MX2021000416A - Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos. - Google Patents
Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos.Info
- Publication number
- MX2021000416A MX2021000416A MX2021000416A MX2021000416A MX2021000416A MX 2021000416 A MX2021000416 A MX 2021000416A MX 2021000416 A MX2021000416 A MX 2021000416A MX 2021000416 A MX2021000416 A MX 2021000416A MX 2021000416 A MX2021000416 A MX 2021000416A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- matrix metalloproteinase
- cleavable moieties
- substrate
- cleavable moiety
- Prior art date
Links
- 239000000758 substrate Substances 0.000 title abstract 4
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención está relacionada en general a polipéptidos que incluyen una porción escindible que es un substrato para al menos una metaloproteasa de matriz (MMP), a anticuerpos activables y a otras moléculas más grandes que incluyen la porción escindible que es un substrato para al menos una MMP proteasa, y a métodos para preparar y usar estos polipéptidos que incluyen una porción escindible que es un substrato para al menos una MMP proteasa en una variedad de indicaciones terapéuticas, de diagnostico y profilácticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361882377P | 2013-09-25 | 2013-09-25 | |
US201461971332P | 2014-03-27 | 2014-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021000416A true MX2021000416A (es) | 2021-03-25 |
Family
ID=51691175
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016003957A MX2016003957A (es) | 2013-09-25 | 2014-09-25 | Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos. |
MX2021000416A MX2021000416A (es) | 2013-09-25 | 2016-03-28 | Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016003957A MX2016003957A (es) | 2013-09-25 | 2014-09-25 | Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos. |
Country Status (12)
Country | Link |
---|---|
US (4) | US20150087810A1 (es) |
EP (1) | EP3049111A2 (es) |
JP (4) | JP6915987B2 (es) |
KR (2) | KR20230011497A (es) |
CN (3) | CN118165076A (es) |
AU (3) | AU2014324884B2 (es) |
CA (2) | CA2925106C (es) |
IL (2) | IL244744B (es) |
MX (2) | MX2016003957A (es) |
NZ (2) | NZ756892A (es) |
RU (2) | RU2020106752A (es) |
WO (1) | WO2015048329A2 (es) |
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2014
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- 2014-09-25 KR KR1020237000930A patent/KR20230011497A/ko not_active Application Discontinuation
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