KR102601412B1 - 진균 감염 치료 방법 - Google Patents

진균 감염 치료 방법 Download PDF

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KR102601412B1
KR102601412B1 KR1020177002469A KR20177002469A KR102601412B1 KR 102601412 B1 KR102601412 B1 KR 102601412B1 KR 1020177002469 A KR1020177002469 A KR 1020177002469A KR 20177002469 A KR20177002469 A KR 20177002469A KR 102601412 B1 KR102601412 B1 KR 102601412B1
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KR20170045197A (ko
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칼 에이. 겐버그
차드 에스. 베어스
폴 비. 세비지
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브라이엄 영 유니버시티
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
KR1020177002469A 2014-06-26 2015-06-26 진균 감염 치료 방법 Active KR102601412B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462017788P 2014-06-26 2014-06-26
US62/017,788 2014-06-26
US14/750,928 US10441595B2 (en) 2014-06-26 2015-06-25 Methods for treating fungal infections
US14/750,928 2015-06-25
PCT/US2015/038029 WO2015200815A1 (en) 2014-06-26 2015-06-26 Methods for treating fungal infections

Publications (2)

Publication Number Publication Date
KR20170045197A KR20170045197A (ko) 2017-04-26
KR102601412B1 true KR102601412B1 (ko) 2023-11-13

Family

ID=54929350

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177002469A Active KR102601412B1 (ko) 2014-06-26 2015-06-26 진균 감염 치료 방법

Country Status (9)

Country Link
US (1) US10441595B2 (enExample)
EP (1) EP3229808B1 (enExample)
JP (2) JP6824044B2 (enExample)
KR (1) KR102601412B1 (enExample)
CN (2) CN114588166A (enExample)
AU (1) AU2015279652B2 (enExample)
BR (1) BR112016030541B1 (enExample)
CA (1) CA2953136C (enExample)
WO (1) WO2015200815A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110150955A1 (en) 2009-12-23 2011-06-23 Shannon Elizabeth Klingman Products and Methods for Reducing Malodor from the Pudendum
CA2842462C (en) 2011-07-20 2020-01-28 Brigham Young University Hydrogel materials incorporating eluting ceragenin compound
AU2014203882B2 (en) 2013-01-07 2016-06-23 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
RU2669800C2 (ru) 2013-03-15 2018-10-16 Брихэм Янг Юниверсити Способы лечения воспаления, аутоиммунных расстройств и боли
US11690855B2 (en) * 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
US10441595B2 (en) * 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US9527883B2 (en) 2015-04-22 2016-12-27 Brigham Young University Methods for the synthesis of ceragenins
US9434759B1 (en) * 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US20180272034A1 (en) * 2017-03-21 2018-09-27 Brigham Young University Use of csa compounds to prevent microbial build-up or fouling of medical implants
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
WO2018204506A1 (en) * 2017-05-03 2018-11-08 Genberg Carl Methods for treating fungal infections
US20190167579A1 (en) * 2017-10-27 2019-06-06 Pulmatrix Operating Company, Inc. Itraconazole dry powders
FR3073738A1 (fr) * 2017-11-17 2019-05-24 Balmes Transplantation Nouveaux medicaments cytoprotecteurs
CN112423755A (zh) * 2018-04-18 2021-02-26 希普拉技术有限责任公司 治疗真菌感染的方法
US12186328B2 (en) 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth
US12157869B2 (en) 2019-07-10 2024-12-03 Jeffrey Dean Lindsay Methods and compositions for reducing persistent odor in clothing and mitigating biofilms on various materials
WO2021216399A1 (en) * 2020-04-20 2021-10-28 Enterin, Inc. Pulmonary aminosterol compositions and methods of using the same to treat microbial infections
US12215126B2 (en) 2020-05-21 2025-02-04 Brigham Young University Cationic steroidal antimicrobial compounds with endogenous groups
US20250073248A1 (en) * 2023-09-05 2025-03-06 Brigham Young University Bioresorbable cationic steroidal antimicrobial compounds with glyceride linkages
WO2025101647A1 (en) * 2023-11-06 2025-05-15 The Research Foundation For The State University Of New York Combination therapy of itraconazole and acylhydrazone-based antifungalagents for the treatment of sporotrichosis in cats

