ES2741853T3 - Imidazolonilquinolinas y su uso como inhibidores de ATM cinasa - Google Patents

Info

Publication number

ES2741853T3

ES2741853T3 ES16717560T ES16717560T ES2741853T3 ES 2741853 T3 ES2741853 T3 ES 2741853T3 ES 16717560 T ES16717560 T ES 16717560T ES 16717560 T ES16717560 T ES 16717560T ES 2741853 T3 ES2741853 T3 ES 2741853T3

Authority

ES

Spain

Prior art keywords

pyrazol

fluoro

tautomer

stereoisomer

solvate

Prior art date

2015-04-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229940043355 kinase inhibitor Drugs 0.000 title description 5
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 5
• BAHVJMJZUDCTPT-UHFFFAOYSA-N 4-quinolin-2-ylimidazol-2-one Chemical class O=C1N=CC(C=2N=C3C=CC=CC3=CC=2)=N1 BAHVJMJZUDCTPT-UHFFFAOYSA-N 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 158
• -1 3-difluoromethoxy-5-fluoro-pyridin-4-yl Chemical group 0.000 claims abstract description 75
• 150000003839 salts Chemical class 0.000 claims abstract description 52
• 239000012453 solvate Substances 0.000 claims abstract description 34
• 229910052801 chlorine Inorganic materials 0.000 claims abstract description 10
• 229910052731 fluorine Inorganic materials 0.000 claims abstract description 10
• 229910052794 bromium Inorganic materials 0.000 claims abstract description 8
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
• 229910052740 iodine Inorganic materials 0.000 claims abstract description 6
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 5
• 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
• 125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 3
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