JP6512759B2 - 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 - Google Patents
羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 Download PDFInfo
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- JP6512759B2 JP6512759B2 JP2014130142A JP2014130142A JP6512759B2 JP 6512759 B2 JP6512759 B2 JP 6512759B2 JP 2014130142 A JP2014130142 A JP 2014130142A JP 2014130142 A JP2014130142 A JP 2014130142A JP 6512759 B2 JP6512759 B2 JP 6512759B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0669—Bone marrow stromal cells; Whole bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014130142A JP6512759B2 (ja) | 2013-08-19 | 2014-06-25 | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
| CN201480046241.8A CN105765060B (zh) | 2013-08-19 | 2014-08-18 | 羊膜间充质系细胞组合物的制造方法和冷冻保存方法、以及治疗剂 |
| EP14837352.5A EP3037523B1 (en) | 2013-08-19 | 2014-08-18 | Production method and cryopreservation method for amniotic mesenchymal cell composition, and therapeutic agent |
| US14/912,662 US10441611B2 (en) | 2013-08-19 | 2014-08-18 | Method for producing amniotic mesenchymal stromal cell composition, method for cryopreserving the same, and therapeutic agent |
| PCT/JP2014/071546 WO2015025810A1 (ja) | 2013-08-19 | 2014-08-18 | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
| US16/508,463 US11389486B2 (en) | 2013-08-19 | 2019-07-11 | Method for producing amniotic mesenchymal stromal cell composition, method for cryopreserving the same, and therapeutic agent |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013170008 | 2013-08-19 | ||
| JP2013170008 | 2013-08-19 | ||
| JP2014130142A JP6512759B2 (ja) | 2013-08-19 | 2014-06-25 | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019038143A Division JP6754459B2 (ja) | 2013-08-19 | 2019-03-04 | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015061520A JP2015061520A (ja) | 2015-04-02 |
| JP2015061520A5 JP2015061520A5 (enExample) | 2017-09-14 |
| JP6512759B2 true JP6512759B2 (ja) | 2019-05-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130142A Active JP6512759B2 (ja) | 2013-08-19 | 2014-06-25 | 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10441611B2 (enExample) |
| EP (1) | EP3037523B1 (enExample) |
| JP (1) | JP6512759B2 (enExample) |
| CN (1) | CN105765060B (enExample) |
| WO (1) | WO2015025810A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016181885A1 (ja) * | 2015-05-14 | 2016-11-17 | 株式会社再生医療推進機構 | 凍結間葉系細胞の製造方法、及び、移植用治療材の製造方法 |
| WO2017073656A1 (ja) * | 2015-10-27 | 2017-05-04 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団の製造方法、間葉系幹細胞、細胞集団、並びに医薬組成物 |
| AU2017215955B2 (en) * | 2016-02-01 | 2020-01-23 | GC Cell Corporation | Medium composition for cryopreservation of cell and use thereof |
| EP3564356A4 (en) * | 2016-11-04 | 2020-05-06 | The University Of Tokyo | SOLUTION FOR CRYOPRESERVATION, CRYOGENIZATION PRODUCT, AND METHOD FOR CRYOPRESERVATION OF ANIMAL CELLS OR ANIMAL TISSUES |
| US11401502B2 (en) | 2016-11-15 | 2022-08-02 | Kaneka Corporation | Cell population comprising mesenchymal stem cells derived from fetal appendage, method for producing the same, and pharmaceutical composition |
| JP7140752B2 (ja) | 2017-04-03 | 2022-09-21 | 株式会社カネカ | 胎児付属物由来接着細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| JP7102397B2 (ja) * | 2017-04-03 | 2022-07-19 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| JP7152389B2 (ja) * | 2017-04-03 | 2022-10-12 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団とその製造方法、間葉系幹細胞及び医薬組成物 |
| CN106967675A (zh) * | 2017-05-31 | 2017-07-21 | 东莞市保莱生物科技有限公司 | 一种从胎盘中分离提取造血干细胞的方法 |
| WO2019059279A1 (ja) * | 2017-09-20 | 2019-03-28 | 株式会社カネカ | 細胞懸濁液を調製するためのデバイス、システム及び方法 |