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042058A1 (en) 1999-01-19 2000-07-20 Brigham Young University Steroid derived antibiotics
US20040058974A1 (en) 2002-09-23 2004-03-25 Schering Corporation Treating fungal infections
WO2007089907A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
KR100897938B1 (ko) 2007-05-30 2009-05-18 주식회사 제넥신 면역글로불린 융합 단백질
WO2010036427A1 (en) * 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2013040265A1 (en) 2011-09-13 2013-03-21 Brigham Young University Technology Commercialization Office Compositions for treating bone diseases and broken bones
WO2015058087A1 (en) 2013-10-17 2015-04-23 Genberg, Carl A. Methods for treating lung infections and inflammation

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1037074B (de) 1957-03-25 1958-08-21 Schering Ag Mundpflegemittel
US4248236A (en) 1978-12-26 1981-02-03 Linder Gerald S Packaged medical appliance
US4296206A (en) 1980-04-30 1981-10-20 United States Of America Irreversible anti-glucocorticoids
US4661341A (en) 1984-10-30 1987-04-28 The Procter & Gamble Company Oral compositions
US4723950A (en) 1984-12-12 1988-02-09 C. R. Bard, Inc. Urine drainage bag outlet with barrier against microbial infection
US5506354A (en) 1985-09-12 1996-04-09 The Upjohn Company Imidazolylpiperazinyl steroids
US4842593A (en) 1987-10-09 1989-06-27 The Procter & Gamble Company Disposable absorbent articles for incontinent individuals
US4865855A (en) 1988-01-11 1989-09-12 Kimberly-Clark Corporation Antimicrobial absorbent food pad
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4972848A (en) 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
US5025754A (en) 1990-02-01 1991-06-25 David Plyler Apparatus and method for providing drinking water to poultry
JPH0474026A (ja) 1990-07-16 1992-03-09 Nippon Telegr & Teleph Corp <Ntt> 移動通信における接続制御方法
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5310545A (en) 1991-04-11 1994-05-10 Drore Eisen Method of treatment using mouthwashes containing steroids and antifungal agents and compositions of matter
US5286479A (en) 1991-12-10 1994-02-15 The Dow Chemical Company Oral compositions for suppressing mouth odors
US5234703A (en) 1992-10-31 1993-08-10 Guthery B Eugene Disinfecting product and process
JP2877636B2 (ja) 1992-11-18 1999-03-31 積水化成品工業株式会社 抗菌性ドリップシート
HU222244B1 (hu) 1993-03-12 2003-05-28 Pharmacia & Upjohn Co. Szabad sav formájában lévő kristályos ceftiofur, ennek előállítása és ezt tartalmazó gyógyászati készítmény
US5407573A (en) 1993-06-01 1995-04-18 Alpine Water Purification, Inc. Continuous flow water-purifying device
ATE210144T1 (de) 1994-03-10 2001-12-15 Magainin Pharma Verwendung von steroidderivaten als arzneimittel
US5856535A (en) 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5624704A (en) 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5763430A (en) 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
DK0832094T3 (da) * 1995-06-07 2004-05-17 Genaera Corp Aminosterolforbindelser, som er nyttige som inhibitorer for natrium/proton-omskifteren (NHE), farmaceutiske fremgangsmåder og sammensætninger, som anvender sådanne inhibitorer, og fremgangsmåder til vurdering af den NHE-inhiberende effektivitet af for..
US5687714A (en) 1995-10-10 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services Self-cleaning endotracheal tube apparatus
JP3044367B2 (ja) 1995-11-13 2000-05-22 三洋化成工業株式会社 抗菌性吸水剤組成物およびその製法
US6132765A (en) 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US5897770A (en) 1997-10-23 1999-04-27 Plymouth Products, Inc. Center core cartridge feeder insert
US20040170563A1 (en) 1997-10-27 2004-09-02 Meade Thomas J. Magnetic resonance imaging agents for the delivery of therapeutic agents
ATE269086T1 (de) 1998-03-06 2004-07-15 Univ Brigham Young Antibiotische steroidderivate
