CN107889488B - 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 - Google Patents

咪唑酮基喹啉和其作为atm激酶抑制剂的用途 Download PDF

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CN107889488B
CN107889488B CN201680031887.8A CN201680031887A CN107889488B CN 107889488 B CN107889488 B CN 107889488B CN 201680031887 A CN201680031887 A CN 201680031887A CN 107889488 B CN107889488 B CN 107889488B
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methyl
pyrazol
fluoro
compound
het
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CN107889488A (zh
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T.富克斯
K.席曼
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680031887.8A 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 Active CN107889488B (zh)

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CN202010644289.6A CN111689963A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
CN202010644109.4A CN111747952A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途

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EP15000968 2015-04-02
EP15000968.6 2015-04-02
PCT/EP2016/000542 WO2016155884A1 (de) 2015-04-02 2016-03-31 Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

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CN202010644289.6A Division CN111689963A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途

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CN202010644289.6A Pending CN111689963A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
CN202010644109.4A Pending CN111747952A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途

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CN202010644109.4A Pending CN111747952A (zh) 2015-04-02 2016-03-31 咪唑酮基喹啉和其作为atm激酶抑制剂的用途

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NZ736641A (en) 2024-09-27
ES2946507T3 (es) 2023-07-20
PT3277681T (pt) 2019-08-20
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US10745399B2 (en) 2020-08-18
AU2020204241B2 (en) 2022-11-17
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US20200325137A1 (en) 2020-10-15
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CN111747952A (zh) 2020-10-09
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US10975075B2 (en) 2021-04-13
SI3277681T1 (sl) 2019-09-30
US10457677B2 (en) 2019-10-29
US20210198257A1 (en) 2021-07-01
EP3277681A1 (de) 2018-02-07
SI3560924T1 (sl) 2021-08-31
ES2741853T3 (es) 2020-02-12
MX2020011558A (es) 2022-03-09
KR102652052B1 (ko) 2024-03-27
RU2017138100A (ru) 2019-05-08
PL3277681T3 (pl) 2019-10-31
BR112017020941A2 (pt) 2018-07-10
HUE054745T2 (hu) 2021-09-28
SG11201708065QA (en) 2017-10-30
JP6791873B2 (ja) 2020-11-25
PL3560924T3 (pl) 2021-10-11
WO2016155884A1 (de) 2016-10-06
IL271494A (en) 2020-02-27
JP2018510191A (ja) 2018-04-12
AU2025200385A1 (en) 2025-02-13
IL254714A0 (en) 2017-11-30
KR20240044525A (ko) 2024-04-04
US11608338B2 (en) 2023-03-21
EP3868761A1 (de) 2021-08-25
BR122019005502B1 (pt) 2024-02-27
EP3868761B1 (de) 2023-03-01
US20230203034A1 (en) 2023-06-29
IL271494B (en) 2021-05-31
CN107889488A (zh) 2018-04-06
RS59139B1 (sr) 2019-09-30

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