IL254714B - History of quinoline and pharmaceutical preparations containing them - Google Patents

History of quinoline and pharmaceutical preparations containing them

Info

Publication number
IL254714B
IL254714B IL254714A IL25471417A IL254714B IL 254714 B IL254714 B IL 254714B IL 254714 A IL254714 A IL 254714A IL 25471417 A IL25471417 A IL 25471417A IL 254714 B IL254714 B IL 254714B
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
IL254714A
Other languages
English (en)
Hebrew (he)
Other versions
IL254714A0 (en
Inventor
Kai Schiemann
Thomas Fuchss
Original Assignee
Merck Patent Gmbh
Kai Schiemann
Thomas Fuchss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Kai Schiemann, Thomas Fuchss filed Critical Merck Patent Gmbh
Publication of IL254714A0 publication Critical patent/IL254714A0/en
Publication of IL254714B publication Critical patent/IL254714B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL254714A 2015-04-02 2017-09-26 History of quinoline and pharmaceutical preparations containing them IL254714B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15000968 2015-04-02
PCT/EP2016/000542 WO2016155884A1 (de) 2015-04-02 2016-03-31 Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

Publications (2)

Publication Number Publication Date
IL254714A0 IL254714A0 (en) 2017-11-30
IL254714B true IL254714B (en) 2020-01-30

Family

ID=52814780

Family Applications (3)

Application Number Title Priority Date Filing Date
IL254714A IL254714B (en) 2015-04-02 2017-09-26 History of quinoline and pharmaceutical preparations containing them
IL271494A IL271494B (en) 2015-04-02 2019-12-17 History of quinoline and pharmaceutical preparations containing them
IL282584A IL282584B (en) 2015-04-02 2021-04-22 History of quinoline and pharmaceutical preparations containing them

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL271494A IL271494B (en) 2015-04-02 2019-12-17 History of quinoline and pharmaceutical preparations containing them
IL282584A IL282584B (en) 2015-04-02 2021-04-22 History of quinoline and pharmaceutical preparations containing them

Country Status (24)

Country Link
US (5) US10457677B2 (enExample)
EP (3) EP3868761B1 (enExample)
JP (2) JP6791873B2 (enExample)
KR (2) KR20240044525A (enExample)
CN (3) CN107889488B (enExample)
AU (4) AU2016239270B2 (enExample)
BR (1) BR122019005502B1 (enExample)
CA (1) CA2981365A1 (enExample)
DK (2) DK3277681T3 (enExample)
ES (3) ES2741853T3 (enExample)
HR (2) HRP20191396T1 (enExample)
HU (2) HUE045477T2 (enExample)
IL (3) IL254714B (enExample)
LT (2) LT3560924T (enExample)
MX (2) MX390537B (enExample)
PL (2) PL3277681T3 (enExample)
PT (2) PT3277681T (enExample)
RS (2) RS62082B1 (enExample)
RU (1) RU2743343C2 (enExample)
SG (2) SG11201708065QA (enExample)
SI (2) SI3277681T1 (enExample)
TR (1) TR201911244T4 (enExample)
WO (1) WO2016155884A1 (enExample)
ZA (1) ZA201707423B (enExample)

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US11547703B2 (en) 2017-02-27 2023-01-10 Impact Therapeutics (Shanghai), Inc Substituted fused heteroaromatic tricyclic compounds as kinase inhibitors and the use thereof
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
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EP3904350B1 (en) 2018-04-12 2023-08-23 Bayer Aktiengesellschaft N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
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KR102345208B1 (ko) 2018-09-30 2021-12-30 메드샤인 디스커버리 아이엔씨. 퀴놀리노-피롤리딘-2-온 유도체 및 이의 응용
JP2022526926A (ja) 2019-03-27 2022-05-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング イミダゾロニルキノリン化合物およびそれらの治療への使用
EP4003345B1 (en) * 2019-07-30 2024-12-04 XRad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
JP2023501971A (ja) * 2019-11-01 2023-01-20 アレス トレーディング ソシエテ アノニム 癌の治療のための、放射線療法と共に用いるPD-1、TGFβ、及びATMの組み合わせ阻害
WO2021113506A1 (en) * 2019-12-04 2021-06-10 Chdi Foundation, Inc. Atm kinase inhibitors and compositions and methods of use thereof
WO2021139814A1 (zh) * 2020-01-09 2021-07-15 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
WO2021197339A1 (zh) * 2020-03-30 2021-10-07 南京明德新药研发有限公司 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用
JP2023530004A (ja) * 2020-06-18 2023-07-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス感染症の処置のための化合物
TW202216209A (zh) 2020-06-24 2022-05-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及atm抑制劑之組合
US20230330027A1 (en) 2020-09-18 2023-10-19 Merck Patent Gmbh Pharmaceutical preparation
WO2022060377A1 (en) * 2020-09-21 2022-03-24 Wei Zhong Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
CN115232122B (zh) * 2021-04-23 2024-05-31 石药集团中奇制药技术(石家庄)有限公司 炔类化合物及其制备和应用
CN115716829B (zh) * 2022-11-13 2024-05-31 药康众拓(江苏)医药科技有限公司 一种喹啉并咪唑酮联氘代吡唑类化合物及其应用
CN120418259A (zh) 2022-11-23 2025-08-01 弗沃德医疗公司 TNFα活性的调节剂
WO2025157979A1 (en) 2024-01-26 2025-07-31 Merck Patent Gmbh Synthesis route for preparing 8-(1,3-dimethyl-1h-pyrazol-4-yl)-1-(sa)-(3-fluoro-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one
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Also Published As

