JP2018519843A5 - - Google Patents
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- Publication number
- JP2018519843A5 JP2018519843A5 JP2018502751A JP2018502751A JP2018519843A5 JP 2018519843 A5 JP2018519843 A5 JP 2018519843A5 JP 2018502751 A JP2018502751 A JP 2018502751A JP 2018502751 A JP2018502751 A JP 2018502751A JP 2018519843 A5 JP2018519843 A5 JP 2018519843A5
- Authority
- JP
- Japan
- Prior art keywords
- lcda
- long chain
- microbial cell
- producing
- recombinant microbial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000813 microbial effect Effects 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- 150000004668 long chain fatty acids Chemical class 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195338P | 2015-07-22 | 2015-07-22 | |
| US201562195340P | 2015-07-22 | 2015-07-22 | |
| US62/195,338 | 2015-07-22 | ||
| US62/195,340 | 2015-07-22 | ||
| PCT/US2016/043133 WO2017015368A1 (en) | 2015-07-22 | 2016-07-20 | High level production of long-chain dicarboxylic acids with microbes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519843A JP2018519843A (ja) | 2018-07-26 |
| JP2018519843A5 true JP2018519843A5 (enExample) | 2019-08-22 |
| JP6898915B2 JP6898915B2 (ja) | 2021-07-07 |
Family
ID=57834583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502751A Expired - Fee Related JP6898915B2 (ja) | 2015-07-22 | 2016-07-20 | 生物を用いる長鎖ジカルボン酸の高レベルの生産 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10626424B2 (enExample) |
| EP (1) | EP3325607A1 (enExample) |
| JP (1) | JP6898915B2 (enExample) |
| CN (1) | CN108138121B (enExample) |
| MY (1) | MY191314A (enExample) |
| WO (1) | WO2017015368A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107400675B (zh) * | 2017-08-29 | 2021-01-26 | 海南省农业科学院植物保护研究所 | 一种抗瓜类枯萎病活性产物基因的克隆与序列分析方法 |
| CN110684676B (zh) * | 2018-07-06 | 2023-08-08 | 上海凯赛生物技术股份有限公司 | 一种低含量羟基酸杂质的长链二元酸及其生产方法 |
| US11136596B2 (en) * | 2018-07-06 | 2021-10-05 | Cibt America Inc. | Long-chain dibasic acid with low content of hydroxyl acid impurity and production method thereof |
| CN111394400B (zh) * | 2019-01-03 | 2022-08-19 | 上海凯赛生物技术股份有限公司 | Sct1基因在长链二元酸生产中的应用 |
| CN111394399B (zh) * | 2019-01-03 | 2022-06-28 | 上海凯赛生物技术股份有限公司 | 一种降低长链二元酸中酰基甘油酯杂质含量的方法 |
| CN112301066B (zh) * | 2019-07-31 | 2022-08-02 | 上海凯赛生物技术股份有限公司 | 发酵生产长链二元酸的菌株及其制备方法与应用 |
| KR102212882B1 (ko) * | 2019-09-25 | 2021-02-08 | 한국원자력연구원 | 지방산 생산능이 증가된 클라미도모나스 속 미세조류 및 클라미도모나스 속 미세조류의 지방산 생산능을 증가시키는 방법 |
| KR102343479B1 (ko) * | 2020-06-23 | 2021-12-27 | 한국생명공학연구원 | 스핑고지질 및 스핑고이드 염기의 생산성이 향상된 피키아 시페라이 변이 균주 및 이의 제조방법 |
| WO2022235655A1 (en) | 2021-05-04 | 2022-11-10 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising insoluble alpha-glucan |
| CN115710584A (zh) * | 2021-08-18 | 2023-02-24 | 上海凯赛生物技术股份有限公司 | 超氧化物歧化酶在制备lcda中的应用及过表达其的基因工程菌 |
| CN113943760B (zh) * | 2021-12-02 | 2023-09-12 | 王婷 | 维斯假丝酵母发酵生产长链二元酸的方法、产品与菌种 |
| EP4463519A1 (en) | 2022-01-12 | 2024-11-20 | Nutrition & Biosciences USA 4, Inc. | Coating compositions comprising rubber and insoluble alpha-glucan |
