JP6470286B2 - ラミニンの角膜内皮細胞培養への応用 - Google Patents

ラミニンの角膜内皮細胞培養への応用 Download PDF

Info

Publication number
JP6470286B2
JP6470286B2 JP2016535065A JP2016535065A JP6470286B2 JP 6470286 B2 JP6470286 B2 JP 6470286B2 JP 2016535065 A JP2016535065 A JP 2016535065A JP 2016535065 A JP2016535065 A JP 2016535065A JP 6470286 B2 JP6470286 B2 JP 6470286B2
Authority
JP
Japan
Prior art keywords
laminin
chain
corneal endothelial
seq
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016535065A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016539641A5 (enExample
JP2016539641A (ja
Inventor
範子 小泉
範子 小泉
直毅 奥村
直毅 奥村
木下　茂
茂 木下
エー． クルーゼ フリードリッヒ
エー． クルーゼ フリードリッヒ
シュロッツァ−シュレハルト ウルズラ
シュロッツァ−シュレハルト ウルズラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
Senju Pharmaceutical Co Ltd
Doshisha Co Ltd
Original Assignee
KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
Senju Pharmaceutical Co Ltd
Doshisha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Senju Pharmaceutical Co Ltd, Doshisha Co Ltd filed Critical KYOTO PREFECTURAL UNIVERSITY OF MEDICINE
Publication of JP2016539641A publication Critical patent/JP2016539641A/ja
Publication of JP2016539641A5 publication Critical patent/JP2016539641A5/ja
Application granted granted Critical
Publication of JP6470286B2 publication Critical patent/JP6470286B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016535065A 2013-11-27 2014-11-26 ラミニンの角膜内皮細胞培養への応用 Active JP6470286B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013244972 2013-11-27
JP2013244972 2013-11-27
PCT/JP2014/081917 WO2015080297A1 (en) 2013-11-27 2014-11-26 Application of laminin to corneal endothelial cell culture

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019006098A Division JP2019054828A (ja) 2013-11-27 2019-01-17 ラミニンの角膜内皮細胞培養への応用

Publications (3)

Publication Number Publication Date
JP2016539641A JP2016539641A (ja) 2016-12-22
JP2016539641A5 JP2016539641A5 (enExample) 2017-12-07
JP6470286B2 true JP6470286B2 (ja) 2019-02-13

Family

ID=52432880

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016535065A Active JP6470286B2 (ja) 2013-11-27 2014-11-26 ラミニンの角膜内皮細胞培養への応用
JP2019006098A Withdrawn JP2019054828A (ja) 2013-11-27 2019-01-17 ラミニンの角膜内皮細胞培養への応用
JP2020098407A Pending JP2020188778A (ja) 2013-11-27 2020-06-05 ラミニンの角膜内皮細胞培養への応用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019006098A Withdrawn JP2019054828A (ja) 2013-11-27 2019-01-17 ラミニンの角膜内皮細胞培養への応用
JP2020098407A Pending JP2020188778A (ja) 2013-11-27 2020-06-05 ラミニンの角膜内皮細胞培養への応用

Country Status (10)

