JP6976335B2 - 組み換え結合タンパク質及びその使用 - Google Patents
組み換え結合タンパク質及びその使用 Download PDFInfo
- Publication number
- JP6976335B2 JP6976335B2 JP2019536693A JP2019536693A JP6976335B2 JP 6976335 B2 JP6976335 B2 JP 6976335B2 JP 2019536693 A JP2019536693 A JP 2019536693A JP 2019536693 A JP2019536693 A JP 2019536693A JP 6976335 B2 JP6976335 B2 JP 6976335B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- her2
- binding protein
- ankyrin repeat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16190221.8 | 2016-09-22 | ||
| EP16190221 | 2016-09-22 | ||
| PCT/EP2017/073768 WO2018054971A1 (en) | 2016-09-22 | 2017-09-20 | Recombinant binding proteins and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531093A JP2019531093A (ja) | 2019-10-31 |
| JP2019531093A5 JP2019531093A5 (enExample) | 2020-05-21 |
| JP6976335B2 true JP6976335B2 (ja) | 2021-12-08 |
Family
ID=57046984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536693A Expired - Fee Related JP6976335B2 (ja) | 2016-09-22 | 2017-09-20 | 組み換え結合タンパク質及びその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10717772B2 (enExample) |
| EP (1) | EP3515933B9 (enExample) |
| JP (1) | JP6976335B2 (enExample) |
| KR (1) | KR102270315B1 (enExample) |
| CN (1) | CN109790206A (enExample) |
| AR (1) | AR109680A1 (enExample) |
| AU (1) | AU2017331329B2 (enExample) |
| BR (1) | BR112019005587A2 (enExample) |
| CA (1) | CA3036301C (enExample) |
| CL (1) | CL2019000729A1 (enExample) |
| CO (1) | CO2019002609A2 (enExample) |
| ES (1) | ES2953516T3 (enExample) |
| IL (1) | IL265489B (enExample) |
| MX (1) | MX377424B (enExample) |
| MY (1) | MY196882A (enExample) |
| NZ (1) | NZ751689A (enExample) |
| PH (1) | PH12019500596B1 (enExample) |
| SA (1) | SA519401369B1 (enExample) |
| WO (1) | WO2018054971A1 (enExample) |
| ZA (1) | ZA201901592B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020286600A1 (en) * | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Recombinant FAP binding proteins and their use |
| AU2020289080A1 (en) * | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Multispecific proteins |
| EP3980452A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant 4-1bb binding proteins and their use |
| CA3138805A1 (en) | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| CN114929730A (zh) | 2019-12-11 | 2022-08-19 | 分子合作伙伴股份公司 | 重组肽-mhc复合物结合蛋白及其生成和用途 |
| MX2022013945A (es) * | 2020-05-06 | 2023-02-14 | Molecular Partners Ag | Nuevas proteinas de union a repeticiones de anquirina y sus usos. |
| JP2023528204A (ja) | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 多選択性タンパク質 |
| US20240279309A1 (en) * | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| WO2022130300A1 (en) | 2020-12-16 | 2022-06-23 | Molecular Partners Ag | Novel slow-release prodrugs |
| JP2024509904A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ |
| US20240156980A1 (en) | 2021-03-09 | 2024-05-16 | Molecular Partners Ag | Protease cleavable prodrugs |
| EP4304730A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Novel darpin based cd33 engagers |
| AU2022233791A1 (en) | 2021-03-09 | 2023-09-28 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| IL313411A (en) | 2021-12-14 | 2024-08-01 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| CN119731200A (zh) | 2022-08-01 | 2025-03-28 | 分子合作伙伴股份公司 | 经电荷修饰设计的重复结构域及其用途 |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| EP4665755A1 (en) | 2023-02-17 | 2025-12-24 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| CN121263440A (zh) | 2023-06-06 | 2026-01-02 | 分子合作伙伴股份公司 | 重组cd2结合蛋白及其用途 |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025163144A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
| WO2026013280A1 (en) * | 2024-07-11 | 2026-01-15 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Designed ankyrin repeat proteins binding p53, and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2421447C (en) | 2000-09-08 | 2012-05-08 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| PT1567641E (pt) * | 2001-08-24 | 2012-08-21 | Uvic Industry Partnerships Inc | Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata |
| CN101875919A (zh) | 2004-11-12 | 2010-11-03 | 拜耳先灵医药股份有限公司 | 重组新城疫病毒 |
