JP6882172B2 - 神経変性疾患の治療に有用なtdp−43結合性ポリペプチド - Google Patents
神経変性疾患の治療に有用なtdp−43結合性ポリペプチド Download PDFInfo
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- JP6882172B2 JP6882172B2 JP2017529766A JP2017529766A JP6882172B2 JP 6882172 B2 JP6882172 B2 JP 6882172B2 JP 2017529766 A JP2017529766 A JP 2017529766A JP 2017529766 A JP2017529766 A JP 2017529766A JP 6882172 B2 JP6882172 B2 JP 6882172B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
- C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
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- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Biochemistry (AREA)
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- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
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- Plant Pathology (AREA)
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- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088012P | 2014-12-05 | 2014-12-05 | |
| US62/088,012 | 2014-12-05 | ||
| CA2,874,083 | 2014-12-05 | ||
| CA2874083A CA2874083C (en) | 2014-12-05 | 2014-12-05 | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| PCT/CA2015/051280 WO2016086320A1 (en) | 2014-12-05 | 2015-12-07 | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502561A JP2018502561A (ja) | 2018-02-01 |
| JP2018502561A5 JP2018502561A5 (https=) | 2019-01-24 |
| JP6882172B2 true JP6882172B2 (ja) | 2021-06-02 |
Family
ID=56090779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529766A Active JP6882172B2 (ja) | 2014-12-05 | 2015-12-07 | 神経変性疾患の治療に有用なtdp−43結合性ポリペプチド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10202443B2 (https=) |
| EP (1) | EP3227330B1 (https=) |
| JP (1) | JP6882172B2 (https=) |
| AU (2) | AU2015358266A1 (https=) |
| CA (1) | CA2874083C (https=) |
| WO (1) | WO2016086320A1 (https=) |
Families Citing this family (181)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2352763T5 (pl) * | 2008-10-01 | 2023-01-30 | Amgen Research (Munich) Gmbh | Bispecyficzne przeciwciała jednołańcuchowe o specyficzności wobec antygenów docelowych o dużej masie cząsteczkowej |
| ES2656442T3 (es) * | 2011-09-19 | 2018-02-27 | Axon Neuroscience Se | Terapia basada en proteínas y diagnóstico de una patología mediada por tau en la enfermedad de Alzheimer |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| JP6226752B2 (ja) | 2012-02-09 | 2017-11-08 | 中外製薬株式会社 | 抗体のFc領域改変体 |
| WO2014059442A2 (en) * | 2012-10-12 | 2014-04-17 | Arizona Board Agents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Antibody based reagents that specifically recognize toxic oligomeric forms of tau |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| HRP20200384T1 (hr) * | 2013-12-20 | 2020-06-12 | F. Hoffmann - La Roche Ag | Humanizirana anti-tau(ps422) protutijela i načini uporabe |
| EP3327038B1 (en) * | 2013-12-20 | 2020-09-23 | F. Hoffmann-La Roche AG | Bispecific her2 antibodies and methods of use |
| RU2678810C2 (ru) * | 2014-02-02 | 2019-02-01 | Медиммун Лимитед | ХИМЕРНЫЙ БЕЛОК, СОСТАВЛЕННЫЙ ИЗ ДОМЕНА АНТАГОНИСТА NGF И ДОМЕНА АНТАГОНИСТА TNFα |
| KR20230104759A (ko) | 2014-09-30 | 2023-07-10 | 뉴리뮨 홀딩 아게 | 인간-유래의 항-디펩티드 반복체(dpr) 항체 |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| EP4465050A3 (en) | 2015-06-05 | 2025-06-11 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| US11130815B2 (en) | 2015-06-24 | 2021-09-28 | Jcr Pharmaceuticals Co., Ltd. | Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody |
