AU2014324884B2 - Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof - Google Patents

Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof Download PDF

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Publication number
AU2014324884B2
AU2014324884B2 AU2014324884A AU2014324884A AU2014324884B2 AU 2014324884 B2 AU2014324884 B2 AU 2014324884B2 AU 2014324884 A AU2014324884 A AU 2014324884A AU 2014324884 A AU2014324884 A AU 2014324884A AU 2014324884 B2 AU2014324884 B2 AU 2014324884B2
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Australia
Prior art keywords
seq
amino acid
acid sequence
sequence
activatable antibody
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AU2014324884A1 (en
Inventor
Jeanne Grace Flandez
Daniel R. Hostetter
Stephen James Moore
Margaret Thy Luu Nguyen
Olga Vasiljeva
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Cytomx Therapeutics Inc
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Cytomx Therapeutics Inc
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Priority to AU2020203910A priority Critical patent/AU2020203910B2/en
Priority to AU2023254931A priority patent/AU2023254931A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2014324884A 2013-09-25 2014-09-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof Active AU2014324884B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020203910A AU2020203910B2 (en) 2013-09-25 2020-06-12 Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
AU2023254931A AU2023254931A1 (en) 2013-09-25 2023-10-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361882377P 2013-09-25 2013-09-25
US61/882,377 2013-09-25
US201461971332P 2014-03-27 2014-03-27
US61/971,332 2014-03-27
PCT/US2014/057523 WO2015048329A2 (en) 2013-09-25 2014-09-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203910A Division AU2020203910B2 (en) 2013-09-25 2020-06-12 Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof

Publications (2)

Publication Number Publication Date
AU2014324884A1 AU2014324884A1 (en) 2016-04-21
AU2014324884B2 true AU2014324884B2 (en) 2020-03-26

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Application Number Title Priority Date Filing Date
AU2014324884A Active AU2014324884B2 (en) 2013-09-25 2014-09-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
AU2020203910A Active AU2020203910B2 (en) 2013-09-25 2020-06-12 Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
AU2023254931A Pending AU2023254931A1 (en) 2013-09-25 2023-10-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

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AU2020203910A Active AU2020203910B2 (en) 2013-09-25 2020-06-12 Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
AU2023254931A Pending AU2023254931A1 (en) 2013-09-25 2023-10-25 Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof

Country Status (12)

Country Link
US (4) US20150087810A1 (enExample)
EP (1) EP3049111A2 (enExample)
JP (5) JP6915987B2 (enExample)
KR (3) KR102790260B1 (enExample)
CN (3) CN118146306A (enExample)
AU (3) AU2014324884B2 (enExample)
CA (2) CA3214529A1 (enExample)
IL (3) IL291329B1 (enExample)
MX (2) MX379106B (enExample)
NZ (2) NZ718283A (enExample)
RU (1) RU2715232C2 (enExample)
WO (1) WO2015048329A2 (enExample)

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