BR112016011096A2 - Aplicação de laminina à cultura de célula endotelial da córnea - Google Patents

Aplicação de laminina à cultura de célula endotelial da córnea

Info

Publication number
BR112016011096A2
BR112016011096A2 BR112016011096A BR112016011096A BR112016011096A2 BR 112016011096 A2 BR112016011096 A2 BR 112016011096A2 BR 112016011096 A BR112016011096 A BR 112016011096A BR 112016011096 A BR112016011096 A BR 112016011096A BR 112016011096 A2 BR112016011096 A2 BR 112016011096A2
Authority
BR
Brazil
Prior art keywords
corneal endothelial
present
laminin
cell culture
endothelial cells
Prior art date
Application number
BR112016011096A
Other languages
English (en)
Portuguese (pt)
Inventor
Koizumi Noriko
Okumura Naoki
Kinoshita Shigeru
E Kruse Friedrich
SCHLOETZER-SCHREHARDT Ursula
Original Assignee
Kyoto Prefectural Public Univ Corp
The Doshisha
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Prefectural Public Univ Corp, The Doshisha, Senju Pharma Co filed Critical Kyoto Prefectural Public Univ Corp
Publication of BR112016011096A2 publication Critical patent/BR112016011096A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112016011096A 2013-11-27 2014-11-26 Aplicação de laminina à cultura de célula endotelial da córnea BR112016011096A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013244972 2013-11-27
PCT/JP2014/081917 WO2015080297A1 (en) 2013-11-27 2014-11-26 Application of laminin to corneal endothelial cell culture

Publications (1)

Publication Number Publication Date
BR112016011096A2 true BR112016011096A2 (pt) 2017-09-19

Family

ID=52432880

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016011096A BR112016011096A2 (pt) 2013-11-27 2014-11-26 Aplicação de laminina à cultura de célula endotelial da córnea

Country Status (10)