| TWI769982B (zh) * | 2015-06-24 | 2022-07-11 | 日商Jcr製藥股份有限公司 | 通過血腦障壁之抗人類運鐵蛋白受體抗體 |
| CN107810196B (zh) | 2015-06-24 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 人源化的抗-Tau(pS422)抗体和使用方法 |
| KR102770650B1 (ko) | 2015-07-06 | 2025-02-19 | 유씨비 바이오파마 에스알엘 | 타우 결합 항체 |
| CA2991264C (en) | 2015-07-06 | 2023-10-10 | Ucb Biopharma Sprl | Tau-binding antibodies |
| FI3334761T3 (fi) * | 2015-08-13 | 2023-08-14 | Univ New York | Vasta-ainepohjaisia molekyylejä, jotka ovat selektiivisiä Taun {p}Ser404-epitoopille, ja niiden käyttöjä tauopatian diagnosoinnissa ja hoidossa |
| WO2017176835A2 (en) * | 2016-04-06 | 2017-10-12 | Imago Pharmaceuticals, Inc. | Therapeutic antibodies for treatment of neurodegeneration |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| KR20190022632A (ko) | 2016-06-20 | 2019-03-06 | 에프-스타 베타 리미티드 | Lag-3 결합 구성원 |
| CA3030754C (en) * | 2016-07-20 | 2022-04-26 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| WO2018018031A1 (en) * | 2016-07-22 | 2018-01-25 | New York University | Specific murine and humanized monoclonal antibodies detecting pathology associated secondary structure changes in proteins and peptides |
| CN117820467A (zh) * | 2016-12-07 | 2024-04-05 | 基因泰克公司 | 抗tau抗体和使用方法 |
| MA48595A (fr) | 2016-12-07 | 2020-03-18 | Ac Immune Sa | Anticorps anti-tau et leurs méthodes d'utilisation |
| RU2768404C2 (ru) * | 2016-12-23 | 2022-03-24 | Ремд Биотерапьютикс, Инк. | Иммунотерапия с применением антител, связывающих белок 1 программируемой смерти клеток (pd-1) |
| AU2017385274B2 (en) | 2016-12-26 | 2024-02-22 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein including BDNF |
| TWI761413B (zh) | 2016-12-26 | 2022-04-21 | 日商Jcr製藥股份有限公司 | 通過血腦障壁之新穎抗人類運鐵蛋白受體抗體 |
| US12049493B2 (en) * | 2017-01-06 | 2024-07-30 | Abl Bio Inc. | Anti-alpha-synuclein antibodies and uses thereof |
| CN118184777A (zh) * | 2017-01-30 | 2024-06-14 | 亚力兄制药公司 | 单价抗备解素抗体及抗体片段 |
| EP3580241A4 (en) * | 2017-02-10 | 2021-01-06 | The Trustees Of The University Of Pennsylvania | ANTIFACTOR D ANTIBODIES AND USES THEREOF |
| US11578137B2 (en) * | 2017-03-06 | 2023-02-14 | The Trustees Of The University Of Pennsylvania | Anti-C5 antibodies and uses thereof |
| BR112019019595A2 (pt) * | 2017-03-23 | 2020-04-14 | Univ Pennsylvania | anticorpo, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indivíduo e para reduzir a atividade de um sistema complemento de um indivíduo, e, célula |
| EP3601346A1 (en) * | 2017-03-29 | 2020-02-05 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
| CN110691793A (zh) * | 2017-04-26 | 2020-01-14 | 田边三菱制药株式会社 | 黏结蛋白聚糖-1(cd138)结合剂及其用 |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| CA3064785A1 (en) * | 2017-05-30 | 2018-12-06 | The University Of British Columbia | Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto |
| EP3431496A1 (en) * | 2017-07-19 | 2019-01-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anti- isoasp7 amyloid beta antibodies and uses thereof |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| JP7204235B2 (ja) * | 2017-08-02 | 2023-01-16 | ストレスマーク・バイオサイエンシーズ・インコーポレイテッド | 活性型α-シヌクレインに結合する抗体 |
| JP7356727B2 (ja) * | 2017-10-12 | 2023-10-05 | 慶應義塾 | アクアポリン3(aqp3)の細胞外ドメインに特異的に結合する抗aqp3モノクローナル抗体、及びその使用 |
| KR20200106495A (ko) * | 2017-11-29 | 2020-09-14 | 보오드 오브 리젠츠, 더 유니버시티 오브 텍사스 시스템 | 암 치료요법을 위한 조성물 및 방법 |
