HK1254948A1 - 源自間充質幹細胞的外泌體及其應用 - Google Patents

源自間充質幹細胞的外泌體及其應用

Info

Publication number
HK1254948A1
HK1254948A1 HK18114052.6A HK18114052A HK1254948A1 HK 1254948 A1 HK1254948 A1 HK 1254948A1 HK 18114052 A HK18114052 A HK 18114052A HK 1254948 A1 HK1254948 A1 HK 1254948A1
Authority
HK
Hong Kong
Prior art keywords
stem cell
mesenchymal stem
derived exosomes
exosomes
derived
Prior art date
Application number
HK18114052.6A
Other languages
English (en)
Inventor
La Rosa Olga De
Eleuterio Lombardo
Wilfried Dalemans
CASADO Javier GARCÍA
DURÁN Rebeca BLÁZQUEZ
Margallo Francisco Miguel Sánchez
Original Assignee
Tigenix S A U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix S A U filed Critical Tigenix S A U
Publication of HK1254948A1 publication Critical patent/HK1254948A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK18114052.6A 2015-11-02 2018-11-02 源自間充質幹細胞的外泌體及其應用 HK1254948A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/929,578 US20170121685A1 (en) 2015-11-02 2015-11-02 Mesenchymal stem cell-derived exosomes and their uses
PCT/EP2016/076462 WO2017076924A1 (en) 2015-11-02 2016-11-02 Mesenchymal stem cell-derived exosomes and their uses

Publications (1)

Publication Number Publication Date
HK1254948A1 true HK1254948A1 (zh) 2019-08-02

Family

ID=57517849

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114052.6A HK1254948A1 (zh) 2015-11-02 2018-11-02 源自間充質幹細胞的外泌體及其應用

Country Status (7)

Country Link
US (1) US20170121685A1 (zh)
EP (1) EP3371298A1 (zh)
JP (1) JP7069011B2 (zh)
CA (1) CA3003603A1 (zh)
HK (1) HK1254948A1 (zh)
IL (1) IL259147B (zh)
WO (1) WO2017076924A1 (zh)

