JP6544808B2 - 突然変異免疫グロブリン結合ポリペプチド - Google Patents

突然変異免疫グロブリン結合ポリペプチド Download PDF

Info

Publication number
JP6544808B2
JP6544808B2 JP2016525329A JP2016525329A JP6544808B2 JP 6544808 B2 JP6544808 B2 JP 6544808B2 JP 2016525329 A JP2016525329 A JP 2016525329A JP 2016525329 A JP2016525329 A JP 2016525329A JP 6544808 B2 JP6544808 B2 JP 6544808B2
Authority
JP
Japan
Prior art keywords
seq
polypeptide
protein
multimer
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016525329A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016523959A5 (OSRAM
JP2016523959A (ja
Inventor
ロドリゴ，グスタフ
アンデル，マッツ
バウレン，ゴラン
ビョルクマン，トマス
Original Assignee
ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ filed Critical ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ
Publication of JP2016523959A publication Critical patent/JP2016523959A/ja
Publication of JP2016523959A5 publication Critical patent/JP2016523959A5/ja
Application granted granted Critical
Publication of JP6544808B2 publication Critical patent/JP6544808B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2016525329A 2013-07-10 2014-07-08 突然変異免疫グロブリン結合ポリペプチド Active JP6544808B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1350860-1 2013-07-10
SE1350859 2013-07-10
SE1350860 2013-07-10
SE1350859-3 2013-07-10
PCT/SE2014/050872 WO2015005859A1 (en) 2013-07-10 2014-07-08 Mutated immunoglobulin-binding polypeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019109474A Division JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

Publications (3)

Publication Number Publication Date
JP2016523959A JP2016523959A (ja) 2016-08-12
JP2016523959A5 JP2016523959A5 (OSRAM) 2017-08-17
JP6544808B2 true JP6544808B2 (ja) 2019-07-17

Family

ID=52280382

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016525329A Active JP6544808B2 (ja) 2013-07-10 2014-07-08 突然変異免疫グロブリン結合ポリペプチド
JP2016525330A Active JP6544809B2 (ja) 2013-07-10 2014-07-10 突然変異免疫グロブリン結合ポリペプチド
JP2019109474A Active JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016525330A Active JP6544809B2 (ja) 2013-07-10 2014-07-10 突然変異免疫グロブリン結合ポリペプチド
JP2019109474A Active JP6862008B2 (ja) 2013-07-10 2019-06-12 突然変異免疫グロブリン結合ポリペプチド

Country Status (5)

