JP6824044B2 - 真菌感染症の治療方法 - Google Patents
真菌感染症の治療方法 Download PDFInfo
- Publication number
- JP6824044B2 JP6824044B2 JP2016575387A JP2016575387A JP6824044B2 JP 6824044 B2 JP6824044 B2 JP 6824044B2 JP 2016575387 A JP2016575387 A JP 2016575387A JP 2016575387 A JP2016575387 A JP 2016575387A JP 6824044 B2 JP6824044 B2 JP 6824044B2
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- alkyl
- substituted
- group
- csa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- YDYLISNLJUDIGF-MWSAZPCCSA-N CCCCCCCCNCCC[C@@H](C)[C@@H](CC[C@H]1C([C@H](C2)[C@@](C)(CC[C@H](C3)OCCCN)[C@@H]3C3)[C@@H]3OCCCN)[C@@]1(C)[C@H]2OCCCN Chemical compound CCCCCCCCNCCC[C@@H](C)[C@@H](CC[C@H]1C([C@H](C2)[C@@](C)(CC[C@H](C3)OCCCN)[C@@H]3C3)[C@@H]3OCCCN)[C@@]1(C)[C@H]2OCCCN YDYLISNLJUDIGF-MWSAZPCCSA-N 0.000 description 1
- DCOJJZCALNXQRN-PHGLHFJMSA-N CCCCCCOC(CC[C@@H](C)[C@@H](CC[C@H]1[C@@H]([C@H](C2)[C@@](C)(CC[C@H](C3)OC(CCN)=O)[C@@H]3C3)[C@@H]3OC(CCN)=O)[C@@]1(C)[C@H]2OC(CCN)=O)=O Chemical compound CCCCCCOC(CC[C@@H](C)[C@@H](CC[C@H]1[C@@H]([C@H](C2)[C@@](C)(CC[C@H](C3)OC(CCN)=O)[C@@H]3C3)[C@@H]3OC(CCN)=O)[C@@]1(C)[C@H]2OC(CCN)=O)=O DCOJJZCALNXQRN-PHGLHFJMSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462017788P | 2014-06-26 | 2014-06-26 | |
| US62/017,788 | 2014-06-26 | ||
| US14/750,928 US10441595B2 (en) | 2014-06-26 | 2015-06-25 | Methods for treating fungal infections |
| US14/750,928 | 2015-06-25 | ||
| PCT/US2015/038029 WO2015200815A1 (en) | 2014-06-26 | 2015-06-26 | Methods for treating fungal infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020120053A Division JP7101413B2 (ja) | 2014-06-26 | 2020-07-13 | 真菌感染症の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519036A JP2017519036A (ja) | 2017-07-13 |
| JP2017519036A5 JP2017519036A5 (enExample) | 2018-08-09 |
| JP6824044B2 true JP6824044B2 (ja) | 2021-02-03 |
Family
ID=54929350
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575387A Active JP6824044B2 (ja) | 2014-06-26 | 2015-06-26 | 真菌感染症の治療方法 |
| JP2020120053A Active JP7101413B2 (ja) | 2014-06-26 | 2020-07-13 | 真菌感染症の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020120053A Active JP7101413B2 (ja) | 2014-06-26 | 2020-07-13 | 真菌感染症の治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10441595B2 (enExample) |
| EP (1) | EP3229808B1 (enExample) |
| JP (2) | JP6824044B2 (enExample) |
| KR (1) | KR102601412B1 (enExample) |
| CN (2) | CN114588166A (enExample) |
| AU (1) | AU2015279652B2 (enExample) |
| BR (1) | BR112016030541B1 (enExample) |
| CA (1) | CA2953136C (enExample) |
| WO (1) | WO2015200815A1 (enExample) |
Families Citing this family (25)
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|---|---|---|---|---|
| US20110150955A1 (en) | 2009-12-23 | 2011-06-23 | Shannon Elizabeth Klingman | Products and Methods for Reducing Malodor from the Pudendum |
| CA2842462C (en) | 2011-07-20 | 2020-01-28 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
| AU2014203882B2 (en) | 2013-01-07 | 2016-06-23 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| RU2669800C2 (ru) | 2013-03-15 | 2018-10-16 | Брихэм Янг Юниверсити | Способы лечения воспаления, аутоиммунных расстройств и боли |
| US11690855B2 (en) * | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| US10441595B2 (en) * | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US20180272034A1 (en) * | 2017-03-21 | 2018-09-27 | Brigham Young University | Use of csa compounds to prevent microbial build-up or fouling of medical implants |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| WO2018204506A1 (en) * | 2017-05-03 | 2018-11-08 | Genberg Carl | Methods for treating fungal infections |
| US20190167579A1 (en) * | 2017-10-27 | 2019-06-06 | Pulmatrix Operating Company, Inc. | Itraconazole dry powders |
| FR3073738A1 (fr) * | 2017-11-17 | 2019-05-24 | Balmes Transplantation | Nouveaux medicaments cytoprotecteurs |
| CN112423755A (zh) * | 2018-04-18 | 2021-02-26 | 希普拉技术有限责任公司 | 治疗真菌感染的方法 |
| US12186328B2 (en) | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| US12157869B2 (en) | 2019-07-10 | 2024-12-03 | Jeffrey Dean Lindsay | Methods and compositions for reducing persistent odor in clothing and mitigating biofilms on various materials |
| WO2021216399A1 (en) * | 2020-04-20 | 2021-10-28 | Enterin, Inc. | Pulmonary aminosterol compositions and methods of using the same to treat microbial infections |
| US12215126B2 (en) | 2020-05-21 | 2025-02-04 | Brigham Young University | Cationic steroidal antimicrobial compounds with endogenous groups |
| US20250073248A1 (en) * | 2023-09-05 | 2025-03-06 | Brigham Young University | Bioresorbable cationic steroidal antimicrobial compounds with glyceride linkages |
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| CN114588166A (zh) | 2022-06-07 |
| AU2015279652B2 (en) | 2017-11-23 |
| US20150374719A1 (en) | 2015-12-31 |
| KR20170045197A (ko) | 2017-04-26 |
| CA2953136C (en) | 2023-04-04 |
| BR112016030541A2 (pt) | 2018-11-27 |
| CN106900172A (zh) | 2017-06-27 |
| JP7101413B2 (ja) | 2022-07-15 |
| AU2015279652A1 (en) | 2017-01-12 |
| WO2015200815A1 (en) | 2015-12-30 |
| JP2020180153A (ja) | 2020-11-05 |
| KR102601412B1 (ko) | 2023-11-13 |
| BR112016030541B1 (pt) | 2022-12-20 |
| EP3229808A4 (en) | 2018-03-07 |
| JP2017519036A (ja) | 2017-07-13 |
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