IL259147B - Mesenchymal stem cell-derived exosomes and their uses - Google Patents
Mesenchymal stem cell-derived exosomes and their usesInfo
- Publication number
- IL259147B IL259147B IL259147A IL25914718A IL259147B IL 259147 B IL259147 B IL 259147B IL 259147 A IL259147 A IL 259147A IL 25914718 A IL25914718 A IL 25914718A IL 259147 B IL259147 B IL 259147B
- Authority
- IL
- Israel
- Prior art keywords
- exosomes
- particular embodiment
- kda
- molecular weight
- tgf
- Prior art date
Links
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P37/00—Drugs for immunological or allergic disorders
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Applications Claiming Priority (2)
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| US14/929,578 US20170121685A1 (en) | 2015-11-02 | 2015-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
| PCT/EP2016/076462 WO2017076924A1 (en) | 2015-11-02 | 2016-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
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| IL259147A IL259147A (en) | 2018-06-28 |
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| IL259147A IL259147B (en) | 2015-11-02 | 2016-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
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| EP (1) | EP3371298A1 (https=) |
| JP (1) | JP7069011B2 (https=) |
| CA (1) | CA3003603A1 (https=) |
| HK (1) | HK1254948A1 (https=) |
| IL (1) | IL259147B (https=) |
| WO (1) | WO2017076924A1 (https=) |
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| US9919011B2 (en) * | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| KR20190003316A (ko) * | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| FR3068361B1 (fr) | 2017-06-30 | 2021-10-15 | Univ Paris Diderot Paris 7 | Systeme fluidique de production de vesicules extracellulaires et procede associe |
| KR20190011213A (ko) * | 2017-07-24 | 2019-02-01 | 한양대학교 에리카산학협력단 | 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물 |
| US11766402B2 (en) | 2017-11-16 | 2023-09-26 | Board Of Regents, The University Of Texas System | Methods for production of MSC-derived exosomes |
| WO2019105082A1 (zh) * | 2017-11-30 | 2019-06-06 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| US20210161967A1 (en) * | 2017-12-06 | 2021-06-03 | Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" | Extracellular vesicles and uses thereof |
| US12257266B2 (en) | 2018-03-02 | 2025-03-25 | The Regents Of The University Of California | Stem cell-derived exosomes for the treatment of corneal scarring |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法 |
| CN108865985A (zh) * | 2018-06-22 | 2018-11-23 | 山东省职业卫生与职业病防治研究院 | 一种干细胞源外泌体干预上皮-间质转化的方法 |
| CN109161526A (zh) * | 2018-10-12 | 2019-01-08 | 希瑞干细胞科技有限公司 | 一种绒毛膜间充质干细胞复苏培养基 |
| BR112021015549A2 (pt) | 2019-02-07 | 2021-10-26 | Direct Biologics Llc | Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes |
| EP3927317A4 (en) * | 2019-02-19 | 2022-08-10 | Direct Biologics, LLC | ACELLULAR INTRAVENOUS INFUSION WITH GROWTH FACTORS FROM MESENCHYMAL STEM CELLS AND EXOSOMES |
| US12350293B2 (en) | 2019-03-08 | 2025-07-08 | Niigata University | Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition |
| KR102132457B1 (ko) * | 2019-05-10 | 2020-07-09 | 주식회사 바이오솔루션 | 세포외 소포를 고농도로 배양하기 위한 세포 배양배지 및 상기 세포 배양배지를 이용한 세포외 소포 고 함유 조건화 배양액의 제조방법 |
| CN110184235B (zh) * | 2019-05-21 | 2021-03-02 | 葛楠 | 一种adsc外泌体及其制备方法与应用 |
| CN118147051A (zh) * | 2019-06-10 | 2024-06-07 | 布瑞克斯奥根株式会社 | 用于促进干细胞来源外泌体产生和增加干性的包含白藜芦醇的组合物 |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| CN110946876A (zh) * | 2019-10-28 | 2020-04-03 | 天津市康婷生物工程集团有限公司 | 间充质干细胞外泌体制剂在治疗斑秃中的应用 |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| KR102319735B1 (ko) * | 2020-04-28 | 2021-11-01 | 건국대학교 산학협력단 | 3차원 배양된 줄기세포로부터 세포외 소포체를 제조하는 방법 |
| WO2021251616A1 (ko) * | 2020-06-10 | 2021-12-16 | 재단법인 대구경북첨단의료산업진흥재단 | 고양이과 동물 중간엽 줄기세포 유래 엑소좀을 포함하는 조성물 및 이를 이용한 염증질환 치료방법 |