Country Link
US (5) US9896486B2 (OSRAM)
EP (2) EP3019520B1 (OSRAM)
JP (3) JP6544808B2 (OSRAM)
CN (3) CN111848755A (OSRAM)
WO (2) WO2015005859A1 (OSRAM)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US9896486B2 (en) 2013-07-10 2018-02-20 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
NZ758065A (en) 2013-10-22 2022-08-26 Nuvoda Llc Reduction of substances in contaminated fluids using a naturally occurring biological growth media
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3276002B1 (en) * 2015-03-26 2020-04-29 JSR Corporation Immunoglobulin-binding protein and affinity carrier using same
WO2016167143A1 (ja) 2015-04-13 2016-10-20 富士フイルム株式会社 短鎖ペプチド固定化担体の製造方法および短鎖ペプチド固定化担体
JPWO2017014261A1 (ja) * 2015-07-22 2018-04-26 株式会社カネカ 抗体様タンパク質の精製方法
WO2017014257A1 (ja) * 2015-07-22 2017-01-26 株式会社カネカ 酸性ｐＨ領域での抗体結合能が低下した抗体結合性タンパク質
WO2017018437A1 (ja) * 2015-07-28 2017-02-02 Jsr株式会社 アフィニティー担体およびイムノグロブリンを単離する方法
JPWO2017022672A1 (ja) * 2015-07-31 2018-07-05 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
WO2017022759A1 (ja) * 2015-08-04 2017-02-09 株式会社カネカ 免疫グロブリン結合性改変型タンパク質
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
ES2909833T3 (es) 2016-05-11 2022-05-10 Cytiva Bioprocess R & D Ab Método de limpieza y/o desinfección de una matriz de separación
EP3455243B1 (en) * 2016-05-11 2021-03-24 Cytiva BioProcess R&D AB Separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) * 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
CN109219613B (zh) * 2016-05-11 2022-09-23 思拓凡生物工艺研发有限公司 分离方法
JP7122974B2 (ja) * 2016-05-11 2022-08-22 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 変異免疫グロブリン結合ポリペプチド
US11708390B2 (en) 2016-05-11 2023-07-25 Cytiva Bioprocess R&D Ab Method of storing a separation matrix
DK3497117T5 (da) 2016-08-11 2024-09-02 Navigo Proteins Gmbh Nye alkalisk stabile immunglobulin-bindende proteiner
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
CN110799521A (zh) * 2017-02-15 2020-02-14 拜奥普罗塞亚科技有限责任公司 具有温和洗脱pH的亲和色谱配体
GB201703116D0 (en) * 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3592759A1 (en) * 2017-03-07 2020-01-15 JMVA Biotech AB Modified adsorptive surfaces
GB201708277D0 (en) 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
CN111132994B (zh) * 2017-08-07 2024-05-31 瑞普利金公司 在c末端螺旋区中具有半胱氨酸的fc结合蛋白
EP3521304B9 (en) 2018-02-01 2023-10-04 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP3546476A1 (en) * 2018-03-26 2019-10-02 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
JP7335881B2 (ja) * 2018-08-24 2023-08-30 Jsr株式会社 イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
CN111057153B (zh) 2019-12-06 2021-09-07 广州康盛生物科技股份有限公司 一种免疫球蛋白结合蛋白及其制备方法和应用
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN111732642B (zh) * 2020-07-30 2020-12-04 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
CN116391122A (zh) 2020-09-24 2023-07-04 沃特世科技公司 用于反应性分子分离的色谱硬件改进
KR20230112616A (ko) 2020-10-13 2023-07-27 아비타이드 엘엘씨 3중-나선 번들 단백질들의 친화성 리간드 라이브러리 및 이의 용도
WO2022138718A1 (ja) * 2020-12-22 2022-06-30 プロテノバ株式会社 イムノグロブリン結合ポリペプチド
WO2022178396A1 (en) 2021-02-19 2022-08-25 Avitide LLC Aav2 affinity agents
GB202113626D0 (en) 2021-09-24 2021-11-10 Cytiva Bioprocess R & D Ab FC binding polypeptides
CN114149495A (zh) * 2021-12-17 2022-03-08 博格隆(上海)生物技术有限公司 突变的蛋白a结构域c及其应用
CN114315996B (zh) * 2021-12-31 2023-01-17 博格隆(浙江)生物技术有限公司 一种重组ProteinA蛋白及亲和层析介质的制备方法
CN114409748A (zh) * 2022-01-28 2022-04-29 博格隆(浙江)生物技术有限公司 蛋白a的b结构域和z结构域突变体及其应用
GB202203478D0 (en) 2022-03-14 2022-04-27 Cytiva Bioprocess R & D Ab Vh3 binding polypeptides
CN115850408A (zh) * 2022-09-01 2023-03-28 西安蓝晓科技新材料股份有限公司 一种多肽、融合型多聚体蛋白质及其用途
CN117700501A (zh) * 2022-09-13 2024-03-15 普米斯生物技术(珠海)有限公司 免疫球蛋白结合蛋白及其应用
CN116217680B (zh) * 2023-01-10 2024-02-02 珠海冀百康生物科技有限公司 碱稳定性高的免疫球蛋白结合蛋白及其应用
CN116333056A (zh) * 2023-02-09 2023-06-27 西宝生物科技（上海）股份有限公司 一种高结合容量的耐碱重组Protein A及其制备方法和应用
CN119708176A (zh) * 2024-12-05 2025-03-28 武汉瑞法医疗器械有限公司 一种多肽、多聚体及其在免疫球蛋白亲和配体中的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8505922D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
SE9901379D0 (sv) * 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
US6602977B1 (en) * 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
SE0200943D0 (sv) 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
CA2531238C (en) * 2003-07-04 2015-02-24 Affibody Ab Polypeptides having binding affinity for her2
JP2006304633A (ja) 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
US20100015044A1 (en) * 2005-08-03 2010-01-21 Robert Qiu Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases
WO2007097361A1 (ja) 2006-02-21 2007-08-30 Protenova Co., Ltd. イムノグロブリン親和性リガンド
JP5345539B2 (ja) 2006-09-29 2013-11-20 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー 抗体単離のためのスタフィロコッカスアウレウス由来のドメインｃを含むクロマトグラフィーリガンド
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
SG162687A1 (en) * 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
JP2012515160A (ja) * 2009-01-12 2012-07-05 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ アフィニティークロマトグラフィーマトリックス
WO2010110288A1 (ja) 2009-03-24 2010-09-30 株式会社カネカ 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド
SMT202000246T1 (it) * 2009-04-03 2020-07-08 Univ Chicago Composizioni e metodi relativi a varianti della proteina a (spa)
CN103228328A (zh) * 2010-11-29 2013-07-31 通用电气健康护理生物科学股份公司 亲和色谱基质
EP2654914B1 (en) * 2010-12-20 2018-05-30 GE Healthcare BioProcess R&D AB Affinity chromatography matrix
US9051375B2 (en) * 2010-12-21 2015-06-09 The University Of Western Ontario Alkali-resistant variants of protein A and their use in affinity chromatography
CN103270044B (zh) 2010-12-21 2016-03-09 Jsr株式会社 亲和色谱用载体和分离免疫球蛋白的方法
JP5812303B2 (ja) 2011-06-03 2015-11-11 国立研究開発法人産業技術総合研究所 酸性域での親和性が低下したプロテインａ変異型タンパク質及び抗体捕捉剤
SG10201604554WA (en) * 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
DE102013212062B4 (de) 2013-06-25 2017-05-11 Pantrac Gmbh Vorrichtung zur Ableitung von Erdungsströmen, insbesondere in Windkraftanlagen
US9454196B2 (en) * 2013-06-27 2016-09-27 Apple Inc. Active peak power management of a high performance embedded microprocessor cluster
US9896486B2 (en) 2013-07-10 2018-02-20 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides

