREENING CYTOKINE INHIBITOR |
| WO2022080461A1 (ja) * | 2020-10-16 | 2022-04-21 | 富士フイルム和光純薬株式会社 | 細胞外小胞の産生用培地、培地キット、添加剤及び細胞外小胞の産生方法 |
| CN116888126B (zh) * | 2020-12-15 | 2026-03-17 | 北京原基华毅生物科技有限公司 | 一种酪蛋白激酶抑制剂的化合物 |
| CN115029317B (zh) * | 2021-02-23 | 2025-10-28 | 赛浦生物科技(长春)有限公司 | 用于过敏性鼻炎的鼻喷雾剂及制备方法 |
| CN112915105B (zh) * | 2021-03-12 | 2024-07-19 | 上海市第六人民医院 | 间充质干细胞分泌的小细胞外囊泡在制备治疗cp/cpps的药物上的应用 |
| CN112961240B (zh) * | 2021-04-06 | 2022-07-05 | 明济生物制药（北京）有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| CN113174363B (zh) * | 2021-04-21 | 2023-05-30 | 天晴干细胞股份有限公司 | 用于促进iPSC分化为胰岛素分泌细胞的混合物及其制备方法 |
| CN113846047A (zh) * | 2021-06-22 | 2021-12-28 | 姜海涛 | 一种肾靶向载药外泌体及应用和治疗肾脏疾病药物 |
| CN114164172A (zh) * | 2021-08-27 | 2022-03-11 | 广州百暨基因科技有限公司 | 间充质干细胞外泌体的制备方法 |
| CN113930393A (zh) * | 2021-09-27 | 2022-01-14 | 兰州大学 | 一种脐带干细胞来源外泌体的提取及水凝胶的制备方法 |
| CN113862220B (zh) * | 2021-11-05 | 2024-02-13 | 杭州隽和生物医药有限公司 | 间充质干细胞外泌体的制备及其应用 |
| CN114540268B (zh) * | 2022-01-05 | 2024-07-23 | 陕西微泌生物科技有限公司 | 一种基于超纯固膜技术的植物外泌体复合物的制备方法 |
| MX2024010560A (es) * | 2022-02-28 | 2024-09-06 | Jlm Exograde Llc | Metodo para enriquecer celulas muse, y obtener exosomas, microvesiculas o el secretoma a partir de las mismas. |
| CN114591901B (zh) * | 2022-03-24 | 2023-11-24 | 和携科技有限公司 | 动物脐带间充质干细胞外泌体提取方法 |
| CN114699550A (zh) * | 2022-03-29 | 2022-07-05 | 湖南有美生物科技有限公司 | 一种含绿茶外泌体的抗hpv功能性妇科敷料及其制备方法 |
| JP7598150B2 (ja) * | 2022-03-30 | 2024-12-11 | 株式会社山田養蜂場本社 | エクソソーム分泌促進剤 |
| CN115025288B (zh) * | 2022-06-17 | 2023-06-13 | 中南大学湘雅医院 | 一种外泌体水凝胶混合体系及其制备方法 |
| JP7220938B1 (ja) | 2022-09-28 | 2023-02-13 | パナジー株式会社 | 微小粒子、ｎｋ細胞活性化剤、ｎｋ細胞の培養方法、活性化ｎｋ細胞の製造方法およびｎｋ細胞の活性化方法 |
| CN115537390B (zh) * | 2022-10-28 | 2025-02-18 | 山东医科元多能干细胞生物工程有限公司 | 一种干细胞外泌体及旁分泌活性大分子连续化生产方法 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| GB2388189B (en) | 2002-04-29 | 2006-01-11 | Robert Jeffrey Geddes Carr | Optical detection and analysis of particles |
| ES2304069B1 (es) | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
| CN102014934B (zh) * | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| EP2663316A2 (en) * | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| SG11201406336YA (en) * | 2012-04-03 | 2014-11-27 | Reneuron Ltd | Stem cell microparticles |
-
2015
- 2015-11-02 US US14/929,578 patent/US20170121685A1/en not_active Abandoned
-
2016
- 2016-11-02 CA CA3003603A patent/CA3003603A1/en active Pending
- 2016-11-02 HK HK18114052.6A patent/HK1254948A1/zh unknown
- 2016-11-02 WO PCT/EP2016/076462 patent/WO2017076924A1/en not_active Ceased
- 2016-11-02 EP EP16808572.8A patent/EP3371298A1/en active Pending
- 2016-11-02 IL IL259147A patent/IL259147B/en unknown
- 2016-11-02 JP JP2018522514A patent/JP7069011B2/ja active Active
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