JP6964065B2 - 液体クロマトグラフ質量分析装置 - Google Patents

液体クロマトグラフ質量分析装置 Download PDF

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JP6964065B2
JP6964065B2 JP2018230775A JP2018230775A JP6964065B2 JP 6964065 B2 JP6964065 B2 JP 6964065B2 JP 2018230775 A JP2018230775 A JP 2018230775A JP 2018230775 A JP2018230775 A JP 2018230775A JP 6964065 B2 JP6964065 B2 JP 6964065B2
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flow path
mass spectrometer
liquid
liquid chromatograph
chromatograph mass
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JP2020094817A5 (https=
JP2020094817A (ja
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益之 杉山
雄一郎 橋本
英樹 長谷川
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Hitachi High Tech Corp
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Hitachi High Tech Corp
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Priority to JP2018230775A priority Critical patent/JP6964065B2/ja
Priority to US17/296,317 priority patent/US11860142B2/en
Priority to EP19897194.7A priority patent/EP3896440B1/en
Priority to PCT/JP2019/042053 priority patent/WO2020121660A1/ja
Priority to CN201980077153.7A priority patent/CN114127551B/zh
Publication of JP2020094817A publication Critical patent/JP2020094817A/ja
Publication of JP2020094817A5 publication Critical patent/JP2020094817A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2018230775A 2018-12-10 2018-12-10 液体クロマトグラフ質量分析装置 Active JP6964065B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2018230775A JP6964065B2 (ja) 2018-12-10 2018-12-10 液体クロマトグラフ質量分析装置
US17/296,317 US11860142B2 (en) 2018-12-10 2019-10-25 Liquid chromatograph mass spectrometer
EP19897194.7A EP3896440B1 (en) 2018-12-10 2019-10-25 Liquid chromatograph mass spectrometer
PCT/JP2019/042053 WO2020121660A1 (ja) 2018-12-10 2019-10-25 液体クロマトグラフ質量分析装置
CN201980077153.7A CN114127551B (zh) 2018-12-10 2019-10-25 液相色谱质谱分析装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018230775A JP6964065B2 (ja) 2018-12-10 2018-12-10 液体クロマトグラフ質量分析装置

Publications (3)

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JP2020094817A JP2020094817A (ja) 2020-06-18
JP2020094817A5 JP2020094817A5 (https=) 2021-05-13
JP6964065B2 true JP6964065B2 (ja) 2021-11-10

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US (1) US11860142B2 (https=)
EP (1) EP3896440B1 (https=)
JP (1) JP6964065B2 (https=)
CN (1) CN114127551B (https=)
WO (1) WO2020121660A1 (https=)

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US12078620B2 (en) * 2019-02-22 2024-09-03 Hitachi High-Tech Corporation Analysis apparatus
EP3786634B1 (en) * 2019-08-27 2025-08-06 Roche Diagnostics GmbH Techniques for checking state of analyzers
US20210382021A1 (en) * 2020-06-09 2021-12-09 Waters Technologies Corporation Systems and methods for two-dimensional liquid chromatography using size exclusion chromatography as a first dimension
US12163934B2 (en) * 2020-06-22 2024-12-10 Waters Technologies Corporation Parallel insulated chromatography columns
ES3015159T3 (en) * 2020-10-28 2025-04-29 Hoffmann La Roche Liquid chromatography - stream equivalence by single stream calibration
US20230417781A1 (en) * 2020-12-11 2023-12-28 Hitachi High-Tech Corporation Method of controlling automatic analyzer
JP7569389B2 (ja) * 2020-12-24 2024-10-17 株式会社日立ハイテク 液体クロマトグラフの制御方法および液体クロマトグラフ
EP4291888A1 (en) * 2021-02-12 2023-12-20 Roche Diagnostics GmbH Column device
US12546757B2 (en) 2021-05-13 2026-02-10 Hitachi High-Tech Corporation Method for adjusting pressure sensor and liquid chromatography analyzer
JP7695130B2 (ja) * 2021-07-12 2025-06-18 株式会社日立ハイテク 質量分析システム、処理装置及び異常検出方法
WO2024218866A1 (ja) * 2023-04-18 2024-10-24 株式会社島津製作所 分析装置
CN117571897B (zh) * 2023-11-15 2024-04-30 青岛惠安康生物工程有限公司 一种液相色谱-质谱联用仪及切换装置
CN120319652B (zh) * 2025-06-12 2026-04-10 杭州谱育科技发展有限公司 一种用于质谱仪的电喷雾离子源控制方法及装置

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US4391778A (en) * 1981-09-30 1983-07-05 The Ohio State University Method and apparatus for the analysis of materials by chromatography and mass spectrometry
JPH0545350A (ja) * 1991-08-13 1993-02-23 Yamatake Honeywell Co Ltd ガスクロマトグラフの減圧弁調整方法
JPH11326302A (ja) * 1998-05-13 1999-11-26 Shimadzu Corp 液体クロマトグラフ質量分析装置
JP2000249694A (ja) 1999-02-26 2000-09-14 Shimadzu Corp 液体クロマトグラフ分取装置
JP2001153875A (ja) 1999-11-29 2001-06-08 Olympus Optical Co Ltd 自動分析装置
JP3908142B2 (ja) * 2002-10-02 2007-04-25 株式会社日立ハイテクノロジーズ プラズマイオン源質量分析装置
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JP4946647B2 (ja) * 2007-06-14 2012-06-06 株式会社島津製作所 試料前処理装置及び液体クロマトグラフ装置
JP5286134B2 (ja) 2009-03-31 2013-09-11 株式会社日立ハイテクノロジーズ 検体検査システムとその装置管理サーバの運用方法
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JP2012145513A (ja) * 2011-01-14 2012-08-02 Hitachi High-Technologies Corp 分析装置
JP5545494B2 (ja) 2011-04-05 2014-07-09 横河電機株式会社 クロマトグラフ
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WO2017163413A1 (ja) * 2016-03-25 2017-09-28 科健化学株式会社 中空カラム液体クロマトグラフィーシステム及び該システムを用いた物質の分離
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Publication number Publication date
WO2020121660A1 (ja) 2020-06-18
CN114127551A (zh) 2022-03-01
US20220050091A1 (en) 2022-02-17
CN114127551B (zh) 2024-12-31
EP3896440A4 (en) 2022-08-17
EP3896440B1 (en) 2024-12-11
US11860142B2 (en) 2024-01-02
JP2020094817A (ja) 2020-06-18
EP3896440A1 (en) 2021-10-20

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