Also Published As

Publication number Publication date
JP6862008B2 (ja) 2021-04-21
CN105377880A (zh) 2016-03-02
JP2016525100A (ja) 2016-08-22
CN111848755A (zh) 2020-10-30
CN105377881B (zh) 2020-08-07
US10308690B2 (en) 2019-06-04
US20160159857A1 (en) 2016-06-09
US20160159855A1 (en) 2016-06-09
CN105377881A (zh) 2016-03-02
US20160207966A1 (en) 2016-07-21
EP3019520A4 (en) 2017-03-08
US11136359B2 (en) 2021-10-05
CN105377880B (zh) 2020-08-07
EP3019519B1 (en) 2019-04-03
WO2015005859A1 (en) 2015-01-15
JP2019165747A (ja) 2019-10-03
US10112980B2 (en) 2018-10-30
EP3019520B1 (en) 2019-12-11
US9896486B2 (en) 2018-02-20
EP3019519A4 (en) 2017-03-08
US20170320922A1 (en) 2017-11-09
US20180244729A1 (en) 2018-08-30
JP2016523959A (ja) 2016-08-12
JP6544809B2 (ja) 2019-07-17
EP3019520A1 (en) 2016-05-18
EP3019519A1 (en) 2016-05-18
US9663558B2 (en) 2017-05-30
WO2015005862A1 (en) 2015-01-15

Similar Documents

Publication Publication Date Title
JP6544808B2 (ja) 突然変異免疫グロブリン結合ポリペプチド
US12221492B2 (en) Mutated immunoglobulin-binding polypeptides
JP7122974B2 (ja) 変異免疫グロブリン結合ポリペプチド
JP2019521959A (ja) 分離マトリックスを洗浄および／または消毒する方法
JP2023550778A (ja) 分離基材

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170705

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170705

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20171110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20171110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20180119

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20180221

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180427

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180508

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180806

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181009

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181212

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190514

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20190521

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190613

R150 Certificate of patent or registration of utility model

Ref document number: 6544808

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250