JP6915987B2 - マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法 - Google Patents

マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法 Download PDF

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JP6915987B2
JP6915987B2 JP2016516911A JP2016516911A JP6915987B2 JP 6915987 B2 JP6915987 B2 JP 6915987B2 JP 2016516911 A JP2016516911 A JP 2016516911A JP 2016516911 A JP2016516911 A JP 2016516911A JP 6915987 B2 JP6915987 B2 JP 6915987B2
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antibody
amino acid
acid sequence
sequence
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JP2016538240A (ja
JP2016538240A5 (enExample
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ジェイムズ ムーア スティーブン
ジェイムズ ムーア スティーブン
ティー ルー グエン マーガレット
ティー ルー グエン マーガレット
アール．ホステッター ダニエル
アール．ホステッター ダニエル
バジルジェバ オルガ
バジルジェバ オルガ
グレース フランデス ジャンヌ
グレース フランデス ジャンヌ
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シトムクス セラピューティクス，インコーポレイティド
シトムクス セラピューティクス，インコーポレイティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016516911A 2013-09-25 2014-09-25 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法 Active JP6915987B2 (ja)

Applications Claiming Priority (5)

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US201361882377P 2013-09-25 2013-09-25
US61/882,377 2013-09-25
US201461971332P 2014-03-27 2014-03-27
US61/971,332 2014-03-27
PCT/US2014/057523 WO2015048329A2 (en) 2013-09-25 2014-09-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

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JP2016538240A JP2016538240A (ja) 2016-12-08
JP2016538240A5 JP2016538240A5 (enExample) 2017-11-09
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JP2019173550A Pending JP2020015749A (ja) 2013-09-25 2019-09-24 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法
JP2021080015A Withdrawn JP2021138707A (ja) 2013-09-25 2021-05-10 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法
JP2023122426A Pending JP2023159099A (ja) 2013-09-25 2023-07-27 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法
JP2024186751A Active JP7806174B2 (ja) 2013-09-25 2024-10-23 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法

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JP2021080015A Withdrawn JP2021138707A (ja) 2013-09-25 2021-05-10 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法
JP2023122426A Pending JP2023159099A (ja) 2013-09-25 2023-07-27 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法
JP2024186751A Active JP7806174B2 (ja) 2013-09-25 2024-10-23 マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法

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US (4) US20150087810A1 (enExample)
EP (1) EP3049111A2 (enExample)
JP (5) JP6915987B2 (enExample)
KR (3) KR102488220B1 (enExample)
CN (3) CN118165076A (enExample)
AU (4) AU2014324884B2 (enExample)
CA (2) CA2925106C (enExample)
IL (3) IL322893A (enExample)
MX (2) MX379106B (enExample)
NZ (2) NZ718283A (enExample)
RU (1) RU2715232C2 (enExample)
WO (1) WO2015048329A2 (enExample)

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