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US9919011B2 (en) * 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
FR3068361B1 (fr) * 2017-06-30 2021-10-15 Univ Paris Diderot Paris 7 Systeme fluidique de production de vesicules extracellulaires et procede associe
KR20190003316A (ko) * 2017-06-30 2019-01-09 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도
KR20190011213A (ko) * 2017-07-24 2019-02-01 한양대학교 에리카산학협력단 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물
JP2021503286A (ja) 2017-11-16 2021-02-12 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｍｓｃ由来エキソソームの製造方法
WO2019105082A1 (zh) * 2017-11-30 2019-06-06 苏州科睿思制药有限公司 Galunisertib的晶型及其制备方法和用途
US20210161967A1 (en) * 2017-12-06 2021-06-03 Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" Extracellular vesicles and uses thereof
CN108865985A (zh) * 2018-06-22 2018-11-23 山东省职业卫生与职业病防治研究院 一种干细胞源外泌体干预上皮-间质转化的方法
CN109161526A (zh) * 2018-10-12 2019-01-08 希瑞干细胞科技有限公司 一种绒毛膜间充质干细胞复苏培养基
US20220062347A1 (en) * 2019-03-08 2022-03-03 Niigata University Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition
CN110184235B (zh) * 2019-05-21 2021-03-02 葛楠 一种adsc外泌体及其制备方法与应用
CN118147051A (zh) * 2019-06-10 2024-06-07 布瑞克斯奥根株式会社 用于促进干细胞来源外泌体产生和增加干性的包含白藜芦醇的组合物
CN110946876A (zh) * 2019-10-28 2020-04-03 天津市康婷生物工程集团有限公司 间充质干细胞外泌体制剂在治疗斑秃中的应用
KR102319735B1 (ko) * 2020-04-28 2021-11-01 건국대학교 산학협력단 3차원 배양된 줄기세포로부터 세포외 소포체를 제조하는 방법
WO2021251616A1 (ko) * 2020-06-10 2021-12-16 재단법인 대구경북첨단의료산업진흥재단 고양이과 동물 중간엽 줄기세포 유래 엑소좀을 포함하는 조성물 및 이를 이용한 염증질환 치료방법
CN111849882A (zh) * 2020-07-17 2020-10-30 尧舜泽生物医药(南京)有限公司 间充质干细胞外泌体及其制备方法和应用
CN111944747A (zh) * 2020-08-14 2020-11-17 福建医科大学附属协和医院 一种用于治疗心肌梗死的人脂肪间充质干细胞外泌体及其用途
CN116171158A (zh) 2020-09-08 2023-05-26 Dexon制药株式会社 细胞因子风暴抑制剂、细胞因子风暴抑制剂的使用方法和筛选方法
EP4230724A4 (en) * 2020-10-16 2024-05-22 FUJIFILM Corporation CULTURE MEDIUM FOR THE PRODUCTION OF EXTRACELLULAR VESICLES, CULTURE MEDIUM KIT, ADDITIVE AND METHOD FOR THE PRODUCTION OF EXTRACELLULAR VESICLES
CN116888126A (zh) * 2020-12-15 2023-10-13 北京原基华毅生物科技有限公司 一种酪蛋白激酶抑制剂的化合物
CN112877294B (zh) * 2021-02-23 2021-08-24 赛浦生物科技(长春)有限公司 基因修饰的间充质干细胞外泌体的制备及其应用
CN112915105B (zh) * 2021-03-12 2024-07-19 上海市第六人民医院 间充质干细胞分泌的小细胞外囊泡在制备治疗cp/cpps的药物上的应用
CN112961240B (zh) * 2021-04-06 2022-07-05 明济生物制药（北京）有限公司 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用
CN113174363B (zh) * 2021-04-21 2023-05-30 天晴干细胞股份有限公司 用于促进iPSC分化为胰岛素分泌细胞的混合物及其制备方法
CN113846047A (zh) * 2021-06-22 2021-12-28 姜海涛 一种肾靶向载药外泌体及应用和治疗肾脏疾病药物
CN114164172A (zh) * 2021-08-27 2022-03-11 广州百暨基因科技有限公司 间充质干细胞外泌体的制备方法
CN113930393A (zh) * 2021-09-27 2022-01-14 兰州大学 一种脐带干细胞来源外泌体的提取及水凝胶的制备方法
CN113862220B (zh) * 2021-11-05 2024-02-13 杭州隽和生物医药有限公司 间充质干细胞外泌体的制备及其应用
CN114540268B (zh) * 2022-01-05 2024-07-23 陕西微泌生物科技有限公司 一种基于超纯固膜技术的植物外泌体复合物的制备方法
CN114591901B (zh) * 2022-03-24 2023-11-24 和携科技有限公司 动物脐带间充质干细胞外泌体提取方法
CN114699550A (zh) * 2022-03-29 2022-07-05 湖南有美生物科技有限公司 一种含绿茶外泌体的抗hpv功能性妇科敷料及其制备方法
CN115025288B (zh) * 2022-06-17 2023-06-13 中南大学湘雅医院 一种外泌体水凝胶混合体系及其制备方法
JP7220938B1 (ja) 2022-09-28 2023-02-13 パナジー株式会社 微小粒子、ｎｋ細胞活性化剤、ｎｋ細胞の培養方法、活性化ｎｋ細胞の製造方法およびｎｋ細胞の活性化方法
CN115537390A (zh) * 2022-10-28 2022-12-30 山东医科元多能干细胞生物工程有限公司 一种干细胞外泌体及旁分泌活性大分子连续化生产方法

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Also Published As

Publication number Publication date
EP3371298A1 (en) 2018-09-12
CA3003603A1 (en) 2017-05-11
WO2017076924A1 (en) 2017-05-11
JP2018531979A (ja) 2018-11-01
IL259147B (en) 2022-07-01
US20170121685A1 (en) 2017-05-04
WO2017076924A9 (en) 2017-07-27
IL259147A (en) 2018-06-28
JP7069011B2 (ja) 2022-05-17

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