JP6791873B2 - イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用 - Google Patents

イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用 Download PDF

Info

Publication number
JP6791873B2
JP6791873B2 JP2017551589A JP2017551589A JP6791873B2 JP 6791873 B2 JP6791873 B2 JP 6791873B2 JP 2017551589 A JP2017551589 A JP 2017551589A JP 2017551589 A JP2017551589 A JP 2017551589A JP 6791873 B2 JP6791873 B2 JP 6791873B2
Authority
JP
Japan
Prior art keywords
pyrazole
methyl
formula
solvate
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017551589A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018510191A (ja
JP2018510191A5 (enExample
Inventor
フックス,トーマス
シーマン,カイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2018510191A publication Critical patent/JP2018510191A/ja
Publication of JP2018510191A5 publication Critical patent/JP2018510191A5/ja
Application granted granted Critical
Publication of JP6791873B2 publication Critical patent/JP6791873B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017551589A 2015-04-02 2016-03-31 イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用 Active JP6791873B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15000968.6 2015-04-02
EP15000968 2015-04-02
PCT/EP2016/000542 WO2016155884A1 (de) 2015-04-02 2016-03-31 Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020185129A Division JP7111790B2 (ja) 2015-04-02 2020-11-05 イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用

Publications (3)

Publication Number Publication Date
JP2018510191A JP2018510191A (ja) 2018-04-12
JP2018510191A5 JP2018510191A5 (enExample) 2019-05-16
JP6791873B2 true JP6791873B2 (ja) 2020-11-25

Family

ID=52814780

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017551589A Active JP6791873B2 (ja) 2015-04-02 2016-03-31 イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用
JP2020185129A Active JP7111790B2 (ja) 2015-04-02 2020-11-05 イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020185129A Active JP7111790B2 (ja) 2015-04-02 2020-11-05 イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用

Country Status (23)