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6329488B1 (en) 1998-11-10 2001-12-11 C. R. Bard, Inc. Silane copolymer coatings
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
NO307168B1 (no) 1999-03-01 2000-02-21 Orix As Oralt preparat som er effektivt mot halitose
US6673771B1 (en) 1999-07-28 2004-01-06 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
WO2001014406A1 (en) 1999-08-23 2001-03-01 Chugai Seiyaku Kabushiki Kaisha Antiandrogen agents
US6551608B2 (en) 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
WO2001076650A1 (en) 2000-04-06 2001-10-18 University Technology Corporation Compositions and methods for promoting wound healing
EP1311531B1 (en) 2000-08-15 2016-05-11 Brigham Young University Steroid derived antibiotics
JP3435405B2 (ja) 2000-11-24 2003-08-11 株式会社ティーセル研究所 家畜の乳房炎治療剤及びこれを用いた乳房炎の治療方法
US6514556B2 (en) 2000-12-15 2003-02-04 Ecolab Inc. Method and composition for washing poultry during processing
US6803066B2 (en) 2001-01-18 2004-10-12 Praxair Technology, Inc. Sanitizing food products
JP4674980B2 (ja) 2001-02-26 2011-04-20 サンスター株式会社 アルコール無配合液体口腔用組成物
MXPA03007672A (es) 2001-02-26 2004-11-12 Univ Sydney Metodo para mejorar la funcion de crecimiento de un animal.
ES2189649B1 (es) 2001-06-15 2004-09-16 Oftrai S.L. Nueva composicion desinfectante y antiseptica.
US6921390B2 (en) 2001-07-23 2005-07-26 Boston Scientific Scimed, Inc. Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
US9056048B2 (en) 2001-08-16 2015-06-16 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
AU2002324723B2 (en) 2001-08-16 2007-10-25 The Trustees Of The University Of Pennsylvania Synthesis and use of reagents for improved DNA lipofection and/or slow release pro-drug and drug therapies
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US7048956B2 (en) 2002-03-05 2006-05-23 The Penn State Research Foundation Process for antimicrobial treatment of fresh produce, particularly mushrooms
DE10218147B4 (de) 2002-04-23 2005-12-22 Stockhausen Gmbh Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung
US7334580B2 (en) 2002-05-07 2008-02-26 Smaldone Gerald C Methods, devices and formulations for targeted endobronchial therapy
US6689342B1 (en) 2002-07-29 2004-02-10 Warner-Lambert Company Oral care compositions comprising tropolone compounds and essential oils and methods of using the same
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7659061B2 (en) 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US7282214B2 (en) 2002-12-19 2007-10-16 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
JP2006151812A (ja) * 2003-01-30 2006-06-15 Meiji Seika Kaisha Ltd 新規トリアゾール誘導体及びこれを有効成分とする抗真菌剤
AU2004222523A1 (en) 2003-03-20 2004-09-30 Pharmacia Corporation Dispersible formulation of an anti-inflammatory agent
NZ543643A (en) 2003-06-23 2007-09-28 Beiersdorf Ag Antimicrobial wound dressing with two layers and antimicrobial metal between layers but not on exterior
DE10328261B4 (de) 2003-06-23 2007-10-25 Beiersdorf Ag Desinfizierende Auflage mit Silberbeschichtung und ihre Verwendung
US20070134292A1 (en) 2003-07-17 2007-06-14 Esa Suokas Synthetic, bioabsorbable polymer materials and implants
GB0318901D0 (en) 2003-08-12 2003-09-17 Univ Bath Improvements in or relating to bone substitute material
US6872303B2 (en) 2003-08-12 2005-03-29 Ian M. Knapp Water treatment cartridge
US20050267051A1 (en) 2003-12-19 2005-12-01 Lee Henry J Antineoplastic and anti-HIV conjugates of steroid acid and nucleosides
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20060062773A1 (en) 2004-09-21 2006-03-23 The Procter & Gamble Company Compositions for maintaining and restoring normal gastrointestinal flora
US20100092398A1 (en) 2004-09-30 2010-04-15 Max Reynolds Antimicrobial compositions and applications therefore
US20080077025A1 (en) 2005-07-11 2008-03-27 Leticia Delgado-Herrera Methods for determining how to treat congestive heart failure