Country Link
US (1) US11624053B2 (enExample)
EP (1) EP3074508B1 (enExample)
JP (3) JP6470286B2 (enExample)
CN (1) CN105814195A (enExample)
BR (1) BR112016011096A2 (enExample)
CA (1) CA2931280A1 (enExample)
ES (1) ES2763433T3 (enExample)
MX (1) MX2016006915A (enExample)
RU (1) RU2704984C1 (enExample)
WO (1) WO2015080297A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2716200T3 (es) 2011-12-06 2019-06-11 Astellas Inst For Regenerative Medicine Método de diferenciación dirigida que produce células endoteliales corneales
CN113559246A (zh) 2014-10-31 2021-10-29 京都府公立大学法人 使用层粘连蛋白的新的角膜的治疗
WO2016067629A1 (ja) 2014-10-31 2016-05-06 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
JP6849957B2 (ja) * 2015-11-10 2021-03-31 国立大学法人京都大学 ラミニンフラグメント含有培地を用いる細胞培養方法
WO2017082026A1 (ja) * 2015-11-10 2017-05-18 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
MY192056A (en) * 2017-01-31 2022-07-25 Univ Osaka Method for controlling differentiation of pluripotent stem cells
WO2019079809A1 (en) * 2017-10-22 2019-04-25 The Johns Hopkins University BIOMIMETIC PLATFORMS FOR MODELING VASCULAR PHYSIOPATHOLOGY, DIAGNOSIS AND THERAPY
WO2019102593A1 (ja) * 2017-11-24 2019-05-31 株式会社Ihi 細胞培養装置
JP6664755B1 (ja) * 2018-10-02 2020-03-13 学校法人同志社 角膜内皮細胞を保存するための方法および容器
AU2019352309A1 (en) * 2018-10-02 2021-03-11 The Doshisha Method and vessel for preserving corneal endothelial cells
EP3939663A4 (en) * 2019-03-12 2022-05-04 Nissan Chemical Corporation THERAPEUTIC AGENT FOR CORNEAL DISEASES
JP2023025311A (ja) * 2020-02-05 2023-02-22 味の素株式会社 タンパク質の製造方法
CN112522179A (zh) * 2020-12-23 2021-03-19 江苏艾尔康生物医药科技有限公司 一种角膜内皮细胞的分离培养方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
JP3421217B2 (ja) 1995-11-20 2003-06-30 麒麟麦酒株式会社 Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
AU3300297A (en) 1996-06-05 1998-01-07 General Hospital Corporation, The Laminin-5 and the formation of basement membrane structure
FR2765781B1 (fr) 1997-07-08 1999-09-24 Gioia Bruno Di Procede de fabrication d'un accessoire de mode, dispositif pour la mise en oeuvre du procede et accessoire de mode ainsi realise
US6042262A (en) 1997-07-29 2000-03-28 Stryker Technologies Corportion Apparatus for storing, mixing, and dispensing two-component bone cement
US6693169B1 (en) 1998-10-13 2004-02-17 The General Hospital Corporation Laminin 5, 13 and 14 and uses thereof
JP2002542824A (ja) 1999-04-30 2002-12-17 バイオストラタム インコーポレイテッド 組換えラミニン５
US6635616B2 (en) 2000-05-01 2003-10-21 The General Hospital Corporation Laminin 15
US6933273B2 (en) 2000-12-21 2005-08-23 Karl Tryggvason Isolated laminin 10
WO2002076977A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
HN2002000067A (es) 2001-03-23 2003-10-24 Bayer Healthcare Llc Inhibidores de la rho - quinasa.
WO2002083175A1 (en) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Visual function improving agents
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
JP4505228B2 (ja) 2002-01-10 2010-07-21 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト Ｒｈｏ−キナーゼ阻害剤
ES2298497T3 (es) 2002-01-23 2008-05-16 Bayer Pharmaceuticals Corporation Inhibidores de quinasa rho.
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
AU2003211971A1 (en) * 2002-04-30 2003-11-17 Amniotec Inc. Corneal endothelium-like sheet and method of constructing the same
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
CA2400996A1 (en) 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
EP1644365A2 (en) 2003-07-02 2006-04-12 Biofocus Discovery Ltd Pyrazine and pyridine derivatives as rho kinase inhibitors
US20050182061A1 (en) 2003-10-02 2005-08-18 Jeremy Green Phthalimide compounds useful as protein kinase inhibitors
EP1670466A4 (en) 2003-10-06 2007-04-25 Glaxo Group Ltd PREPARATION OF 1,6,7-TRISUBSTITUTED AZABENIC ZIMIDAZOLES AS KINASE-INHIBITORS
WO2005037197A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
JP2007507547A (ja) 2003-10-06 2007-03-29 グラクソ　グループ　リミテッド キナーゼ阻害剤としての１，７−二置換アザベンゾイミダゾールの調製