| RU2412249C2 (ru) | 2005-07-08 | 2011-02-20 | Юниверсити Оф Цюрих | Фаговый дисплей с применением котрансляционной транслокации слитых полипептидов |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| EP2358746B1 (en) | 2008-11-03 | 2020-09-16 | Molecular Partners AG | Binding proteins inhibiting the vegf-a receptor interaction |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| EP2643349B1 (en) * | 2010-11-26 | 2019-09-04 | Molecular Partners AG | Designed repeat proteins binding to serum albumin |
| KR20140039203A (ko) | 2011-04-29 | 2014-04-01 | 얀센 바이오테크 인코포레이티드 | Il4/il13 결합 반복 단백질 및 용도 |
| WO2014001442A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| JP2015532306A (ja) * | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| US9458211B1 (en) * | 2015-04-02 | 2016-10-04 | Molecular Partners Ag | Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains |
-
2017
- 2017-09-20 AR ARP170102593A patent/AR109680A1/es not_active Application Discontinuation
- 2017-09-20 EP EP17778226.5A patent/EP3515933B9/en active Active
- 2017-09-20 CA CA3036301A patent/CA3036301C/en active Active
- 2017-09-20 MY MYPI2019001523A patent/MY196882A/en unknown
- 2017-09-20 WO PCT/EP2017/073768 patent/WO2018054971A1/en not_active Ceased
- 2017-09-20 KR KR1020197009396A patent/KR102270315B1/ko not_active Expired - Fee Related
- 2017-09-20 CN CN201780058511.0A patent/CN109790206A/zh active Pending
- 2017-09-20 AU AU2017331329A patent/AU2017331329B2/en not_active Ceased
- 2017-09-20 PH PH1/2019/500596A patent/PH12019500596B1/en unknown
- 2017-09-20 US US15/710,001 patent/US10717772B2/en active Active
- 2017-09-20 JP JP2019536693A patent/JP6976335B2/ja not_active Expired - Fee Related
- 2017-09-20 ES ES17778226T patent/ES2953516T3/es active Active
- 2017-09-20 MX MX2019003298A patent/MX377424B/es active IP Right Grant
- 2017-09-20 BR BR112019005587A patent/BR112019005587A2/pt not_active Application Discontinuation
- 2017-09-20 NZ NZ751689A patent/NZ751689A/en not_active IP Right Cessation
-
2019
- 2019-03-14 ZA ZA2019/01592A patent/ZA201901592B/en unknown
- 2019-03-19 IL IL265489A patent/IL265489B/en unknown
- 2019-03-20 SA SA519401369A patent/SA519401369B1/ar unknown
- 2019-03-21 CO CONC2019/0002609A patent/CO2019002609A2/es unknown
- 2019-03-21 CL CL2019000729A patent/CL2019000729A1/es unknown
-
2020
- 2020-06-22 US US16/907,415 patent/US20210130420A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6976335B2 (ja) | 組み換え結合タンパク質及びその使用 | |
| KR102290592B1 (ko) | Her2에 대항하는 적어도 두 개 이상의 반복 도메인을 포함하는 결합 단백질 | |
| KR20100128291A (ko) | Ｅｇｆｒ에 결합하는 조작된 단백질을 기초로 하는 표적화된 치료제 | |
| JP2018511327A (ja) | 血清アルブミンに対する結合特異性を有する設計アンキリンリピートドメイン | |
| JP2024509241A (ja) | 新規のＤＡＲＰｉｎに基づくＣＤ１２３エンゲージャ | |
| JP2024513559A (ja) | 新規なＤＡＲＰｉｎベースのＣＤ７０エンゲージャー | |
| JP2024508969A (ja) | 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ | |
| JP2023554379A (ja) | 組換えｃｄ３結合タンパク質及びそれらの使用 | |
| RU2778346C2 (ru) | Рекомбинантные связывающие белки и их применение | |
| CN117242100A (zh) | 基于DARPin的新型CD70接合物 | |
| HK40006908A (en) | Recombinant binding proteins and their use | |
| HK40006908B (en) | Recombinant binding proteins and their use | |
| CN116802213A (zh) | 重组cd3结合蛋白及其用途 | |
| CN117255803A (zh) | 基于DARPin的新型CD33接合物 | |
| CN121263440A (zh) | 重组cd2结合蛋白及其用途 | |
| CN117177996A (zh) | 基于DARPin的新型CD123接合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200409 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200409 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20200409 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20200527 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200609 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200821 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201208 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210202 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210531 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210531 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20210615 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210705 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210818 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210824 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211012 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211109 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6976335 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |