CN106900172A - 用于治疗真菌感染的方法 - Google Patents

用于治疗真菌感染的方法 Download PDF

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Publication number
CN106900172A
CN106900172A CN201580045470.2A CN201580045470A CN106900172A CN 106900172 A CN106900172 A CN 106900172A CN 201580045470 A CN201580045470 A CN 201580045470A CN 106900172 A CN106900172 A CN 106900172A
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CN
China
Prior art keywords
unsubstituted
alkyl
substituted
aminoalkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580045470.2A
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English (en)
Chinese (zh)
Inventor
卡尔·A·吉尼伯格
查德·S·伯斯
保罗·B·萨维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
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Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Brigham Young University filed Critical Brigham Young University
Priority to CN202210362688.2A priority Critical patent/CN114588166A/zh
Publication of CN106900172A publication Critical patent/CN106900172A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN201580045470.2A 2014-06-26 2015-06-26 用于治疗真菌感染的方法 Pending CN106900172A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210362688.2A CN114588166A (zh) 2014-06-26 2015-06-26 用于治疗真菌感染的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462017788P 2014-06-26 2014-06-26
US62/017,788 2014-06-26
US14/750,928 US10441595B2 (en) 2014-06-26 2015-06-25 Methods for treating fungal infections
US14/750,928 2015-06-25
PCT/US2015/038029 WO2015200815A1 (en) 2014-06-26 2015-06-26 Methods for treating fungal infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210362688.2A Division CN114588166A (zh) 2014-06-26 2015-06-26 用于治疗真菌感染的方法

Publications (1)

Publication Number Publication Date
CN106900172A true CN106900172A (zh) 2017-06-27

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580045470.2A Pending CN106900172A (zh) 2014-06-26 2015-06-26 用于治疗真菌感染的方法
CN202210362688.2A Pending CN114588166A (zh) 2014-06-26 2015-06-26 用于治疗真菌感染的方法

Family Applications After (1)

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Country Status (9)

Country Link
US (1) US10441595B2 (enExample)
EP (1) EP3229808B1 (enExample)
JP (2) JP6824044B2 (enExample)
KR (1) KR102601412B1 (enExample)
CN (2) CN106900172A (enExample)
AU (1) AU2015279652B2 (enExample)
BR (1) BR112016030541B1 (enExample)
CA (1) CA2953136C (enExample)
WO (1) WO2015200815A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111405904A (zh) * 2017-11-17 2020-07-10 巴勒姆移植 新型细胞保护药物
CN112423755A (zh) * 2018-04-18 2021-02-26 希普拉技术有限责任公司 治疗真菌感染的方法

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US20110150955A1 (en) 2009-12-23 2011-06-23 Shannon Elizabeth Klingman Products and Methods for Reducing Malodor from the Pudendum
ES2725784T3 (es) 2011-07-20 2019-09-27 Univ Brigham Young Compuestos de ceragenina hidrófobos y dispositivos que incorporan al mismo
EP2941253B1 (en) 2013-01-07 2021-08-11 Brigham Young University Cationic steroid antimicrobial agents for use in treating cancer
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CN110420211A (zh) 2013-03-15 2019-11-08 布莱阿姆青年大学 治疗炎症、自身免疫性疾病和疼痛的方法
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) * 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
WO2016172553A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US9434759B1 (en) * 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US20180272034A1 (en) * 2017-03-21 2018-09-27 Brigham Young University Use of csa compounds to prevent microbial build-up or fouling of medical implants
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US20190167579A1 (en) * 2017-10-27 2019-06-06 Pulmatrix Operating Company, Inc. Itraconazole dry powders
US12186328B2 (en) * 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth
US12157869B2 (en) 2019-07-10 2024-12-03 Jeffrey Dean Lindsay Methods and compositions for reducing persistent odor in clothing and mitigating biofilms on various materials
WO2021216399A1 (en) * 2020-04-20 2021-10-28 Enterin, Inc. Pulmonary aminosterol compositions and methods of using the same to treat microbial infections
US12215126B2 (en) 2020-05-21 2025-02-04 Brigham Young University Cationic steroidal antimicrobial compounds with endogenous groups
US20250073248A1 (en) * 2023-09-05 2025-03-06 Brigham Young University Bioresorbable cationic steroidal antimicrobial compounds with glyceride linkages
WO2025101647A1 (en) * 2023-11-06 2025-05-15 The Research Foundation For The State University Of New York Combination therapy of itraconazole and acylhydrazone-based antifungalagents for the treatment of sporotrichosis in cats

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