| AU2018379306A1 (en) * | 2017-12-05 | 2020-06-25 | Mabion Sa | Combination therapy of multiple sclerosis comprising a CD20 ligand |
| WO2019118906A2 (en) * | 2017-12-14 | 2019-06-20 | University Of Florida Research Foundation | Monoclonal antibodies targeting phf1 and at8 epitopes of human tau protein |
| US12071483B1 (en) | 2017-12-14 | 2024-08-27 | Abl Bio Inc. | Bispecific antibody to alpha-synuclein/insulin-like growth factor 1 receptor and use thereof |
| WO2019113711A1 (en) | 2017-12-14 | 2019-06-20 | University Of Ottawa | Exosome packaging and targeted autophagy |
| EP3732201A4 (en) | 2017-12-19 | 2022-04-20 | Surrozen Operating, Inc. | WNT SURROGATES AND THEIR USES |
| CN111699003B (zh) * | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| JP7490565B2 (ja) * | 2017-12-29 | 2024-05-27 | アレクトル エルエルシー | 抗tmem106b抗体及びその使用方法 |
| EP3735422A1 (en) * | 2018-01-05 | 2020-11-11 | AC Immune SA | Misfolded tdp-43 binding molecules |
| EP3746478A4 (en) * | 2018-01-29 | 2022-01-19 | The Regents of The University of California | THERAPIES AND METHODS OF TREATING TLR2-MEDIATED DISEASES AND DISORDERS |
| CN111971301B (zh) | 2018-01-31 | 2025-01-07 | 艾莱克特有限责任公司 | 抗ms4a4a抗体及其使用方法 |
| CN112204050B (zh) | 2018-01-31 | 2025-03-14 | 艾莱克特有限责任公司 | 抗ms4a6a抗体及其使用方法 |
| JP7539834B2 (ja) * | 2018-02-01 | 2024-08-26 | メモリアル スローン ケタリング キャンサー センター | ガレクチン-3に対する抗体及びその使用方法 |
| WO2019161384A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Tau single domain antibodies |
| KR20200130324A (ko) | 2018-02-23 | 2020-11-18 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | Cd83-결합 키메라 항원 수용체 |
| CA3093692A1 (en) | 2018-03-14 | 2019-09-19 | Boehringer Ingelheim International Gmbh | Use of anti-il-36r antibodies for treatment of generalized pustular psoriasis |
| TWI791794B (zh) * | 2018-03-20 | 2023-02-11 | 瑞士商諾華公司 | 藥物組合 |
| AU2018418224B2 (en) | 2018-04-09 | 2025-04-17 | Oricell Therapeutics Co., Ltd. | Anti-PD-L1 antibody and use thereof |
| BR112020020787A2 (pt) * | 2018-04-11 | 2021-02-02 | Tychan Pte. Ltd. | métodos e composições para o tratamento de febre amarela |
| CN112004558A (zh) * | 2018-04-12 | 2020-11-27 | 米迪亚制药有限责任公司 | Lgals3bp抗体-药物-偶联物及其用于癌症的治疗的用途 |
| CA3097999A1 (en) * | 2018-04-24 | 2019-10-31 | Neuracle Science Co., Ltd. | Use of anti-family with sequence similarity 19, member a5 antibodies for the treatment of neuropathic pain |
| KR20210005096A (ko) * | 2018-04-25 | 2021-01-13 | 메디뮨 리미티드 | 인간 항-pd-l1 항체의 제형 |
| BR112020021855A2 (pt) | 2018-04-27 | 2021-02-23 | Biogen Ma Inc. | anticorpo antirrepetição de dipeptídeo (dpr) (poli-ga) derivado de humanos |
| GB201806918D0 (en) * | 2018-04-27 | 2018-06-13 | Enleofen Bio Pte Ltd | Combination treatment for eye fibrosis |
| US11613571B2 (en) * | 2018-05-23 | 2023-03-28 | Glaxosmithkline Intellectual Property Development Limited | Biopharmaceutical compositions comprising antibody variants |
| WO2019225787A1 (ko) * | 2018-05-24 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-b7-h3 항체 및 그 용도 |
| WO2019229296A1 (en) * | 2018-05-29 | 2019-12-05 | Teknologian Tutkimuskeskus Vtt Oy | Anti-thyroid hormone (t4) recombinant antibody or antigen binding fragment |
| EP3802600A1 (en) * | 2018-05-31 | 2021-04-14 | Ichnos Sciences S.A. | Anti-ox40 antagonistic antibodies and dosage for the treatment of ox40-mediated disorders |
