HK1254948A1 - 源自间充质干细胞的外泌体及其应用 - Google Patents

源自间充质干细胞的外泌体及其应用 Download PDF

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Publication number
HK1254948A1
HK1254948A1 HK18114052.6A HK18114052A HK1254948A1 HK 1254948 A1 HK1254948 A1 HK 1254948A1 HK 18114052 A HK18114052 A HK 18114052A HK 1254948 A1 HK1254948 A1 HK 1254948A1
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Hong Kong
Prior art keywords
mesenchymal stem
stem cell
derived exosomes
isolated
exosome
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HK18114052.6A
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English (en)
Chinese (zh)
Inventor
Olga De La Rosa
Eleuterio Lombardo
Wilfried Dalemans
Javier GARCÍA CASADO
Rebeca BLÁZQUEZ DURÁN
Francisco Miguel Sánchez Margallo
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Takeda Pharmaceutical Company Limited
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Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of HK1254948A1 publication Critical patent/HK1254948A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18114052.6A 2015-11-02 2016-11-02 源自间充质干细胞的外泌体及其应用 HK1254948A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/929,578 US20170121685A1 (en) 2015-11-02 2015-11-02 Mesenchymal stem cell-derived exosomes and their uses
US14/929,578 2015-11-02
PCT/EP2016/076462 WO2017076924A1 (en) 2015-11-02 2016-11-02 Mesenchymal stem cell-derived exosomes and their uses

Publications (1)

Publication Number Publication Date
HK1254948A1 true HK1254948A1 (zh) 2019-08-02

Family

ID=57517849

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114052.6A HK1254948A1 (zh) 2015-11-02 2016-11-02 源自间充质干细胞的外泌体及其应用

Country Status (7)

Country Link
US (1) US20170121685A1 (https=)
EP (1) EP3371298A1 (https=)
JP (1) JP7069011B2 (https=)
CA (1) CA3003603A1 (https=)
HK (1) HK1254948A1 (https=)
IL (1) IL259147B (https=)
WO (1) WO2017076924A1 (https=)

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WO2019105082A1 (zh) * 2017-11-30 2019-06-06 苏州科睿思制药有限公司 Galunisertib的晶型及其制备方法和用途
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US12257266B2 (en) 2018-03-02 2025-03-25 The Regents Of The University Of California Stem cell-derived exosomes for the treatment of corneal scarring
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KR102132457B1 (ko) * 2019-05-10 2020-07-09 주식회사 바이오솔루션 세포외 소포를 고농도로 배양하기 위한 세포 배양배지 및 상기 세포 배양배지를 이용한 세포외 소포 고 함유 조건화 배양액의 제조방법
CN110184235B (zh) * 2019-05-21 2021-03-02 葛楠 一种adsc外泌体及其制备方法与应用
CN118147051A (zh) * 2019-06-10 2024-06-07 布瑞克斯奥根株式会社 用于促进干细胞来源外泌体产生和增加干性的包含白藜芦醇的组合物
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CN116888126B (zh) * 2020-12-15 2026-03-17 北京原基华毅生物科技有限公司 一种酪蛋白激酶抑制剂的化合物
CN115029317B (zh) * 2021-02-23 2025-10-28 赛浦生物科技(长春)有限公司 用于过敏性鼻炎的鼻喷雾剂及制备方法
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CN113930393A (zh) * 2021-09-27 2022-01-14 兰州大学 一种脐带干细胞来源外泌体的提取及水凝胶的制备方法
CN113862220B (zh) * 2021-11-05 2024-02-13 杭州隽和生物医药有限公司 间充质干细胞外泌体的制备及其应用
CN114540268B (zh) * 2022-01-05 2024-07-23 陕西微泌生物科技有限公司 一种基于超纯固膜技术的植物外泌体复合物的制备方法
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CN114591901B (zh) * 2022-03-24 2023-11-24 和携科技有限公司 动物脐带间充质干细胞外泌体提取方法
CN114699550A (zh) * 2022-03-29 2022-07-05 湖南有美生物科技有限公司 一种含绿茶外泌体的抗hpv功能性妇科敷料及其制备方法
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Also Published As

Publication number Publication date
EP3371298A1 (en) 2018-09-12
IL259147B (en) 2022-07-01
JP7069011B2 (ja) 2022-05-17
US20170121685A1 (en) 2017-05-04
WO2017076924A9 (en) 2017-07-27
JP2018531979A (ja) 2018-11-01
WO2017076924A1 (en) 2017-05-11
IL259147A (en) 2018-06-28
CA3003603A1 (en) 2017-05-11

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