CN114127551B - 液相色谱质谱分析装置 - Google Patents

液相色谱质谱分析装置 Download PDF

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Publication number
CN114127551B
CN114127551B CN201980077153.7A CN201980077153A CN114127551B CN 114127551 B CN114127551 B CN 114127551B CN 201980077153 A CN201980077153 A CN 201980077153A CN 114127551 B CN114127551 B CN 114127551B
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flow path
liquid
mass spectrometry
valve
control unit
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CN114127551A (zh
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杉山益之
桥本雄一郎
长谷川英树
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201980077153.7A 2018-12-10 2019-10-25 液相色谱质谱分析装置 Active CN114127551B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-230775 2018-12-10
JP2018230775A JP6964065B2 (ja) 2018-12-10 2018-12-10 液体クロマトグラフ質量分析装置
PCT/JP2019/042053 WO2020121660A1 (ja) 2018-12-10 2019-10-25 液体クロマトグラフ質量分析装置

Publications (2)

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CN114127551A CN114127551A (zh) 2022-03-01
CN114127551B true CN114127551B (zh) 2024-12-31

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US (1) US11860142B2 (https=)
EP (1) EP3896440B1 (https=)
JP (1) JP6964065B2 (https=)
CN (1) CN114127551B (https=)
WO (1) WO2020121660A1 (https=)

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US20210382021A1 (en) * 2020-06-09 2021-12-09 Waters Technologies Corporation Systems and methods for two-dimensional liquid chromatography using size exclusion chromatography as a first dimension
US12163934B2 (en) * 2020-06-22 2024-12-10 Waters Technologies Corporation Parallel insulated chromatography columns
ES3015159T3 (en) * 2020-10-28 2025-04-29 Hoffmann La Roche Liquid chromatography - stream equivalence by single stream calibration
US20230417781A1 (en) * 2020-12-11 2023-12-28 Hitachi High-Tech Corporation Method of controlling automatic analyzer
JP7569389B2 (ja) * 2020-12-24 2024-10-17 株式会社日立ハイテク 液体クロマトグラフの制御方法および液体クロマトグラフ
EP4291888A1 (en) * 2021-02-12 2023-12-20 Roche Diagnostics GmbH Column device
US12546757B2 (en) 2021-05-13 2026-02-10 Hitachi High-Tech Corporation Method for adjusting pressure sensor and liquid chromatography analyzer
JP7695130B2 (ja) * 2021-07-12 2025-06-18 株式会社日立ハイテク 質量分析システム、処理装置及び異常検出方法
WO2024218866A1 (ja) * 2023-04-18 2024-10-24 株式会社島津製作所 分析装置
CN117571897B (zh) * 2023-11-15 2024-04-30 青岛惠安康生物工程有限公司 一种液相色谱-质谱联用仪及切换装置
CN120319652B (zh) * 2025-06-12 2026-04-10 杭州谱育科技发展有限公司 一种用于质谱仪的电喷雾离子源控制方法及装置

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JP2008209334A (ja) * 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 液体クロマトグラフィ装置
WO2017103180A1 (en) * 2015-12-18 2017-06-22 F. Hoffmann-La Roche Ag Automated clinical diagnostic system and method
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JP2008209334A (ja) * 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 液体クロマトグラフィ装置
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Also Published As

Publication number Publication date
WO2020121660A1 (ja) 2020-06-18
CN114127551A (zh) 2022-03-01
US20220050091A1 (en) 2022-02-17
EP3896440A4 (en) 2022-08-17
EP3896440B1 (en) 2024-12-11
US11860142B2 (en) 2024-01-02
JP2020094817A (ja) 2020-06-18
JP6964065B2 (ja) 2021-11-10
EP3896440A1 (en) 2021-10-20

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