| CN110577597B (zh) * | 2018-06-11 | 2021-10-22 | 康诺亚生物医药科技(成都)有限公司 | 一种阻断CD47和SIRPα相互作用的抗体 |
| KR20210031694A (ko) * | 2018-06-14 | 2021-03-22 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 엑토뉴클레오티다제 억제 및 항체-매개된 표적 사이토시스를 통한 t-세포 고갈을 예방 또는 역전시키는 조성물 및 방법 |
| JP7513533B2 (ja) * | 2018-07-02 | 2024-07-09 | アブセントラ,エルエルシー | リポタンパク質aの形成を減少させるための組成物及び方法、ならびに大動脈弁硬化症及び大動脈弁狭窄症の治療 |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| PL3820569T3 (pl) | 2018-07-12 | 2025-07-14 | Invox Pharma Limited | Cząsteczki przeciwciał, które wiążą PD-L1 oraz CD137 |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| BR112021000282A2 (pt) * | 2018-07-12 | 2021-04-06 | F-Star Beta Limited | Moléculas de anticorpo que se ligam a cd137 e ox40 |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| CN110713537B (zh) * | 2018-07-13 | 2023-04-21 | 江苏怀瑜药业有限公司 | 一种sema4d抗体及其制备方法和应用 |
| WO2020024931A1 (en) * | 2018-07-31 | 2020-02-06 | Shen Weiqun | Anti-il-17a antibodies and use thereof |
| WO2020033646A1 (en) * | 2018-08-08 | 2020-02-13 | Orionis Biosciences, Inc. | SIRP1α TARGETED CHIMERIC PROTEINS AND USES THEREOF |
| KR102666754B1 (ko) * | 2018-08-21 | 2024-05-17 | 에이비엘바이오 주식회사 | 항-pd-l1/항-lag3 이중 특이 항체 및 이의 용도 |
| CA3111396A1 (en) | 2018-09-06 | 2020-03-12 | The Trustees Of The University Of Pennsylvania | Humanized anti-c5 antibodies and uses thereof |
| CN111253485A (zh) * | 2018-11-30 | 2020-06-09 | 上海开拓者生物医药有限公司 | 抗人tim-3单克隆抗体及其应用 |
| CN113286825B (zh) * | 2018-11-30 | 2024-06-18 | 爱必乐生物公司 | 抗pd-l1/抗4-1bb双特异性抗体及其用途 |
| US12269874B2 (en) * | 2018-12-03 | 2025-04-08 | mAbProtein Co., Ltd. | Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof |
| US20220040230A1 (en) * | 2018-12-11 | 2022-02-10 | The Regents Of The University Of California | Compositions and methods for immunotherapies |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| AU2020221324A1 (en) * | 2019-02-15 | 2021-09-02 | University Of Southern California | Lym-1 and Lym-2 antibody compositions and improved CAR constructs |
| EP3924389A4 (en) * | 2019-02-15 | 2023-06-14 | Integral Molecular, Inc. | CLAUDIN-6 ANTIBODIES AND THEIR USES |
| CN113661175A (zh) | 2019-02-15 | 2021-11-16 | 整体分子公司 | 包含共同轻链的抗体及其用途 |
| EP3935083A4 (en) | 2019-03-03 | 2022-11-30 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2020206232A1 (en) * | 2019-04-04 | 2020-10-08 | Vanderbilt University | Hiv/hcv cross-reactive antibodies and uses thereof |
| EP3958903A4 (en) * | 2019-04-24 | 2023-08-02 | Janssen Biotech, Inc. | ANTIBODY FORMULATION |
| WO2020225736A1 (en) * | 2019-05-08 | 2020-11-12 | Novartis Ag | Anti-cd40 antibodies for use in treatment of t1dm and insulitis |
| TW202110878A (zh) * | 2019-05-16 | 2021-03-16 | 法商賽諾菲公司 | 在神經系統中表現抗原結合蛋白 |
| WO2020228806A1 (zh) * | 2019-05-16 | 2020-11-19 | 齐鲁制药有限公司 | 针对密蛋白18a2的抗体及其应用 |
| US20220235142A1 (en) * | 2019-06-04 | 2022-07-28 | Shanghai GenBase Biotechnology Co., Ltd. | Anti-ceacam5 monoclonal antibody, preparation method thereof and use thereof |
| WO2020250204A1 (ko) * | 2019-06-13 | 2020-12-17 | 프레스티지 바이오파마 피티이. 엘티디. | 신규 cthrc1에 특이적 항체 및 이의 용도 |
| FR3099160B1 (fr) * | 2019-07-23 | 2022-05-06 | Univ Grenoble Alpes | Anticorps dirigé contre la protéine oprf depseudomonas aeruginosa, son utilisation en tant que médicament et composition pharmaceutique le contenant |