CN100560142C (zh) 2003-10-10 2009-11-18 细胞生物工程公司 用于在生物聚合物上培养角膜内皮细胞和相关细胞以及产生人工角膜移植物的方法和组合物
AU2004281694B2 (en) 2003-10-10 2012-05-03 Cellular Bioengineering, Inc. Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants
DK1675944T3 (da) 2003-10-10 2011-02-28 Ge Ming Lui Humane corneale endotelceller og fremgangsmåder til opnåelse og dyrkning af celler til corneal celletransplantation
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
MX375065B (es) 2004-01-23 2025-03-06 Harvard College Composiciones para usarse en el tratamiento de enfermedades degenerativas de la retina.
EP1737479B1 (en) 2004-02-12 2014-12-17 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Therapeutic administration of the scrambled anti-angiogenic peptide C16Y
EP1720874A4 (en) 2004-02-24 2010-03-03 Bioaxone Therapeutique Inc 4-SUBSTITUTED PIPERIDINE DERIVATIVES
RU2006138621A (ru) 2004-04-02 2008-05-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Азаиндолы, полезные в качестве ингибиторов rock и других протеинкиназ
WO2006057270A1 (ja) 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素３環化合物
AU2006285915B2 (en) 2005-08-30 2011-02-24 Asahi Kasei Pharma Corporation Sulfonamide compound
US10052411B2 (en) 2006-01-19 2018-08-21 Senju Pharmaceutical Co., Ltd. Methods of treating corneal related diseases by corneal endothelial preparation which enables cells to grow in vivo
US20090175835A1 (en) 2006-02-07 2009-07-09 Korea Institute Of Radiological & Medical Sciences Composition for treating damage of central or peripheral nerve system
WO2007127172A2 (en) 2006-04-27 2007-11-08 The Trustees Of Columbia University In The City Of New York Layered bio-adhesive compositions and uses thereof
US8951799B2 (en) 2007-01-04 2015-02-10 Biolamina Ab Composition and method for enabling proliferation of pluripotent stem cells
JP5657252B2 (ja) * 2007-08-29 2015-01-21 千寿製薬株式会社 角膜内皮細胞接着促進剤
US20090306772A1 (en) 2008-04-18 2009-12-10 The Regents Of The University Of California Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane
US8680182B2 (en) 2009-06-04 2014-03-25 Clemson University Research Foundation Methods for promoting the revascularization and reenervation of CNS lesions
WO2010140464A1 (ja) 2009-06-05 2010-12-09 国立大学法人 熊本大学 細胞の分化誘導方法
JP5590646B2 (ja) * 2009-10-08 2014-09-17 国立大学法人大阪大学 ヒト多能性幹細胞用培養基材およびその利用
RU2418067C1 (ru) 2009-12-03 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ культивирования клеток
WO2011080984A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
JP5990531B2 (ja) 2010-12-17 2016-09-14 ビオラミナ アーベー 組換えラミニン−５２１
JPWO2012173207A1 (ja) 2011-06-14 2015-02-23 独立行政法人理化学研究所 網膜細胞への分化誘導方法
JP5761827B2 (ja) * 2011-07-15 2015-08-12 国立大学法人大阪大学 角膜内皮細胞の調製方法
JPWO2013047763A1 (ja) 2011-09-29 2015-03-30 オリエンタル酵母工業株式会社 ラミニン５１１を含んだ系で哺乳類細胞を培養する方法
PT2780022T (pt) 2011-11-14 2019-07-16 Astellas Inst For Regenerative Medicine Preparações farmacêuticas de células epr humanas e suas utilizações
KR102111936B1 (ko) 2011-11-25 2020-05-18 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
JP5985207B2 (ja) 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
ES2716200T3 (es) * 2011-12-06 2019-06-11 Astellas Inst For Regenerative Medicine Método de diferenciación dirigida que produce células endoteliales corneales
US9351914B2 (en) 2012-03-25 2016-05-31 The Board Of Trustees Of The Leland Stanford Junior University Methods for modulating hair growth using truncated laminin-511
TR201807259T4 (tr) 2012-12-03 2018-06-21 Biolamina Ab Rpe hücreleri üretim yöntemleri.
SG10201802879PA (en) 2013-10-09 2018-05-30 Healios Kk Method for purification of retinal pigment epithelial cells
WO2016067629A1 (ja) 2014-10-31 2016-05-06 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
CN113559246A (zh) 2014-10-31 2021-10-29 京都府公立大学法人 使用层粘连蛋白的新的角膜的治疗
EP3813853A4 (en) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. DELIVERY COMPOSITIONS AND METHODS OF USE