Country Link
US (5) US10457677B2 (enExample)
EP (3) EP3277681B1 (enExample)
JP (2) JP6791873B2 (enExample)
KR (2) KR102652052B1 (enExample)
CN (3) CN107889488B (enExample)
AU (4) AU2016239270B2 (enExample)
BR (1) BR122019005502B1 (enExample)
DK (2) DK3277681T3 (enExample)
ES (3) ES2880626T3 (enExample)
HR (2) HRP20191396T1 (enExample)
HU (2) HUE054745T2 (enExample)
IL (3) IL254714B (enExample)
LT (2) LT3560924T (enExample)
MX (2) MX376947B (enExample)
PL (2) PL3560924T3 (enExample)
PT (2) PT3560924T (enExample)
RS (2) RS59139B1 (enExample)
RU (1) RU2743343C2 (enExample)
SG (2) SG11201708065QA (enExample)
SI (2) SI3277681T1 (enExample)
TR (1) TR201911244T4 (enExample)
WO (1) WO2016155884A1 (enExample)
ZA (1) ZA201707423B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021046403A (ja) * 2015-04-02 2021-03-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) * 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
CN110312717B (zh) * 2017-02-27 2022-04-12 上海瑛派药业有限公司 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CN111587126A (zh) 2018-01-12 2020-08-25 普罗林科斯有限责任公司 组合剂型和用于验证的造影剂毒性最小化方案
AU2019233596A1 (en) * 2018-03-14 2020-10-08 Merck Patent Gmbh Compounds and uses thereof to treat tumors in a subject
EP3904349B1 (en) 2018-04-12 2023-08-23 Bayer Aktiengesellschaft N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}heterocyclyl amide derivatives and similar compounds as pesticides
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
GB201814487D0 (en) * 2018-09-06 2018-10-24 Cycle Pharmaceuticals Ltd Cancer
CN109045042A (zh) * 2018-09-21 2018-12-21 上海交通大学医学院附属上海儿童医学中心 Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用
AU2019348132B2 (en) * 2018-09-30 2022-03-31 Medshine Discovery Inc. Quinolino-pyrrolidin-2-one derivative and application thereof
LT3947375T (lt) 2019-03-27 2024-06-10 Merck Patent Gmbh Imidazolonilchinolino junginiai ir jų terapinis panaudojimas
WO2021022078A1 (en) * 2019-07-30 2021-02-04 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
KR20220095205A (ko) * 2019-11-01 2022-07-06 아레스 트레이딩 에스.아. 암의 치료를 위한 방사선요법과 PD-1, TGFβ 및 ATM의 조합 억제
AU2020398215A1 (en) * 2019-12-04 2022-06-16 Chdi Foundation, Inc. ATM kinase inhibitors and compositions and methods of use thereof
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
WO2021197339A1 (zh) * 2020-03-30 2021-10-07 南京明德新药研发有限公司 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用
US20230226041A1 (en) * 2020-06-18 2023-07-20 Merck Patent Gmbh Compounds for the treatment of viral infections
WO2021260580A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atm inhibitor
CA3190226A1 (en) 2020-09-18 2022-03-24 Merck Patent Gmbh Pharmaceutical preparation
WO2022060377A1 (en) * 2020-09-21 2022-03-24 Wei Zhong Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
CN115232122B (zh) * 2021-04-23 2024-05-31 石药集团中奇制药技术(石家庄)有限公司 炔类化合物及其制备和应用
CN115716829B (zh) * 2022-11-13 2024-05-31 药康众拓(江苏)医药科技有限公司 一种喹啉并咪唑酮联氘代吡唑类化合物及其应用
KR20250112837A (ko) 2022-11-23 2025-07-24 포워드 테라퓨틱스, 인코포레이티드 TNF-α 활성의 조절제
WO2025157979A1 (en) 2024-01-26 2025-07-31 Merck Patent Gmbh Synthesis route for preparing 8-(1,3-dimethyl-1h-pyrazol-4-yl)-1-(sa)-(3-fluoro-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one
WO2025212627A1 (en) 2024-04-03 2025-10-09 Forward Therapeutics, Inc. Modulators of tnf-alpha activity
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DE60001623T2 (de) * 1999-12-03 2003-12-18 Pfizer Products Inc., Groton Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
PL1879893T3 (pl) * 2005-03-21 2010-11-30 Ferrer Int Sposób otrzymywania podstawionych w pozycji 1, związków 1H-imidazo[4,5-c]chinolino-4-aminowych i związki pośrednie
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
EP1934201A1 (en) * 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
BRPI0807893A2 (pt) 2007-02-20 2014-06-17 Novartis Ag Imidazoquinolinas como inibidores duais de lipídio quinase e mtor.
CA2925257C (en) 2008-03-26 2019-04-30 Carlos Garcia-Echeverria 5imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes
CA3000973A1 (en) 2008-06-10 2009-12-17 Abbvie Inc. Tricyclic compounds
CN102170873B (zh) 2008-10-01 2014-07-30 诺华股份有限公司 用于治疗与hedgehog通路有关的病症的smoothened拮抗
US8476294B2 (en) 2009-06-04 2013-07-02 Novartis Ag 1H-imidazo[4,5-c]quinolinone derivatives
JP2012528829A (ja) 2009-06-04 2012-11-15 ノバルティス アーゲー 1H−イミダゾ[4,5−c]キノリノン化合物
GB0919423D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
EA201201289A1 (ru) * 2010-03-16 2013-08-30 Мерк Патент Гмбх Морфолинилхиназолины
SG186855A1 (en) * 2010-06-28 2013-02-28 Merck Patent Gmbh 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer
CN102372711B (zh) 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
DE102010035744A1 (de) 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) 2010-09-16 2012-04-04 和记黄埔医药(上海)有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
WO2012075253A2 (en) 2010-12-03 2012-06-07 Novartis Ag Pharmaceutical compositions
CN103012398B (zh) 2011-09-19 2015-10-14 上海恒瑞医药有限公司 咪唑并喹啉类衍生物及其可药用盐、其制备方法及其在医药上的应用
US9879003B2 (en) 2012-04-11 2018-01-30 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
WO2013184621A1 (en) 2012-06-06 2013-12-12 Novartis Ag Combination of a 17 -alpha -hydroxylase (c17, 20 - lyase) inhibitor and a specific pi-3k inhibitor for treating a tumor disease
NO2714752T3 (enExample) * 2014-05-08 2018-04-21
US10457677B2 (en) 2015-04-02 2019-10-29 Merck Patent Gmbh Imidazolonylquinolines and the use thereof as ATM kinase inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021046403A (ja) * 2015-04-02 2021-03-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用
JP7111790B2 (ja) 2015-04-02 2022-08-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用