| MY205369A (en) * | 2019-07-26 | 2024-10-17 | Sinocelltech Ltd | Humanized anti-il17a antibody and use thereof |
| MX2022001260A (es) * | 2019-07-31 | 2022-04-18 | Alector Llc | Anticuerpos anti-ms4a4a y metodos de uso de los mismos. |
| AU2020334893A1 (en) * | 2019-08-16 | 2022-02-24 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Chimeric antigen receptors for treating myeloid malignancies |
| WO2021057930A1 (en) * | 2019-09-26 | 2021-04-01 | Wuxi Biologics (Shanghai) Co., Ltd. | A novel anti-pd-l1/anti-lag-3 bispecific antibody and uses thereof |
| WO2021058718A1 (en) * | 2019-09-26 | 2021-04-01 | Roche Diagnostics Gmbh | Anti-csf-1r antibody |
| EP4041757A4 (en) * | 2019-09-26 | 2024-04-17 | Regents of the University of Minnesota | VIRAL ANTIGEN BINDING NK ENGAGERS COMPOUNDS AND METHODS OF USE |
| AU2020360849A1 (en) * | 2019-09-30 | 2022-04-14 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Protein binders to iRhom2 epitopes |
| EP4041308A1 (en) | 2019-10-07 | 2022-08-17 | University of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| AU2020380588A1 (en) * | 2019-11-04 | 2022-06-09 | Medimmune Limited | Anti IL-33 therapeutic agent FPR treating renal disorders |
| JP6761889B1 (ja) * | 2019-11-11 | 2020-09-30 | 株式会社Gspエンタープライズ | 抗ヒトCripto−1抗体 |
| US20220275103A1 (en) * | 2019-11-18 | 2022-09-01 | CentricsBio, Inc. | Anti-cd300c monoclonal antibody and biomarker thereof for preventing or treating cancer |
| WO2021102131A1 (en) * | 2019-11-21 | 2021-05-27 | Brown University | Bispecific antibodies against chi3l1 and ctla4 with enhanced cytotoxic effects on tumor cells |
| WO2021110930A1 (en) * | 2019-12-06 | 2021-06-10 | Universiteit Antwerpen | Combination immunotherapy of il-15 and cd40 agonist in cancer treatment |
| MX2022007688A (es) * | 2019-12-20 | 2022-07-19 | Amgen Inc | Constructos de anticuerpo multiespecificos agonistas de cd40 dirigidos a mesotelina para el tratamiento de tumores solidos. |
| WO2021146218A1 (en) * | 2020-01-13 | 2021-07-22 | Truebinding, Inc. | Anti-gal3 antibodies and methods of use |
| JP7449390B2 (ja) * | 2020-01-24 | 2024-03-13 | ファイザー・インク | 抗e-セレクチン抗体、組成物および使用の方法 |
| EP4093426A1 (en) | 2020-01-24 | 2022-11-30 | University of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| WO2021158178A1 (en) * | 2020-02-07 | 2021-08-12 | Agency For Science, Technology And Research | Antigen-binding molecules against alppl2 and/or alpp and uses thereof |
| MX2022009476A (es) * | 2020-02-10 | 2022-08-22 | Regeneron Pharma | Anticuerpos anti-tmprss2 y fragmentos de union a antigeno. |
| WO2021163346A2 (en) * | 2020-02-12 | 2021-08-19 | The Scripps Research Institute | Long-acting gm-csf and methods of use |
| WO2021162394A1 (ko) * | 2020-02-14 | 2021-08-19 | 충북대학교 산학협력단 | B세포 성숙화 항원을 표적으로 하는 키메라 항원 수용체 및 이의 용도 |
| GB202003632D0 (en) * | 2020-03-12 | 2020-04-29 | Harbour Antibodies Bv | SARS-Cov-2 (SARS2, COVID-19) antibodies |
| US20230192877A1 (en) * | 2020-03-30 | 2023-06-22 | National Institutes Of Biomedical Inovation, Health And Nutriton | Epitope region-bridging biparatopic antibody and method for producing same |
| CR20220552A (es) | 2020-04-02 | 2023-01-17 | Regeneron Pharma | Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno |
| KR102485892B1 (ko) * | 2020-04-09 | 2023-01-09 | 주식회사 에이프릴바이오 | 고양이 과립구 집락 자극인자 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질 및 이의 용도 |