| CN117257695B (zh) * | 2022-12-11 | 2025-10-17 | 麦吉丽生物科技有限公司 | 发酵水油双层组合物及其制备方法与应用 |
| CN116656505B (zh) * | 2023-04-23 | 2024-04-16 | 四川大学 | 一种高产醇脱氢酶和酰基转移酶菌株及培养方法及应用 |
| WO2025097559A1 (zh) * | 2023-11-08 | 2025-05-15 | 上海凯赛生物技术股份有限公司 | 一种长链二元酸及发酵生产长链二元酸的方法 |
| CN119954637A (zh) * | 2023-11-08 | 2025-05-09 | 上海凯赛生物技术股份有限公司 | 生产长链二元酸的方法及长链二元酸 |
| WO2025207802A1 (en) | 2024-03-27 | 2025-10-02 | Nutrition & Biosciences USA 4, Inc. | Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof |
| CN119913054A (zh) * | 2025-01-15 | 2025-05-02 | 中国科学院天津工业生物技术研究所 | 一种对香豆酸或对香豆酸衍生物生产水平提高的微生物及其构建方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880741A (en) | 1983-10-06 | 1989-11-14 | Pfizer Inc. | Process for transformation of Yarrowia lipolytica |
| US5071764A (en) | 1983-10-06 | 1991-12-10 | Pfizer Inc. | Process for integrative transformation of yarrowia lipolytica |
| US20040146999A1 (en) | 1997-07-21 | 2004-07-29 | E.I. Du Pont De Nemours And Company | Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| FR2879215B1 (fr) * | 2004-12-15 | 2010-08-20 | Inst Francais Du Petrole | Production d'acides dicarboxyliques par des souches mutantes ameliorees de yarrowia lipolytica |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US8323935B2 (en) | 2007-10-03 | 2012-12-04 | E I Du Pont De Nemours And Company | Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production |
| WO2012071439A1 (en) | 2010-11-22 | 2012-05-31 | The Regents Of The University Of California | Host cells and methods for producing diacid compounds |
| US8729298B2 (en) | 2011-03-28 | 2014-05-20 | Cathay Industrial Biotech Ltd. | Method for separation and purification of long-chain diacids |
| MY184871A (en) * | 2011-07-06 | 2021-04-28 | Radici Chimica S P A | Biological methods for preparing a fatty dicarboxylic acid |
| EP2785835A2 (en) * | 2011-11-28 | 2014-10-08 | Solazyme, Inc. | Genetically engineered microbial strains including prototheca lipid pathway genes |
| US8916365B2 (en) * | 2012-04-03 | 2014-12-23 | E I Du Pont De Nemours And Company | Expression of cytosolic malic enzyme in transgenic Yarrowia to increase lipid production |
| US9909153B2 (en) * | 2012-11-09 | 2018-03-06 | Calysta, Inc. | Compositions and methods for biological production of fatty acid derivatives |
| JP2016501040A (ja) * | 2012-12-19 | 2016-01-18 | ヴェルデザイン，インコーポレーテッド | 脂肪族ジカルボン酸を調製するための生物学的方法 |
| CA2892516A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| EP2843043A1 (en) * | 2013-08-27 | 2015-03-04 | Evonik Industries AG | A method for producing acyl amino acids |
-
2016
- 2016-07-20 JP JP2018502751A patent/JP6898915B2/ja not_active Expired - Fee Related
- 2016-07-20 MY MYPI2018700157A patent/MY191314A/en unknown
- 2016-07-20 EP EP16747664.7A patent/EP3325607A1/en not_active Withdrawn
- 2016-07-20 WO PCT/US2016/043133 patent/WO2017015368A1/en not_active Ceased
- 2016-07-20 US US15/746,094 patent/US10626424B2/en not_active Expired - Fee Related
- 2016-07-20 CN CN201680055065.3A patent/CN108138121B/zh not_active Expired - Fee Related
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