CN108138121B - 用微生物高水平生产长链二羧酸 - Google Patents

用微生物高水平生产长链二羧酸 Download PDF

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Publication number
CN108138121B
CN108138121B CN201680055065.3A CN201680055065A CN108138121B CN 108138121 B CN108138121 B CN 108138121B CN 201680055065 A CN201680055065 A CN 201680055065A CN 108138121 B CN108138121 B CN 108138121B
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lcda
enzyme
seq
cells
cell
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CN108138121A (zh
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Q.Q.朱
X.范
S-P.洪
D.博吉奥考
D.谢
H.H.德哈曼卡
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201680055065.3A 2015-07-22 2016-07-20 用微生物高水平生产长链二羧酸 Expired - Fee Related CN108138121B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562195338P 2015-07-22 2015-07-22
US201562195340P 2015-07-22 2015-07-22
US62/195340 2015-07-22
US62/195338 2015-07-22
PCT/US2016/043133 WO2017015368A1 (en) 2015-07-22 2016-07-20 High level production of long-chain dicarboxylic acids with microbes

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CN108138121A CN108138121A (zh) 2018-06-08
CN108138121B true CN108138121B (zh) 2022-04-19

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US (1) US10626424B2 (enExample)
EP (1) EP3325607A1 (enExample)
JP (1) JP6898915B2 (enExample)
CN (1) CN108138121B (enExample)
MY (1) MY191314A (enExample)
WO (1) WO2017015368A1 (enExample)

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CN110684676B (zh) * 2018-07-06 2023-08-08 上海凯赛生物技术股份有限公司 一种低含量羟基酸杂质的长链二元酸及其生产方法
US11136596B2 (en) * 2018-07-06 2021-10-05 Cibt America Inc. Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof
CN111394400B (zh) * 2019-01-03 2022-08-19 上海凯赛生物技术股份有限公司 Sct1基因在长链二元酸生产中的应用
CN111394399B (zh) * 2019-01-03 2022-06-28 上海凯赛生物技术股份有限公司 一种降低长链二元酸中酰基甘油酯杂质含量的方法
CN112301066B (zh) * 2019-07-31 2022-08-02 上海凯赛生物技术股份有限公司 发酵生产长链二元酸的菌株及其制备方法与应用
KR102212882B1 (ko) * 2019-09-25 2021-02-08 한국원자력연구원 지방산 생산능이 증가된 클라미도모나스 속 미세조류 및 클라미도모나스 속 미세조류의 지방산 생산능을 증가시키는 방법
KR102343479B1 (ko) * 2020-06-23 2021-12-27 한국생명공학연구원 스핑고지질 및 스핑고이드 염기의 생산성이 향상된 피키아 시페라이 변이 균주 및 이의 제조방법
WO2022235655A1 (en) 2021-05-04 2022-11-10 Nutrition & Biosciences USA 4, Inc. Compositions comprising insoluble alpha-glucan
CN115710584A (zh) * 2021-08-18 2023-02-24 上海凯赛生物技术股份有限公司 超氧化物歧化酶在制备lcda中的应用及过表达其的基因工程菌
CN113943760B (zh) * 2021-12-02 2023-09-12 王婷 维斯假丝酵母发酵生产长链二元酸的方法、产品与菌种
EP4463519A1 (en) 2022-01-12 2024-11-20 Nutrition & Biosciences USA 4, Inc. Coating compositions comprising rubber and insoluble alpha-glucan
CN117257695B (zh) * 2022-12-11 2025-10-17 麦吉丽生物科技有限公司 发酵水油双层组合物及其制备方法与应用
CN116656505B (zh) * 2023-04-23 2024-04-16 四川大学 一种高产醇脱氢酶和酰基转移酶菌株及培养方法及应用
WO2025097559A1 (zh) * 2023-11-08 2025-05-15 上海凯赛生物技术股份有限公司 一种长链二元酸及发酵生产长链二元酸的方法
CN119954637A (zh) * 2023-11-08 2025-05-09 上海凯赛生物技术股份有限公司 生产长链二元酸的方法及长链二元酸
WO2025207802A1 (en) 2024-03-27 2025-10-02 Nutrition & Biosciences USA 4, Inc. Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof
CN119913054A (zh) * 2025-01-15 2025-05-02 中国科学院天津工业生物技术研究所 一种对香豆酸或对香豆酸衍生物生产水平提高的微生物及其构建方法和应用

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CN104321424A (zh) * 2012-04-03 2015-01-28 纳幕尔杜邦公司 在转基因耶氏酵母属中表达胞浆苹果酸酶以提高脂质产量
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US20190144897A1 (en) 2019-05-16
MY191314A (en) 2022-06-15
WO2017015368A1 (en) 2017-01-26
CN108138121A (zh) 2018-06-08
US10626424B2 (en) 2020-04-21
EP3325607A1 (en) 2018-05-30
JP6898915B2 (ja) 2021-07-07
JP2018519843A (ja) 2018-07-26

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