| BR112022021604A2 (pt) * | 2020-04-28 | 2022-12-06 | Sola Biosciences Llc | Composições e métodos para tratamento de proteinopatias associadas à tdp-43 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| MX2022014734A (es) * | 2020-05-26 | 2023-03-15 | Regeneron Pharma | Metodos de tratamiento del cancer de cuello uterino mediante la administracion del anticuerpo inhibidor de pd-1 cemiplimab. |
| CN116323665A (zh) * | 2020-05-29 | 2023-06-23 | 23和我公司 | 抗cd200r1抗体及其使用方法 |
| KR20230020521A (ko) * | 2020-06-04 | 2023-02-10 | 셀벡스 피티와이 리미티드 | 아고니스트 항-cd40 항체 |
| US20230341408A1 (en) * | 2020-06-08 | 2023-10-26 | University Of Florida Research Foundation, Inc. | Materials and methods for the diagnosis and treatment of cancer |
| CA3182384A1 (en) * | 2020-06-18 | 2021-12-23 | Jay M. Short | Conditionally active anti-cd46 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| KR20230038706A (ko) * | 2020-07-16 | 2023-03-21 | 난징 레전드 바이오테크 씨오., 엘티디. | Cd19 결합 분자 및 이의 용도 |
| US20230257475A1 (en) * | 2020-07-16 | 2023-08-17 | Nanjing Legend Biotech Co., Ltd. | Multispecific chimeric antigen receptors and uses thereof |
| EP4182022A1 (en) | 2020-07-17 | 2023-05-24 | Boehringer Ingelheim International GmbH | Anti-il-36r antibodies for the treatment of neutrophilic dermatoses |
| EP4188960A4 (en) * | 2020-08-03 | 2024-09-11 | Janssen Biotech, Inc. | MATERIALS AND METHODS FOR MULTIDIRECTIONAL BIOTRANSPORTATION IN VIROTHERAPEUTIC PRODUCTS |
| WO2022034920A1 (en) * | 2020-08-14 | 2022-02-17 | Chugai Seiyaku Kabushiki Kaisha | One-armed antigen-binding molecules and uses thereof |
| US12129290B2 (en) * | 2020-08-18 | 2024-10-29 | Omeros Corporation | Monoclonal antibodies, compositions and methods for detecting complement factor D |
| EP4199968A1 (en) * | 2020-08-20 | 2023-06-28 | Ambrx, Inc. | Antibody-tlr agonist conjugates, methods and uses thereof |
| TWI818308B (zh) * | 2020-09-03 | 2023-10-11 | 大陸商和鉑醫藥(上海)有限責任公司 | 標靶ror1的抗體或其抗原結合片段及製備方法和應用 |
| US12448449B2 (en) * | 2020-09-11 | 2025-10-21 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
| US11905332B2 (en) | 2020-09-18 | 2024-02-20 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind CD38 and/or CD28, and uses thereof |
| KR20230088370A (ko) * | 2020-09-18 | 2023-06-19 | 아이크노스 사이언스 에스. 아. | Cd47-cd38 이중특이성 항체 |
| WO2022068141A1 (zh) * | 2020-09-29 | 2022-04-07 | 昆明赛诺制药股份有限公司 | 人源化抗-cd22重组免疫毒素及其应用 |
| WO2022072508A1 (en) * | 2020-09-30 | 2022-04-07 | Dren Bio, Inc. | Anti-cd94 antibodies and methods of use thereof |
| EP4236988A4 (en) * | 2020-10-30 | 2024-10-30 | Rush University Medical Center | INTRANASAL IMMUNOTHERAPY FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| CN117264060A (zh) * | 2020-11-09 | 2023-12-22 | 江苏中新医药有限公司 | 抗胞外-5’-核苷酸酶的抗体及其在制备肿瘤药物中的应用 |
| CN114470189B (zh) * | 2020-11-12 | 2024-01-16 | 达石药业(广东)有限公司 | Ngf抗体在cipn性疼痛中的应用 |
| JP7326584B2 (ja) * | 2020-12-17 | 2023-08-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗hla-g抗体及びその使用 |
| AR124410A1 (es) * | 2020-12-18 | 2023-03-22 | Ac Immune Sa | Administración de anticuerpos |
| US12325752B2 (en) * | 2020-12-18 | 2025-06-10 | Regeneron Pharmaceuticals, Inc. | Immunoglobulin proteins that bind to NPR1 agonists |
| CN116635426A (zh) * | 2021-01-08 | 2023-08-22 | 北京韩美药品有限公司 | 特异性结合cd47的抗体及其抗原结合片段 |
| CA3204552A1 (en) * | 2021-01-08 | 2022-07-14 | Joseph M. LUETTGEN | Antibodies and antigen binding peptides for factor xia inhibitors and uses thereof |