Publication number Publication date
EP3560924A1 (de) 2019-10-30
AU2022256215A1 (en) 2022-11-24
TR201911244T4 (tr) 2019-08-21
CN111689963A (zh) 2020-09-22
NZ736641A (en) 2024-09-27
ES2946507T3 (es) 2023-07-20
PT3277681T (pt) 2019-08-20
MX390537B (es) 2025-03-20
MX2017012613A (es) 2018-01-24
US10745399B2 (en) 2020-08-18
AU2020204241B2 (en) 2022-11-17
ES2880626T3 (es) 2021-11-25
US20200325137A1 (en) 2020-10-15
RU2017138100A3 (enExample) 2019-10-04
AU2016239270A1 (en) 2017-11-16
HUE045477T2 (hu) 2019-12-30
DK3277681T3 (da) 2019-07-29
US20180072715A1 (en) 2018-03-15
KR20170132323A (ko) 2017-12-01
JP7111790B2 (ja) 2022-08-02
HRP20210981T1 (hr) 2021-09-17
IL282584A (en) 2021-06-30
HRP20191396T1 (hr) 2019-11-01
CN111747952A (zh) 2020-10-09
EP3560924B1 (de) 2021-03-31
LT3277681T (lt) 2019-08-12
PT3560924T (pt) 2021-07-02
RS62082B1 (sr) 2021-08-31
RU2743343C2 (ru) 2021-02-17
CA2981365A1 (en) 2016-10-06
MX376947B (es) 2025-03-07
DK3560924T3 (da) 2021-06-28
ZA201707423B (en) 2021-05-26
SG10202002181UA (en) 2020-05-28
EP3277681B1 (de) 2019-05-08
LT3560924T (lt) 2021-08-25
AU2016239270B2 (en) 2020-03-26
IL282584B (en) 2021-12-01
AU2020204241A1 (en) 2020-07-16
JP2021046403A (ja) 2021-03-25
US20190211013A1 (en) 2019-07-11
NZ774407A (en) 2024-09-27
CN107889488B (zh) 2020-08-11
US10975075B2 (en) 2021-04-13
SI3277681T1 (sl) 2019-09-30
US10457677B2 (en) 2019-10-29
US20210198257A1 (en) 2021-07-01
EP3277681A1 (de) 2018-02-07
SI3560924T1 (sl) 2021-08-31
ES2741853T3 (es) 2020-02-12
MX2020011558A (es) 2022-03-09
KR102652052B1 (ko) 2024-03-27
RU2017138100A (ru) 2019-05-08
PL3277681T3 (pl) 2019-10-31
BR112017020941A2 (pt) 2018-07-10
HUE054745T2 (hu) 2021-09-28
SG11201708065QA (en) 2017-10-30
JP6791873B2 (ja) 2020-11-25
PL3560924T3 (pl) 2021-10-11
WO2016155884A1 (de) 2016-10-06
IL271494A (en) 2020-02-27
JP2018510191A (ja) 2018-04-12
AU2025200385A1 (en) 2025-02-13
IL254714A0 (en) 2017-11-30
KR20240044525A (ko) 2024-04-04
US11608338B2 (en) 2023-03-21
EP3868761A1 (de) 2021-08-25
BR122019005502B1 (pt) 2024-02-27
EP3868761B1 (de) 2023-03-01
US20230203034A1 (en) 2023-06-29
IL271494B (en) 2021-05-31
CN107889488A (zh) 2018-04-06
RS59139B1 (sr) 2019-09-30

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