JP6877387B2 - 安定化次亜ハロゲン酸溶液 - Google Patents
安定化次亜ハロゲン酸溶液 Download PDFInfo
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- JP6877387B2 JP6877387B2 JP2018103205A JP2018103205A JP6877387B2 JP 6877387 B2 JP6877387 B2 JP 6877387B2 JP 2018103205 A JP2018103205 A JP 2018103205A JP 2018103205 A JP2018103205 A JP 2018103205A JP 6877387 B2 JP6877387 B2 JP 6877387B2
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- hypochlorous acid
- afc
- hydrogel preparation
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Images
Classifications
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Description
本出願は、それぞれ参照することにより本明細書にその全体が組み込まれる、2011年3月18日出願の米国仮特許出願第61/454,383号、および2011年8月22日出願の米国仮特許出願第61/526,149号の利益および優先権を主張する。
安定化次亜塩素酸溶液
図1および2は、2つの環境条件、すなわち低温(C)および室温(R)における、時間の関数としての次亜塩素酸創傷処置溶液のAFCおよびpH測定の5サイクルを示す。示されるように、pHおよびAFC含量の両方が、長期にわたり安定化されなかった。例えば、溶液は、約1週間超の間、安定化されなかった。
安定化HOCl溶液の殺生物活性
異なる濃度の次亜塩素酸を含む3種の溶液を生成した。NaCl 4.2g/LおよびNaHCO3 400mg/Lを含む電解質の電気化学的処理により、250ppmの次亜塩素酸を含有する第1の溶液を生成した。同様に電気化学的処理で生成された第2の溶液は、480ppmの次亜塩素酸を含有したが、NaHCO3は含有しなかった。最後の溶液は、480ppmの次亜塩素酸を含有したが、それに加えてNaHCO3 1000mg/Lを組み込んでいた。
長期安定性試験
図6は、ポリエチレンテレフタレート(PET)容器内に瓶詰めされ、室温で保管された、目標pH5.4のNaHCO3が豊富なNaCl溶液の電気化学的処理により生成されたHOClの、長期安定性試験の結果を示す。NaHCO3のモル含量は、この製剤中の1モルのHOCl当たり1モルのNaHCO3と等価である。保管期間にわたり、隔月にHOCl安定化溶液の4つの新たな試料を開封し、次いで1ヶ月後に再び開封し、週1回試験した。最初に開封された試料のpHおよびAFCを、最後に開封された、その月の間週1回開封された試料と比較することにより、重炭酸ナトリウムで安定化されたHOClの安定性が確認された。
添加された重炭酸ナトリウムによるHOClの安定性
乾燥重炭酸ナトリウムを含む容器に加えられたHOClの安定性を、図7Aおよび7Bに示す。イオン強度または溶液塩分は、重炭酸ナトリウムの添加により影響されなかった。結果は、安定剤としての重炭酸塩が、pHおよびAFC安定性の両方に影響することを実証している。いかなる理論にも束縛されないが、pHが約5.5であり、重炭酸塩の緩衝能力が最小限である場合、重炭酸塩は、1つには次亜塩素酸の解離により生成されるフリーラジカルを捕捉することにより、安定剤として作用し得る。その結果、pHおよびAFCの経時的な降下は最小限である。
農業用途のHOCl組成物の安定性
電気化学的に生成され、さらに目標pHのためにリン酸二ナトリウムおよび一ナトリウムで緩衝された次亜塩素酸溶液(農業用途における実用性を有する)におけるpHおよび溶液安定性に対するDIC含量の効果を、図8に示す。リン酸塩添加剤を含む次亜塩素酸の組成物を、重炭酸塩あり、およびなしで試験した。結果は、リン酸塩単独よりも、重炭酸塩の存在下で次亜塩素酸がより良好に安定であることを示した。DICおよびリン酸緩衝液の組合せは、全溶解固形分を著しく増加させることなく、より良好な溶液安定性を提供した。
ヒドロゲル製剤
安定化次亜塩素酸溶液を含有する、ヒドロゲル製剤を開発した。本発明による重炭酸塩または溶解無機炭素の使用は、溶液のイオン強度または電気伝導率に対し最小限の影響を有するにすぎない。したがって、約4〜約7.5のpH範囲(例えば約6.0)でHOCl溶液を安定化することに加えて、重炭酸塩または炭酸塩は、目標pHにおいてイオン強度に影響せず、特に低イオン強度が製剤に重要である場合に、ゲル製剤中の分散媒体としての200ppmを超える遊離有効塩素を有する次亜塩素酸の使用を可能にする。
Claims (18)
- 次亜塩素酸と、アルカリまたはアルカリ土類金属の重炭酸塩または炭酸塩の形態の安定量の溶解無機炭素(DIC)とを含むヒドロゲル製剤であって、
前記ヒドロゲル製剤が、100〜1,000ppmの遊離有効塩素(AFC)含量、4.0〜7のpH、5:1〜1:5のAFCに対するDICのモル比を有し、DICは炭酸塩、重炭酸塩、炭酸、及びCO 2 の含量を含む、
ヒドロゲル製剤。 - 0.5%〜5%のシリケート含有担体を含む、
請求項1記載のヒドロゲル製剤。 - 前記シリケート含有担体が、フルオロケイ酸ナトリウムマグネシウムである、
請求項2記載のヒドロゲル製剤。 - 前記AFC含量が100〜500ppmである、請求項1〜3のいずれかに記載のヒドロゲル製剤。
- 前記AFC含量が150〜250ppmである、請求項1〜4のいずれかに記載のヒドロゲル製剤。
- 前記AFC含量が300ppm超である、請求項1〜3のいずれかに記載のヒドロゲル製剤。
- 前記pHが4.4〜7である、請求項1〜6のいずれかに記載のヒドロゲル製剤。
- 前記pHが5〜7である、請求項1〜7のいずれかに記載のヒドロゲル製剤。
- 前記pHが5〜6.4である、請求項1〜8のいずれかに記載のヒドロゲル製剤。
- 0.5mS/cm〜12mS/cmの電気伝導率を有する、請求項1〜9のいずれかに記載のヒドロゲル製剤。
- 1mS/cm〜10mS/cmの電気伝導率を有する、請求項1〜10のいずれかに記載のヒドロゲル製剤。
- AFCに対するDICのモル比が、2:1〜1:2である、請求項1〜11のいずれかに記載のヒドロゲル製剤。
- DICの量が、AFC含量と等モルである、請求項1〜12のいずれかに記載のヒドロゲル製剤。
- DICが重炭酸ナトリウムとして組み込まれる、請求項1〜13のいずれかに記載のヒドロゲル製剤。
- 前記次亜塩素酸が、NaCl溶液の電気分解により調製される、請求項1〜14のいずれかに記載のヒドロゲル製剤。
- 前記重炭酸塩または炭酸塩が電気分解後に組み込まれる、請求項15に記載のヒドロゲル製剤。
- 0.01〜0.1%の塩分を有する、請求項1〜16のいずれかに記載のヒドロゲル製剤。
- 前記ヒドロゲル製剤が容器内にパッケージされており、前記容器がCO2またはO2に対して最小限の透過性を有する、請求項1〜17のいずれかに記載のヒドロゲル製剤。
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