| CA3209006A1 (en) * | 2021-03-04 | 2022-09-09 | Boehringer Ingelheim International Gmbh | Methods for the treatment of gpp |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Cd3及びcldn6に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) * | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Cd3及びgpc3に結合するヘテロ二量体抗体 |
| MX2023010917A (es) * | 2021-03-18 | 2023-09-27 | Medimmune Ltd | Molecula de union terapeutica que se une a ccr9. |
| TW202304988A (zh) * | 2021-03-24 | 2023-02-01 | 美商健生生物科技公司 | 靶向CD79b、CD20、及CD3之三特異性抗體 |
| CN118165109A (zh) * | 2021-03-31 | 2024-06-11 | 美勒斯公司 | 包含新颖pd-1结合域之多特异性结合部分 |
| US11993654B2 (en) * | 2021-03-31 | 2024-05-28 | Merus N.V. | PD-1 binding domains |
| PE20232050A1 (es) * | 2021-04-06 | 2023-12-27 | Teneobio Inc | Anticuerpos anti-cd19 y estructuras car-t |
| CN115260312B (zh) * | 2021-04-30 | 2025-02-14 | 保诺科技(北京)有限公司 | 结合ox40的抗体或抗原结合片段 |
| WO2022271884A2 (en) * | 2021-06-22 | 2022-12-29 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| TWI864408B (zh) * | 2021-06-25 | 2024-12-01 | 日商中外製藥股份有限公司 | 抗ctla-4抗體的用途 |
| AU2022299846B2 (en) * | 2021-06-25 | 2024-08-15 | Chugai Seiyaku Kabushiki Kaisha | Anti–ctla-4 antibody |
| US12448451B2 (en) * | 2021-06-25 | 2025-10-21 | Chugai Seiyaku Kabushiki Kaisha | Anti-CTLA-4 antibody and use thereof |
| IL310012A (en) * | 2021-07-14 | 2024-03-01 | Regeneron Pharma | Antibodies against SARS-COV-2 spike glycoprotein and antigen-binding fragments |
| US11542340B1 (en) * | 2021-10-29 | 2023-01-03 | Biodesix, Inc. | Antibodies targeting pulmonary nodule specific biomarkers and uses thereof |
| IL313265A (en) | 2021-12-06 | 2024-08-01 | Regeneron Pharma | Antagonistic antibodies against NPR1 and methods of using them |
| EP4626933A1 (en) | 2022-11-30 | 2025-10-08 | Integral Molecular, Inc. | Antibodies directed to claudin 6, including bispecific formats thereof |
| CN120513256A (zh) * | 2023-01-20 | 2025-08-19 | 迈威(美国)生物治疗有限公司 | 抗淀粉样蛋白β原纤丝/低聚物抗体和其用途 |
| US20240285789A1 (en) * | 2023-02-23 | 2024-08-29 | University Of Utah Research Foundation | Compositions and Methods for Killing PD-1 Positive Cells |
| WO2024194686A2 (en) | 2023-03-17 | 2024-09-26 | Oxitope Pharma B.V. | Anti-phosphocholine antibodies and methods of use thereof |
| WO2025257181A1 (en) * | 2024-06-11 | 2025-12-18 | Institut National de la Santé et de la Recherche Médicale | Antibodies targeting trans-active response dna-binding protein-43 (tdp-43) |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| AU584417B2 (en) | 1985-04-01 | 1989-05-25 | Lonza Group Ag | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| JPS6296086A (ja) | 1985-10-21 | 1987-05-02 | Agency Of Ind Science & Technol | 複合プラスミド |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| US4857467A (en) | 1986-07-23 | 1989-08-15 | Phillips Petroleum Company | Carbon and energy source markers for transformation of strains of the genes Pichia |
| GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| DK159088C (da) | 1988-04-06 | 1991-01-28 | Oce Helioprint As | Skanner til aftastning af en original |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| WO1990001063A1 (en) | 1988-07-23 | 1990-02-08 | Delta Biotechnology Limited | New secretory leader sequences |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| GB8924021D0 (en) | 1989-10-25 | 1989-12-13 | Celltech Ltd | Recombinant dna method and vectors for the use therein |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| WO1998052976A1 (en) | 1997-05-21 | 1998-11-26 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US20040214167A9 (en) | 2000-12-28 | 2004-10-28 | Akio Matsuda | NF-kappa B activating gene |