Also Published As

Publication number Publication date
KR102652052B1 (ko) 2024-03-27
DK3560924T3 (da) 2021-06-28
SI3277681T1 (sl) 2019-09-30
DK3277681T3 (da) 2019-07-29
JP2018510191A (ja) 2018-04-12
US10975075B2 (en) 2021-04-13
US20180072715A1 (en) 2018-03-15
US10457677B2 (en) 2019-10-29
US20210198257A1 (en) 2021-07-01
JP2021046403A (ja) 2021-03-25
RS62082B1 (sr) 2021-08-31
EP3560924A1 (de) 2019-10-30
BR122019005502B1 (pt) 2024-02-27
US20200325137A1 (en) 2020-10-15
IL254714A0 (en) 2017-11-30
HRP20210981T1 (hr) 2021-09-17
KR20240044525A (ko) 2024-04-04
AU2025200385A1 (en) 2025-02-13
EP3868761B1 (de) 2023-03-01
MX390537B (es) 2025-03-20
IL254714B (en) 2020-01-30
AU2022256215A1 (en) 2022-11-24
LT3277681T (lt) 2019-08-12
LT3560924T (lt) 2021-08-25
TR201911244T4 (tr) 2019-08-21
EP3277681B1 (de) 2019-05-08
CN111689963A (zh) 2020-09-22
IL282584B (en) 2021-12-01
NZ774407A (en) 2024-09-27
SI3560924T1 (sl) 2021-08-31
IL271494A (en) 2020-02-27
HUE054745T2 (hu) 2021-09-28
CN107889488A (zh) 2018-04-06
RU2743343C2 (ru) 2021-02-17
ES2741853T3 (es) 2020-02-12
AU2016239270A1 (en) 2017-11-16
US10745399B2 (en) 2020-08-18
ZA201707423B (en) 2021-05-26
PL3277681T3 (pl) 2019-10-31
US20230203034A1 (en) 2023-06-29
ES2880626T3 (es) 2021-11-25
MX2017012613A (es) 2018-01-24
SG11201708065QA (en) 2017-10-30
RU2017138100A3 (enExample) 2019-10-04
RU2017138100A (ru) 2019-05-08
BR112017020941A2 (pt) 2018-07-10
HRP20191396T1 (hr) 2019-11-01
CA2981365A1 (en) 2016-10-06
SG10202002181UA (en) 2020-05-28
IL271494B (en) 2021-05-31
KR20170132323A (ko) 2017-12-01
US20190211013A1 (en) 2019-07-11
CN107889488B (zh) 2020-08-11
JP7111790B2 (ja) 2022-08-02
IL282584A (en) 2021-06-30
WO2016155884A1 (de) 2016-10-06
NZ736641A (en) 2024-09-27
MX376947B (es) 2025-03-07
AU2016239270B2 (en) 2020-03-26
AU2020204241A1 (en) 2020-07-16
PT3560924T (pt) 2021-07-02
EP3560924B1 (de) 2021-03-31
PT3277681T (pt) 2019-08-20
AU2020204241B2 (en) 2022-11-17
RS59139B1 (sr) 2019-09-30
CN111747952A (zh) 2020-10-09
US11608338B2 (en) 2023-03-21
PL3560924T3 (pl) 2021-10-11
ES2946507T3 (es) 2023-07-20
EP3868761A1 (de) 2021-08-25
HUE045477T2 (hu) 2019-12-30
MX2020011558A (es) 2022-03-09
EP3277681A1 (de) 2018-02-07

Similar Documents

Publication Publication Date Title
JP7111790B2 (ja) イミダゾロニルキノリンおよびatmキナーゼ阻害剤としてのその使用
CN105358552B (zh) 芳基喹唑啉
ES2788348T3 (es) Derivados heterocíclicos tricíclicos
CA2981365C (en) Imidazolonylquinolines and the use thereof as atm kinase inhibitors
BR112017020941B1 (pt) Imidazolonilquinolinas, seus usos, composições farmacêuticas, e kit
KR20210100612A (ko) 시클로알칸-1,3-디아민 유도체
HK1221719B (en) Arylquinazolines

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190401

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190401

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200123

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200205

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200507

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201007

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201105

R150 Certificate of patent or registration of utility model

Ref document number: 6791873

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250