Also Published As

Publication number Publication date
EP3074508B1 (en) 2019-11-06
ES2763433T3 (es) 2020-05-28
JP2020188778A (ja) 2020-11-26
MX2016006915A (es) 2017-01-23
RU2704984C1 (ru) 2019-11-01
US20170002318A1 (en) 2017-01-05
CN105814195A (zh) 2016-07-27
US11624053B2 (en) 2023-04-11
RU2016125225A (ru) 2018-01-09
EP3074508A1 (en) 2016-10-05
CA2931280A1 (en) 2015-06-04
JP2019054828A (ja) 2019-04-11
JP2016539641A (ja) 2016-12-22
BR112016011096A2 (pt) 2017-09-19
WO2015080297A1 (en) 2015-06-04

Similar Documents

Publication Publication Date Title
JP6470286B2 (ja) ラミニンの角膜内皮細胞培養への応用
JP2022097730A (ja) ラミニンによる角膜の新規治療
Yuan et al. Injectable GelMA cryogel microspheres for modularized cell delivery and potential vascularized bone regeneration
Yang et al. Potential of human dental stem cells in repairing the complete transection of rat spinal cord
Martins-Green Dynamics of cell-ECM interactions
JP6770435B2 (ja) ラミニンによる網膜および神経の新規治療
Lee et al. Nidogen is a prosurvival and promigratory factor for adult Schwann cells
WO2015015655A1 (ja) フックス角膜内皮ジストロフィ不死化細胞株およびその作製法
Hazra et al. In vitro profiling of the extracellular matrix and integrins expressed by human corneal endothelial cells cultured on silk fibroin-based matrices
Nakamura et al. Promotion of angiogenesis by an artificial extracellular matrix protein containing the laminin-1-derived IKVAV sequence
JP5882198B2 (ja) ラミニン５を含んだ系で細胞を培養する方法
Lingling et al. Recombinant human bone morphogenetic protein-7 enhances bone formation ability of jaw bone defect using human umbilical cord mesenchymal stem cells combined with nano-hydroxyapatite/collagen/poly (L-lactide)
Nguyen Determining the Effects of Recombinant Lysyl Oxidase on Tendon Mechanical Properties and Cell Behaviors
WO2018230712A1 (ja) ＴＧＦ－β阻害剤の新規スクリーニング法
Chirila et al. Reconstruction of the ocular surface using biomaterials
Amr Prerequisites for mesenchymal stem cell transplantation in spinal cord injury
Sueblinvong et al. Stem Cells and Cell–Matrix Interactions in Lung
Baker Robert N. Kent III1, Maggie E. Jewett1, Trevor P. Buck1, Mohamed Said1, LeeAnn A. Hold3, Eileen A. Crawford, MD3, Megan L. Killian, PhD3, Adam C. Abraham, PhD3, Alice H. Huang, PhD4, Brendon M. Baker, PhD1, 2

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160627

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171023

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171023

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180827

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181023

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181226

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190117

R150 Certificate of patent or registration of utility model

Ref document number: 6470286

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313117

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D04

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250