HUE025071T2 (en) 2005-08-26 2016-01-28 Becton Dickinson Co Method for sterilizing elastomeric articles
ES2661728T3 (es) 2005-10-03 2018-04-03 Pinksky, Mark A. Composiciones y métodos para el cuidado mejorado de la piel
US20070191322A1 (en) 2006-02-01 2007-08-16 Savage Paul B Cationic Steroid Microbial Compositions and Methods of Use
WO2008048340A2 (en) 2006-02-01 2008-04-24 Brigham Young University Cationic steroid antimicrobial compositions for treating poxvirus infections
WO2007089906A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions for treating or preventing herpes infections
JP4366507B2 (ja) 2006-03-20 2009-11-18 国立大学法人北陸先端科学技術大学院大学 酸化蛋白質の定量方法
WO2007134176A2 (en) 2006-05-10 2007-11-22 Microban Products Company Antimicrobial food pad
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
US20110135742A1 (en) 2006-06-20 2011-06-09 The Regents Of The University Of California Controlled release encapsulated anti-bacterial and anti-inflammatory nanoparticles
US8685421B2 (en) 2006-07-07 2014-04-01 Surmodics, Inc. Beaded wound spacer device
US20100022481A1 (en) 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
WO2008038965A1 (en) 2006-09-26 2008-04-03 Kyungpook National University Industry-Academic Cooperation Foundation 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient
BRPI0718543A2 (pt) 2006-11-06 2013-11-12 Novartis Ag Dispositivos oculares e métodos de fabricação e uso dos mesmos
US7854941B2 (en) 2007-02-12 2010-12-21 The University Of Southern Mississippi Method of attaching drug compounds to non-reactive polymer surfaces
JP2008311504A (ja) 2007-06-15 2008-12-25 Toshiba Corp 半導体集積回路
US20090016973A1 (en) 2007-07-09 2009-01-15 Micropure, Inc. Composition and Method for the Prevention of Oral Disease
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8558051B2 (en) 2007-07-18 2013-10-15 The Procter & Gamble Company Disposable absorbent article having odor control system
US8772220B2 (en) 2007-08-24 2014-07-08 Sekisui Specialty Chemicals America, Llc Chemical delivery product and process for making the same
US20090068122A1 (en) 2007-09-06 2009-03-12 Shira Pilch Dentifrice Compositions for Treating Xerostomia
WO2009079066A2 (en) 2007-09-26 2009-06-25 Aparna Biosciences Therapeutic and vaccine polyelectrolyte nanoparticle compositions
US20090099531A1 (en) 2007-10-15 2009-04-16 Griesbach Iii Henry Louis Packaging for selectivity lubricating part of a medical device
RU2483074C2 (ru) 2007-10-16 2013-05-27 Проджен Фармасьютикалз Лимитед Новые сульфатированные производные олигосахаридов
GB0724278D0 (en) 2007-12-13 2008-01-30 Syntopix Ltd uses for antimicrobial agents
WO2009144708A1 (en) 2008-04-14 2009-12-03 Ganot, Arie Augmentation and treatment of gingival defects
US20090324517A1 (en) 2008-06-30 2009-12-31 Dan Kline Halitosis treatment
CA2730085A1 (en) 2008-07-09 2010-01-14 Board Of Regents Of The University Of Nebraska Functional micelles for hard tissue targeted delivery of chemicals
WO2011066260A2 (en) 2009-11-25 2011-06-03 Michael Zasloff Formulations comprising aminosterols
US8529681B1 (en) 2010-01-07 2013-09-10 Sandia Corporation Biofouling-resistant ceragenin-modified materials and structures for water treatment
US9180132B2 (en) 2010-03-04 2015-11-10 The Trustees Of The University Of Pennsylvania Antimicrobial cationic steroids and methods of use
JP5720103B2 (ja) 2010-03-18 2015-05-20 東レ株式会社 シリコーンハイドロゲル、眼用レンズおよびコンタクトレンズ
KR101134342B1 (ko) 2010-04-22 2012-04-09 주식회사 메가젠임플란트 치과용 임플란트의 픽스츄어 및 그를 구비하는 임플란트 시술용 세트
US8871716B2 (en) 2010-10-08 2014-10-28 Korea Advanced Institute Of Science And Technology Use of antimicrobial peptides in regeneration of skin cells
RU2576459C2 (ru) 2010-11-03 2016-03-10 Брайем Янг Юниверсити Устойчивые при хранении антимикробные композиции, включающие церагениновые соединения, и способы их применения