| MXPA05012722A (es) | 2003-05-27 | 2006-05-25 | Attenuon Llc | Analogos de tiotungstato y sus usos. |
| WO2008042190A2 (en) | 2006-09-29 | 2008-04-10 | The Trustees Of The University Of Pennsylvania | Detection of neurodegenerative disease |
| US8354236B2 (en) | 2006-09-29 | 2013-01-15 | The Trustees Of The University Of Pennsylvania | Detection of neurodegenerative disease |
| US9557271B2 (en) | 2008-09-25 | 2017-01-31 | Mohammad A. Mazed | Optical biomodule for detection of diseases |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| WO2008151055A1 (en) | 2007-06-01 | 2008-12-11 | Mayo Foundation For Medical Education And Research | Diagnosing neurodegenerative diseases |
| WO2009008529A1 (ja) | 2007-07-06 | 2009-01-15 | Tokyo Metropolitan Organization For Medical Research | Tdp-43凝集物に特異的に結合する抗体 |
| GB0719287D0 (en) | 2007-10-03 | 2007-11-14 | Univ Manchester | Prognostic or diagnostic test |
| CA2713871C (en) | 2008-02-01 | 2018-05-22 | Washington University In St. Louis | Sequences associated with tdp-43 proteinopathies and methods of using the same |
| EP2272955B1 (en) | 2008-04-09 | 2015-08-26 | Tokyo Metropolitan Institute of Medical Science | Tdp-43-storing cell model |
| KR20110013409A (ko) * | 2008-05-23 | 2011-02-09 | 삼성전자주식회사 | 항체-펩티드 융합 상승체 |
| WO2010015040A1 (en) | 2008-08-07 | 2010-02-11 | Powmri Ltd | Therapy and prevention of tdp-43 proteinopathy |
| JP5756014B2 (ja) * | 2008-08-08 | 2015-07-29 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ(エイ・スター) | がんの診断および治療のためのvhz |
| US20110230551A1 (en) | 2008-09-15 | 2011-09-22 | Leslie Gunatilaka | Withaferin a analogs and uses thereof |
| WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
| US20110287953A1 (en) | 2010-05-21 | 2011-11-24 | Chi-Ying Huang | Method for discovering potential drugs |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| US8598339B2 (en) | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
| US20140120562A1 (en) | 2011-06-22 | 2014-05-01 | Universite Laval | Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease |
-
2014
- 2014-12-05 CA CA2874083A patent/CA2874083C/en active Active
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2015
- 2015-12-07 AU AU2015358266A patent/AU2015358266A1/en not_active Abandoned
- 2015-12-07 US US15/532,909 patent/US10202443B2/en active Active
- 2015-12-07 JP JP2017529766A patent/JP6882172B2/ja active Active
- 2015-12-07 EP EP15864525.9A patent/EP3227330B1/en active Active
- 2015-12-07 WO PCT/CA2015/051280 patent/WO2016086320A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2016086320A1 (en) | 2016-06-09 |
| EP3227330A4 (en) | 2018-10-31 |
| JP2018502561A (ja) | 2018-02-01 |
| EP3227330A1 (en) | 2017-10-11 |
| EP3227330C0 (en) | 2024-01-17 |
| AU2021250947A1 (en) | 2021-11-11 |
| US20170355756A1 (en) | 2017-12-14 |
| CA2874083C (en) | 2024-01-02 |
| CA2874083A1 (en) | 2016-06-05 |
| AU2015358266A1 (en) | 2017-06-29 |
| EP3227330B1 (en) | 2024-01-17 |
| US10202443B2 (en) | 2019-02-12 |
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