KR102270315B1 - 재조합 결합 단백질 및 그의 용도 - Google Patents

재조합 결합 단백질 및 그의 용도 Download PDF

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Publication number
KR102270315B1
KR102270315B1 KR1020197009396A KR20197009396A KR102270315B1 KR 102270315 B1 KR102270315 B1 KR 102270315B1 KR 1020197009396 A KR1020197009396 A KR 1020197009396A KR 20197009396 A KR20197009396 A KR 20197009396A KR 102270315 B1 KR102270315 B1 KR 102270315B1
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protein
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KR20190050802A (ko
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클라라 메츠
울리케 피들러
이그나시오 도라도
헤이크 마리아 스트로벨
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몰리큘라 파트너스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197009396A 2016-09-22 2017-09-20 재조합 결합 단백질 및 그의 용도 Expired - Fee Related KR102270315B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16190221.8 2016-09-22
EP16190221 2016-09-22
PCT/EP2017/073768 WO2018054971A1 (en) 2016-09-22 2017-09-20 Recombinant binding proteins and their use

Publications (2)

Publication Number Publication Date
KR20190050802A KR20190050802A (ko) 2019-05-13
KR102270315B1 true KR102270315B1 (ko) 2021-06-29

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Country Status (20)

Country Link
US (2) US10717772B2 (enExample)
EP (1) EP3515933B9 (enExample)
JP (1) JP6976335B2 (enExample)
KR (1) KR102270315B1 (enExample)
CN (1) CN109790206A (enExample)
AR (1) AR109680A1 (enExample)
AU (1) AU2017331329B2 (enExample)
BR (1) BR112019005587A2 (enExample)
CA (1) CA3036301C (enExample)
CL (1) CL2019000729A1 (enExample)
CO (1) CO2019002609A2 (enExample)
ES (1) ES2953516T3 (enExample)
IL (1) IL265489B (enExample)
MX (1) MX377424B (enExample)
MY (1) MY196882A (enExample)
NZ (1) NZ751689A (enExample)
PH (1) PH12019500596B1 (enExample)
SA (1) SA519401369B1 (enExample)
WO (1) WO2018054971A1 (enExample)
ZA (1) ZA201901592B (enExample)

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AU2020289080A1 (en) * 2019-06-04 2021-12-23 Molecular Partners Ag Multispecific proteins
EP3980452A1 (en) * 2019-06-04 2022-04-13 Molecular Partners AG Recombinant 4-1bb binding proteins and their use
CA3138805A1 (en) 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
CN114929730A (zh) 2019-12-11 2022-08-19 分子合作伙伴股份公司 重组肽-mhc复合物结合蛋白及其生成和用途
MX2022013945A (es) * 2020-05-06 2023-02-14 Molecular Partners Ag Nuevas proteinas de union a repeticiones de anquirina y sus usos.
JP2023528204A (ja) 2020-05-14 2023-07-04 モレキュラー パートナーズ アクチェンゲゼルシャフト 多選択性タンパク質
US20240279309A1 (en) * 2020-05-14 2024-08-22 Molecular Partners Ag Recombinant cd40 binding proteins and their use
WO2022130300A1 (en) 2020-12-16 2022-06-23 Molecular Partners Ag Novel slow-release prodrugs
JP2024509904A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ
US20240156980A1 (en) 2021-03-09 2024-05-16 Molecular Partners Ag Protease cleavable prodrugs
EP4304730A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Novel darpin based cd33 engagers
AU2022233791A1 (en) 2021-03-09 2023-09-28 Molecular Partners Ag Novel darpin based cd123 engagers
IL313411A (en) 2021-12-14 2024-08-01 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
CN119731200A (zh) 2022-08-01 2025-03-28 分子合作伙伴股份公司 经电荷修饰设计的重复结构域及其用途
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
EP4665755A1 (en) 2023-02-17 2025-12-24 Ablynx N.V. Polypeptides binding to the neonatal fc receptor
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
CN121263440A (zh) 2023-06-06 2026-01-02 分子合作伙伴股份公司 重组cd2结合蛋白及其用途
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2026013280A1 (en) * 2024-07-11 2026-01-15 Johann Wolfgang Goethe-Universität Frankfurt am Main Designed ankyrin repeat proteins binding p53, and uses thereof

Citations (1)

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SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
CA2421447C (en) 2000-09-08 2012-05-08 Universitat Zurich Collections of repeat proteins comprising repeat modules
PT1567641E (pt) * 2001-08-24 2012-08-21 Uvic Industry Partnerships Inc Proaerolisina contendo sequência de activação de proteases e métodos de uso para o tratamento do cancro da próstata
CN101875919A (zh) 2004-11-12 2010-11-03 拜耳先灵医药股份有限公司 重组新城疫病毒
RU2412249C2 (ru) 2005-07-08 2011-02-20 Юниверсити Оф Цюрих Фаговый дисплей с применением котрансляционной транслокации слитых полипептидов
CA2700391A1 (en) 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
CN101970490A (zh) 2007-11-27 2011-02-09 埃博灵克斯股份有限公司 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽
EP2358746B1 (en) 2008-11-03 2020-09-16 Molecular Partners AG Binding proteins inhibiting the vegf-a receptor interaction
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
EP2643349B1 (en) * 2010-11-26 2019-09-04 Molecular Partners AG Designed repeat proteins binding to serum albumin
KR20140039203A (ko) 2011-04-29 2014-04-01 얀센 바이오테크 인코포레이티드 Il4/il13 결합 반복 단백질 및 용도
WO2014001442A1 (en) 2012-06-28 2014-01-03 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
JP2015532306A (ja) * 2012-10-15 2015-11-09 チューリッヒ大学 癌治療のための二重特異性ｈｅｒ２リガンド
US11453708B2 (en) 2013-05-31 2022-09-27 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor
US9458211B1 (en) * 2015-04-02 2016-10-04 Molecular Partners Ag Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains

Patent Citations (1)

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JP2015537044A (ja) 2012-11-30 2015-12-24 モレキュラー パートナーズ アクチェンゲゼルシャフト 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質

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Publication number Publication date
EP3515933B1 (en) 2023-06-07
US20180155402A1 (en) 2018-06-07
CA3036301A1 (en) 2018-03-29
PH12019500596A1 (en) 2019-07-29
AU2017331329B2 (en) 2020-10-29
CO2019002609A2 (es) 2019-05-31
SA519401369B1 (ar) 2022-12-22
EP3515933C0 (en) 2023-06-07
AR109680A1 (es) 2019-01-09
BR112019005587A2 (pt) 2019-06-11
ZA201901592B (en) 2021-04-28
IL265489A (en) 2019-05-30
CA3036301C (en) 2021-04-20
RU2019111628A (ru) 2020-10-19
MY196882A (en) 2023-05-08
EP3515933A1 (en) 2019-07-31
WO2018054971A1 (en) 2018-03-29
CL2019000729A1 (es) 2019-06-14
EP3515933B9 (en) 2023-08-16
JP6976335B2 (ja) 2021-12-08
NZ751689A (en) 2021-07-30
IL265489B (en) 2021-07-29
PH12019500596B1 (en) 2024-02-21
US20210130420A1 (en) 2021-05-06
AU2017331329A1 (en) 2019-04-04
JP2019531093A (ja) 2019-10-31
KR20190050802A (ko) 2019-05-13
RU2019111628A3 (enExample) 2020-10-30
ES2953516T3 (es) 2023-11-14
MX377424B (es) 2025-03-10
MX2019003298A (es) 2019-09-26
US10717772B2 (en) 2020-07-21
CN109790206A (zh) 2019-05-21

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