GB201021937D0 (en) 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
CN102172356B (zh) 2011-03-03 2013-04-03 山东农业大学 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用
US20130004586A1 (en) 2011-06-24 2013-01-03 Vachon David J Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same
CA2842462C (en) 2011-07-20 2020-01-28 Brigham Young University Hydrogel materials incorporating eluting ceragenin compound
WO2013029055A1 (en) 2011-08-25 2013-02-28 Brigham Young University Incorporation of particulate ceragenins in polymers
US8932614B2 (en) 2011-08-25 2015-01-13 Paul B. Savage Incorporation of particulate ceragenins in polymers
WO2013029059A1 (en) 2011-08-25 2013-02-28 Brigham Young University Medical devices incorporating ceragenin-containing composites
EP2755661A1 (en) 2011-09-13 2014-07-23 Brigham Young University Compositions for treating bone diseases and broken bones
AU2011383326B2 (en) 2011-12-15 2016-01-28 Colgate-Palmolive Company Aqueous oral care compositions
JP6051230B2 (ja) 2011-12-21 2016-12-27 ブリガム ヤング ユニバーシティ 口腔ケア組成物
US20140363780A1 (en) 2011-12-21 2014-12-11 Brigham Young University Oral care compositions
BR112014021505A2 (pt) 2012-03-01 2017-07-18 Univ Brigham Young composições de processamento de alimentos antimicrobianas incluindo compostos de ceragenina e métodos de uso
US20130280391A1 (en) 2012-04-24 2013-10-24 Brigham Young University Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products
EP3225113B1 (en) 2012-05-02 2020-09-02 Brigham Young University Methods for making ceragenin particulate materials
EP2846788A1 (en) 2012-05-11 2015-03-18 Akron Molecules AG Use of compounds for the treatment of pain
KR20140029864A (ko) 2012-08-30 2014-03-11 삼성디스플레이 주식회사 표시 장치 및 이를 이용한 에어 터치 인식 방법 및 이를 이용한 입체 영상 표시 방법
US9314472B2 (en) 2012-10-17 2016-04-19 Brigham Young University Treatment and prevention of mastitis
PL2900277T3 (pl) 2012-12-13 2022-05-16 Immunomedics, Inc. Dawkowanie immunokoniugatów przeciwciał i sn-38 dla poprawy skuteczności i zmniejszenia toksyczności
AU2014203882B2 (en) 2013-01-07 2016-06-23 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
RU2669800C2 (ru) 2013-03-15 2018-10-16 Брихэм Янг Юниверсити Способы лечения воспаления, аутоиммунных расстройств и боли
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US10441595B2 (en) * 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
AU2016250816B2 (en) 2015-04-22 2020-10-22 Brigham Young University Cationic steroidal antimicrobial salts
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US9527883B2 (en) 2015-04-22 2016-12-27 Brigham Young University Methods for the synthesis of ceragenins
US9434759B1 (en) 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US20170080128A1 (en) 2015-09-21 2017-03-23 Brigham Young University Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042058A1 (en) 1999-01-19 2000-07-20 Brigham Young University Steroid derived antibiotics
US20040058974A1 (en) 2002-09-23 2004-03-25 Schering Corporation Treating fungal infections
WO2007089907A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
US20070190067A1 (en) 2006-02-01 2007-08-16 Savage Paul B Cationic Steroid Antimicrobial Compositions and Methods of Use
KR100897938B1 (ko) 2007-05-30 2009-05-18 주식회사 제넥신 면역글로불린 융합 단백질
WO2010036427A1 (en) * 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2013040265A1 (en) 2011-09-13 2013-03-21 Brigham Young University Technology Commercialization Office Compositions for treating bone diseases and broken bones
US20130243823A1 (en) 2011-09-13 2013-09-19 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
WO2015058087A1 (en) 2013-10-17 2015-04-23 Genberg, Carl A. Methods for treating lung infections and inflammation

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