JP6885869B2 - がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 - Google Patents

がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 Download PDF

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JP6885869B2
JP6885869B2 JP2017545299A JP2017545299A JP6885869B2 JP 6885869 B2 JP6885869 B2 JP 6885869B2 JP 2017545299 A JP2017545299 A JP 2017545299A JP 2017545299 A JP2017545299 A JP 2017545299A JP 6885869 B2 JP6885869 B2 JP 6885869B2
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cancer
antibody
patients
treatment
avelumab
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JP2018508512A (ja
JP2018508512A5 (OSRAM
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クイラーロット，ジャン−マリー
ボン ハイデブレック，アンジャ
ボン ハイデブレック，アンジャ
ユアン，グオジュン
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017545299A 2015-02-26 2016-02-23 がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 Active JP6885869B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562121025P 2015-02-26 2015-02-26
US62/121,025 2015-02-26
US201562133721P 2015-03-16 2015-03-16
US62/133,721 2015-03-16
US201562160291P 2015-05-12 2015-05-12
US62/160,291 2015-05-12
US201562215394P 2015-09-08 2015-09-08
US62/215,394 2015-09-08
US201562254424P 2015-11-12 2015-11-12
US62/254,424 2015-11-12
PCT/US2016/019120 WO2016137985A1 (en) 2015-02-26 2016-02-23 Pd-1 / pd-l1 inhibitors for the treatment of cancer

Related Child Applications (1)

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JP2020050850A Division JP7116113B2 (ja) 2015-02-26 2020-03-23 がんを治療するためのｐｄ－１／ｐｄ－ｌ１阻害剤

Publications (3)

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JP2018508512A JP2018508512A (ja) 2018-03-29
JP2018508512A5 JP2018508512A5 (OSRAM) 2019-03-14
JP6885869B2 true JP6885869B2 (ja) 2021-06-16

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JP2017545299A Active JP6885869B2 (ja) 2015-02-26 2016-02-23 がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤
JP2020050850A Active JP7116113B2 (ja) 2015-02-26 2020-03-23 がんを治療するためのｐｄ－１／ｐｄ－ｌ１阻害剤
JP2021107909A Pending JP2021178822A (ja) 2015-02-26 2021-06-29 がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤

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JP2021107909A Pending JP2021178822A (ja) 2015-02-26 2021-06-29 がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤

Country Status (15)

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US (2) US10800846B2 (OSRAM)
EP (2) EP4279087A3 (OSRAM)
JP (3) JP6885869B2 (OSRAM)
KR (1) KR20170132171A (OSRAM)
CN (2) CN107405401B (OSRAM)
AU (3) AU2016222928B2 (OSRAM)
BR (1) BR112017018234A2 (OSRAM)
CA (1) CA2977767C (OSRAM)
IL (2) IL278423B2 (OSRAM)
MX (2) MX393976B (OSRAM)
NZ (1) NZ733854A (OSRAM)
RU (1) RU2714233C2 (OSRAM)
SG (2) SG10201810615VA (OSRAM)
TW (2) TWI748942B (OSRAM)
WO (1) WO2016137985A1 (OSRAM)

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