| JP2023537204A (ja) * | 2020-07-09 | 2023-08-31 | エクソ バイオロジクス エスアー | 間葉系ストローマ細胞由来の細胞外小胞（ｅｖ）および前記ｅｖを得るための方法 |
| CN111849882A (zh) * | 2020-07-17 | 2020-10-30 | 尧舜泽生物医药(南京)有限公司 | 间充质干细胞外泌体及其制备方法和应用 |
| CN111944747A (zh) * | 2020-08-14 | 2020-11-17 | 福建医科大学附属协和医院 | 一种用于治疗心肌梗死的人脂肪间充质干细胞外泌体及其用途 |
| EP4212163A4 (en) | 2020-09-08 | 2024-09-18 | Dexon Pharmaceuticals Inc. | CYTOKINE STORM INHIBITOR, METHOD FOR USING CYTOKINE STORM INHIBITOR, AND METHOD FOR SCREENING CYTOKINE INHIBITOR |
| WO2022080461A1 (ja) * | 2020-10-16 | 2022-04-21 | 富士フイルム和光純薬株式会社 | 細胞外小胞の産生用培地、培地キット、添加剤及び細胞外小胞の産生方法 |
| CN116888126B (zh) * | 2020-12-15 | 2026-03-17 | 北京原基华毅生物科技有限公司 | 一种酪蛋白激酶抑制剂的化合物 |
| CN115029317B (zh) * | 2021-02-23 | 2025-10-28 | 赛浦生物科技(长春)有限公司 | 用于过敏性鼻炎的鼻喷雾剂及制备方法 |
| CN112915105B (zh) * | 2021-03-12 | 2024-07-19 | 上海市第六人民医院 | 间充质干细胞分泌的小细胞外囊泡在制备治疗cp/cpps的药物上的应用 |
| CN112961240B (zh) * | 2021-04-06 | 2022-07-05 | 明济生物制药（北京）有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| CN113174363B (zh) * | 2021-04-21 | 2023-05-30 | 天晴干细胞股份有限公司 | 用于促进iPSC分化为胰岛素分泌细胞的混合物及其制备方法 |
| CN113846047A (zh) * | 2021-06-22 | 2021-12-28 | 姜海涛 | 一种肾靶向载药外泌体及应用和治疗肾脏疾病药物 |
| CN114164172A (zh) * | 2021-08-27 | 2022-03-11 | 广州百暨基因科技有限公司 | 间充质干细胞外泌体的制备方法 |
| CN113930393A (zh) * | 2021-09-27 | 2022-01-14 | 兰州大学 | 一种脐带干细胞来源外泌体的提取及水凝胶的制备方法 |
| CN113862220B (zh) * | 2021-11-05 | 2024-02-13 | 杭州隽和生物医药有限公司 | 间充质干细胞外泌体的制备及其应用 |
| CN114540268B (zh) * | 2022-01-05 | 2024-07-23 | 陕西微泌生物科技有限公司 | 一种基于超纯固膜技术的植物外泌体复合物的制备方法 |
| MX2024010560A (es) * | 2022-02-28 | 2024-09-06 | Jlm Exograde Llc | Metodo para enriquecer celulas muse, y obtener exosomas, microvesiculas o el secretoma a partir de las mismas. |
| CN114591901B (zh) * | 2022-03-24 | 2023-11-24 | 和携科技有限公司 | 动物脐带间充质干细胞外泌体提取方法 |
| CN114699550A (zh) * | 2022-03-29 | 2022-07-05 | 湖南有美生物科技有限公司 | 一种含绿茶外泌体的抗hpv功能性妇科敷料及其制备方法 |
| JP7598150B2 (ja) * | 2022-03-30 | 2024-12-11 | 株式会社山田養蜂場本社 | エクソソーム分泌促進剤 |
| CN115025288B (zh) * | 2022-06-17 | 2023-06-13 | 中南大学湘雅医院 | 一种外泌体水凝胶混合体系及其制备方法 |
| JP7220938B1 (ja) | 2022-09-28 | 2023-02-13 | パナジー株式会社 | 微小粒子、ｎｋ細胞活性化剤、ｎｋ細胞の培養方法、活性化ｎｋ細胞の製造方法およびｎｋ細胞の活性化方法 |
| CN115537390B (zh) * | 2022-10-28 | 2025-02-18 | 山东医科元多能干细胞生物工程有限公司 | 一种干细胞外泌体及旁分泌活性大分子连续化生产方法 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| GB2388189B (en) | 2002-04-29 | 2006-01-11 | Robert Jeffrey Geddes Carr | Optical detection and analysis of particles |
| ES2304069B1 (es) | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
| CN102014934B (zh) * | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| EP2663316A2 (en) * | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| SG11201406336YA (en) * | 2012-04-03 | 2014-11-27 | Reneuron Ltd | Stem cell microparticles |
-
2015
- 2015-11-02 US US14/929,578 patent/US20170121685A1/en not_active Abandoned
-
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- 2016-11-02 CA CA3003603A patent/CA3003603A1/en active Pending
- 2016-11-02 HK HK18114052.6A patent/HK1254948A1/zh unknown
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- 2016-11-02 JP JP2018522514A patent/JP7069011B2/ja active Active
Non-Patent Citations (2)
| Title |
|---|
| ALVAREZ, V, ESTUDIO COMPARATIVO DEL AISLAMIENTO DE EXOSOMAS DERIVADOS DE CELULAS MADRE MESENQUIMALES HUMANAS PARA USO CLINICO., 30 September 2015 (2015-09-30) * |
| BLAZQUEZ, R, MMUNOMODULATORY POTENTIAL OF HUMAN ADIPOSE MESENCHYMAL STEM CELLS DERIVED EXOSOMES ON IN VITRO STIMULATED T CELLS., 4 November 2014 (2014-11-04) * |
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| JP7069011B2 (ja) | 2022-05-17 |
| HK1254948A1 (zh) | 2019-08-02 |
| US20170121685A1 (en) | 2017-05-04 |
| WO2017076924A9 (en) | 2017-07-27 |
| JP2018531979A (ja) | 2018-11-01 |
| WO2017076924A1 (en) | 2017-05-11 |
| IL259147A (en) | 2018-06-28 |
| CA3003603A1 (en) | 2017-05-11 |
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