| EP3750987A4 (en) * | 2017-12-28 | 2021-11-10 | Kaneka Corporation | CELL POPULATION INCLUDING ADHESIVE STEM CELLS, ITS PRODUCTION PROCESS, AND PHARMACEUTICAL COMPOSITION |
| CN111566205B (zh) * | 2017-12-28 | 2024-10-29 | 株式会社钟化 | 包含贴壁性干细胞的细胞群、其制备方法、以及医药组合物 |
| CN108904533A (zh) * | 2018-07-04 | 2018-11-30 | 卡替(上海)生物技术股份有限公司 | 牙髓间充质干细胞在制备肝硬化治疗药物中的用途 |
| WO2020184350A1 (ja) | 2019-03-08 | 2020-09-17 | 株式会社カネカ | 多能性幹細胞の大量培養 |
| WO2020251020A1 (ja) * | 2019-06-14 | 2020-12-17 | 株式会社カネカ | 間葉系細胞を含む細胞集団、それを含む医薬組成物、及び、その製造方法 |
| US20230338428A1 (en) * | 2020-09-08 | 2023-10-26 | Amit Patel | Allogenic umbilical cord stem cells for treating severe respiratory conditions |
| JP7672647B2 (ja) * | 2021-02-05 | 2025-05-08 | 株式会社カネカ | 間葉系幹細胞を含む細胞集団を含有する軟部組織再生用医薬組成物 |
| JPWO2022203022A1 (enExample) * | 2021-03-26 | 2022-09-29 | ||
| CN113456891B (zh) * | 2021-06-16 | 2022-05-17 | 成都微沃科技有限公司 | 一种从细胞层中提取细胞外基质层的方法 |
| CN114097768A (zh) * | 2021-11-24 | 2022-03-01 | 李敬 | 一种骨髓干细胞用保护液及其制备方法和应用 |
| CN120400046B (zh) * | 2025-07-03 | 2025-10-17 | 济南万泉生物技术有限公司 | 一种羊膜基质细胞培养体系、细胞培养方法及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69933579D1 (de) * | 1998-11-09 | 2006-11-23 | Consorzio Per La Gestione Del | Serum-freies medium für chondrozyt-ähnliche zellen |
| JP2000201672A (ja) * | 1999-01-11 | 2000-07-25 | Asahi Medical Co Ltd | 有核細胞の凍結保存用組成物 |
| AU2002363659B2 (en) | 2001-11-15 | 2008-09-25 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US7176022B2 (en) * | 2002-12-20 | 2007-02-13 | Cell Genesys, Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
| CN101501185A (zh) * | 2006-06-09 | 2009-08-05 | 人类起源公司 | 胎盘巢(placental niche)及其培养干细胞的用途 |
| PT2120977E (pt) * | 2007-02-12 | 2013-09-16 | Anthrogenesis Corp | Tratamento de doenças inflamatórias utilizando células estaminais da placenta |
| EP2132299A4 (en) | 2007-03-01 | 2010-03-10 | Cryo Cell Int | OBTAINING, ISOLATING, AND CRYOKON SUSPENSION OF ENDOMETRY / MENSTRUATION CELLS |
| EP2014767A1 (en) * | 2007-06-15 | 2009-01-14 | Centro di Ricerca E. Menni | T cell immunomodulation by placenta cell preparations |
| CA2714777A1 (en) * | 2007-10-31 | 2009-05-07 | Cryo-Cell International, Inc. | Methods for co-culturing cord blood derived cells with menstrual stem cells |
| KR20220025141A (ko) * | 2008-08-20 | 2022-03-03 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| NZ592726A (en) | 2008-11-19 | 2012-12-21 | Anthrogenesis Corp | Amnion derived adherent cells |
| CN102482641A (zh) * | 2009-08-19 | 2012-05-30 | 宝生物工程株式会社 | 细胞保存方法 |
| EP3351624B1 (en) | 2010-02-18 | 2022-09-14 | Osiris Therapeutics, Inc. | Methods of manufacture of therapeutic products comprising vitalized placental dispersions |
| CN104470529A (zh) * | 2011-07-15 | 2015-03-25 | 人类起源公司 | 利用羊膜来源的贴壁细胞治疗辐射损伤 |
-
2014
- 2014-06-25 JP JP2014130142A patent/JP6512759B2/ja active Active
- 2014-08-18 EP EP14837352.5A patent/EP3037523B1/en active Active
- 2014-08-18 WO PCT/JP2014/071546 patent/WO2015025810A1/ja not_active Ceased
- 2014-08-18 CN CN201480046241.8A patent/CN105765060B/zh active Active
- 2014-08-18 US US14/912,662 patent/US10441611B2/en active Active
-
2019
- 2019-07-11 US US16/508,463 patent/US11389486B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3037523A1 (en) | 2016-06-29 |
| US11389486B2 (en) | 2022-07-19 |
| CN105765060B (zh) | 2020-04-28 |
| US20160228474A1 (en) | 2016-08-11 |
| US10441611B2 (en) | 2019-10-15 |
| US20190343892A1 (en) | 2019-11-14 |
| EP3037523A4 (en) | 2017-01-25 |
| JP2015061520A (ja) | 2015-04-02 |
| CN105765060A (zh) | 2016-07-13 |
| EP3037523B1 (en) | 2020-08-12 |
| WO2015025810A1 (ja) | 2015-02-26 |
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