JP6898915B2 - 生物を用いる長鎖ジカルボン酸の高レベルの生産 - Google Patents

生物を用いる長鎖ジカルボン酸の高レベルの生産 Download PDF

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JP6898915B2
JP6898915B2 JP2018502751A JP2018502751A JP6898915B2 JP 6898915 B2 JP6898915 B2 JP 6898915B2 JP 2018502751 A JP2018502751 A JP 2018502751A JP 2018502751 A JP2018502751 A JP 2018502751A JP 6898915 B2 JP6898915 B2 JP 6898915B2
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enzyme
lcda
seq
long
cells
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JP2018519843A (ja
JP2018519843A5 (enExample
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クイン・クン・ヂゥ
シャオチュン・ファン
ソン−ピョ・ホン
デスピーナ・ボージオーコー
ドンミン・シェー
ヒマンシュー・エイチ・ダーマンカー
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2018502751A 2015-07-22 2016-07-20 生物を用いる長鎖ジカルボン酸の高レベルの生産 Expired - Fee Related JP6898915B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562195338P 2015-07-22 2015-07-22
US201562195340P 2015-07-22 2015-07-22
US62/195,338 2015-07-22
US62/195,340 2015-07-22
PCT/US2016/043133 WO2017015368A1 (en) 2015-07-22 2016-07-20 High level production of long-chain dicarboxylic acids with microbes

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JP2018519843A JP2018519843A (ja) 2018-07-26
JP2018519843A5 JP2018519843A5 (enExample) 2019-08-22
JP6898915B2 true JP6898915B2 (ja) 2021-07-07

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JP2018502751A Expired - Fee Related JP6898915B2 (ja) 2015-07-22 2016-07-20 生物を用いる長鎖ジカルボン酸の高レベルの生産

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US (1) US10626424B2 (enExample)
EP (1) EP3325607A1 (enExample)
JP (1) JP6898915B2 (enExample)
CN (1) CN108138121B (enExample)
MY (1) MY191314A (enExample)
WO (1) WO2017015368A1 (enExample)

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CN107400675B (zh) * 2017-08-29 2021-01-26 海南省农业科学院植物保护研究所 一种抗瓜类枯萎病活性产物基因的克隆与序列分析方法
CN110684676B (zh) * 2018-07-06 2023-08-08 上海凯赛生物技术股份有限公司 一种低含量羟基酸杂质的长链二元酸及其生产方法
US11136596B2 (en) * 2018-07-06 2021-10-05 Cibt America Inc. Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof
CN111394400B (zh) * 2019-01-03 2022-08-19 上海凯赛生物技术股份有限公司 Sct1基因在长链二元酸生产中的应用
CN111394399B (zh) * 2019-01-03 2022-06-28 上海凯赛生物技术股份有限公司 一种降低长链二元酸中酰基甘油酯杂质含量的方法
CN112301066B (zh) * 2019-07-31 2022-08-02 上海凯赛生物技术股份有限公司 发酵生产长链二元酸的菌株及其制备方法与应用
KR102212882B1 (ko) * 2019-09-25 2021-02-08 한국원자력연구원 지방산 생산능이 증가된 클라미도모나스 속 미세조류 및 클라미도모나스 속 미세조류의 지방산 생산능을 증가시키는 방법
KR102343479B1 (ko) * 2020-06-23 2021-12-27 한국생명공학연구원 스핑고지질 및 스핑고이드 염기의 생산성이 향상된 피키아 시페라이 변이 균주 및 이의 제조방법
WO2022235655A1 (en) 2021-05-04 2022-11-10 Nutrition & Biosciences USA 4, Inc. Compositions comprising insoluble alpha-glucan
CN115710584A (zh) * 2021-08-18 2023-02-24 上海凯赛生物技术股份有限公司 超氧化物歧化酶在制备lcda中的应用及过表达其的基因工程菌
CN113943760B (zh) * 2021-12-02 2023-09-12 王婷 维斯假丝酵母发酵生产长链二元酸的方法、产品与菌种
EP4463519A1 (en) 2022-01-12 2024-11-20 Nutrition & Biosciences USA 4, Inc. Coating compositions comprising rubber and insoluble alpha-glucan
CN117257695B (zh) * 2022-12-11 2025-10-17 麦吉丽生物科技有限公司 发酵水油双层组合物及其制备方法与应用
CN116656505B (zh) * 2023-04-23 2024-04-16 四川大学 一种高产醇脱氢酶和酰基转移酶菌株及培养方法及应用
WO2025097559A1 (zh) * 2023-11-08 2025-05-15 上海凯赛生物技术股份有限公司 一种长链二元酸及发酵生产长链二元酸的方法
CN119954637A (zh) * 2023-11-08 2025-05-09 上海凯赛生物技术股份有限公司 生产长链二元酸的方法及长链二元酸
WO2025207802A1 (en) 2024-03-27 2025-10-02 Nutrition & Biosciences USA 4, Inc. Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof
CN119913054A (zh) * 2025-01-15 2025-05-02 中国科学院天津工业生物技术研究所 一种对香豆酸或对香豆酸衍生物生产水平提高的微生物及其构建方法和应用

Family Cites Families (17)

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US4880741A (en) 1983-10-06 1989-11-14 Pfizer Inc. Process for transformation of Yarrowia lipolytica
US5071764A (en) 1983-10-06 1991-12-10 Pfizer Inc. Process for integrative transformation of yarrowia lipolytica
US20040146999A1 (en) 1997-07-21 2004-07-29 E.I. Du Pont De Nemours And Company Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
FR2879215B1 (fr) * 2004-12-15 2010-08-20 Inst Francais Du Petrole Production d'acides dicarboxyliques par des souches mutantes ameliorees de yarrowia lipolytica
US8846374B2 (en) 2006-12-12 2014-09-30 E I Du Pont De Nemours And Company Carotenoid production in a recombinant oleaginous yeast
US8323935B2 (en) 2007-10-03 2012-12-04 E I Du Pont De Nemours And Company Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production
WO2012071439A1 (en) 2010-11-22 2012-05-31 The Regents Of The University Of California Host cells and methods for producing diacid compounds
US8729298B2 (en) 2011-03-28 2014-05-20 Cathay Industrial Biotech Ltd. Method for separation and purification of long-chain diacids
MY184871A (en) * 2011-07-06 2021-04-28 Radici Chimica S P A Biological methods for preparing a fatty dicarboxylic acid
EP2785835A2 (en) * 2011-11-28 2014-10-08 Solazyme, Inc. Genetically engineered microbial strains including prototheca lipid pathway genes
US8916365B2 (en) * 2012-04-03 2014-12-23 E I Du Pont De Nemours And Company Expression of cytosolic malic enzyme in transgenic Yarrowia to increase lipid production
US9909153B2 (en) * 2012-11-09 2018-03-06 Calysta, Inc. Compositions and methods for biological production of fatty acid derivatives
JP2016501040A (ja) * 2012-12-19 2016-01-18 ヴェルデザイン，インコーポレーテッド 脂肪族ジカルボン酸を調製するための生物学的方法
CA2892516A1 (en) 2012-12-21 2014-06-26 E. I. Du Pont De Nemours And Company Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells
EP2843043A1 (en) * 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids

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US20190144897A1 (en) 2019-05-16
MY191314A (en) 2022-06-15
WO2017015368A1 (en) 2017-01-26
CN108138121A (zh) 2018-06-08
US10626424B2 (en) 2020-04-21
CN108138121B (zh) 2022-04-19
EP3325607A1 (en) 2018-05-30
JP2018519843A (ja) 2018-07-26

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