Country Link
US (1) US11624053B2 (enExample)
EP (1) EP3074508B1 (enExample)
JP (3) JP6470286B2 (enExample)
CN (1) CN105814195A (enExample)
BR (1) BR112016011096A2 (enExample)
CA (1) CA2931280A1 (enExample)
ES (1) ES2763433T3 (enExample)
MX (1) MX2016006915A (enExample)
RU (1) RU2704984C1 (enExample)
WO (1) WO2015080297A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2788472T3 (pl) 2011-12-06 2019-06-28 Astellas Institute For Regenerative Medicine Sposób ukierunkowanego różnicowania z wytwarzaniem komórek śródbłonka rogówki
EP3213761B1 (en) 2014-10-31 2021-05-19 Kyoto Prefectural Public University Corporation Novel treatment of retina using laminin
MX387839B (es) 2014-10-31 2025-03-04 Senju Pharma Co Laminina para usarse en el tratamiento de una enfermedad, un trastorno o una afección de un endotelio de córnea.
JP6849957B2 (ja) * 2015-11-10 2021-03-31 国立大学法人京都大学 ラミニンフラグメント含有培地を用いる細胞培養方法
JP6605618B2 (ja) 2015-11-10 2019-11-20 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
WO2018143312A1 (ja) * 2017-01-31 2018-08-09 国立大学法人大阪大学 多能性幹細胞の分化制御方法
US20210372995A1 (en) * 2017-10-22 2021-12-02 The Johns Hopkins University Biomimetic platforms to model vascular pathophysiology, diagnostics, and therapy
WO2019102593A1 (ja) * 2017-11-24 2019-05-31 株式会社Ihi 細胞培養装置
JP6664755B1 (ja) * 2018-10-02 2020-03-13 学校法人同志社 角膜内皮細胞を保存するための方法および容器
WO2020071438A1 (ja) * 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
US20220133659A1 (en) * 2019-03-12 2022-05-05 Nissan Chemical Corporation Therapeutic agent for corneal diseases
JP2023025311A (ja) * 2020-02-05 2023-02-22 味の素株式会社 タンパク質の製造方法
CN112522179A (zh) * 2020-12-23 2021-03-19 江苏艾尔康生物医药科技有限公司 一种角膜内皮细胞的分离培养方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
JP3421217B2 (ja) 1995-11-20 2003-06-30 麒麟麦酒株式会社 Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
US6153593A (en) 1996-06-05 2000-11-28 The General Hospital Corporation Laminin 5 and the formation of basement membrane structure
FR2765781B1 (fr) 1997-07-08 1999-09-24 Gioia Bruno Di Procede de fabrication d'un accessoire de mode, dispositif pour la mise en oeuvre du procede et accessoire de mode ainsi realise
US6042262A (en) 1997-07-29 2000-03-28 Stryker Technologies Corportion Apparatus for storing, mixing, and dispensing two-component bone cement
US6693169B1 (en) 1998-10-13 2004-02-17 The General Hospital Corporation Laminin 5, 13 and 14 and uses thereof
EP1177290A2 (en) 1999-04-30 2002-02-06 Biostratum, Inc. Recombinant laminin 5
US6635616B2 (en) 2000-05-01 2003-10-21 The General Hospital Corporation Laminin 15
WO2002050111A2 (en) 2000-12-21 2002-06-27 Biostratum, Inc. Isolated laminin 10
PE20020958A1 (es) 2001-03-23 2002-11-14 Bayer Corp Inhibidores de la rho-quinasa
TWI261055B (en) 2001-03-23 2006-09-01 Bayer Corp Rho-Kinase Inhibitors
CA2443918C (en) 2001-04-11 2012-06-05 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents containing rho kinase inhibitors
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
CA2472619A1 (en) 2002-01-10 2003-07-24 Bayer Corporation Fused pyrimidine derivates as rho-kinase inhibitors
MXPA04007196A (es) 2002-01-23 2005-06-08 Bayer Pharmaceuticals Corp Inhibidores de rho-quinasa.
CA2483659A1 (en) * 2002-04-30 2003-11-13 Amniotec Inc. Corneal endothelium-like sheet and method of constructing the same
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
AU2003281623B8 (en) 2002-07-22 2009-06-11 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
CA2400996A1 (en) 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
EP1644365A2 (en) 2003-07-02 2006-04-12 Biofocus Discovery Ltd Pyrazine and pyridine derivatives as rho kinase inhibitors
WO2005039564A1 (en) 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
JP2007507549A (ja) 2003-10-06 2007-03-29 グラクソ　グループ　リミテッド キナーゼ阻害剤としての１，６，７−三置換アザベンゾイミダゾールの調製
WO2005037197A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
JP2007507547A (ja) 2003-10-06 2007-03-29 グラクソ　グループ　リミテッド キナーゼ阻害剤としての１，７−二置換アザベンゾイミダゾールの調製
CN100560142C (zh) * 2003-10-10 2009-11-18 细胞生物工程公司 用于在生物聚合物上培养角膜内皮细胞和相关细胞以及产生人工角膜移植物的方法和组合物
WO2005037144A2 (en) 2003-10-10 2005-04-28 Cellular Bioengineering, Inc. Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants
KR20070053152A (ko) 2003-10-10 2007-05-23 셀룰라 바이오엔지니어링 인코포레이티드 인간의 각막 내피세포 및 각막세포 이식을 위한 세포배양및 수득방법
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
US7563906B2 (en) 2003-10-15 2009-07-21 Ube Industries, Ltd. Indazole derivatives
EP2438814A3 (en) 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
WO2005087250A1 (en) 2004-02-12 2005-09-22 GOVERNMENT OF THE UNITED STATES OF AMERICA, as respresented by Secretary, Department of Health and Human Services Therapeutic administration of the scrambled anti-angiogenic peptide c16y
EP1720874A4 (en) 2004-02-24 2010-03-03 Bioaxone Therapeutique Inc 4-SUBSTITUTED PIPERIDINE DERIVATIVES
TW200604168A (en) 2004-04-02 2006-02-01 Vertex Pharma Azaindoles useful as inhibitors of rock and other protein kinases
JPWO2006057270A1 (ja) 2004-11-26 2008-06-05 旭化成ファーマ株式会社 含窒素３環化合物
AU2006285915B2 (en) 2005-08-30 2011-02-24 Asahi Kasei Pharma Corporation Sulfonamide compound
JP5255846B2 (ja) 2006-01-19 2013-08-07 千寿製薬株式会社 生体内で細胞増殖可能な角膜内皮製剤
US20090175835A1 (en) 2006-02-07 2009-07-09 Korea Institute Of Radiological & Medical Sciences Composition for treating damage of central or peripheral nerve system
WO2007127172A2 (en) 2006-04-27 2007-11-08 The Trustees Of Columbia University In The City Of New York Layered bio-adhesive compositions and uses thereof
US8951799B2 (en) 2007-01-04 2015-02-10 Biolamina Ab Composition and method for enabling proliferation of pluripotent stem cells
KR20220151013A (ko) * 2007-08-29 2022-11-11 센주 세이야꾸 가부시키가이샤 각막 내피 세포 접착 촉진제
US20090306772A1 (en) 2008-04-18 2009-12-10 The Regents Of The University Of California Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane
US8680182B2 (en) 2009-06-04 2014-03-25 Clemson University Research Foundation Methods for promoting the revascularization and reenervation of CNS lesions
WO2010140464A1 (ja) 2009-06-05 2010-12-09 国立大学法人 熊本大学 細胞の分化誘導方法
JP5590646B2 (ja) * 2009-10-08 2014-09-17 国立大学法人大阪大学 ヒト多能性幹細胞用培養基材およびその利用
RU2418067C1 (ru) 2009-12-03 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ культивирования клеток
WO2011080984A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
MX343462B (es) 2010-12-17 2016-11-07 Biolamina Ab Medio del cultivo celular.
JPWO2012173207A1 (ja) 2011-06-14 2015-02-23 独立行政法人理化学研究所 網膜細胞への分化誘導方法
JP5761827B2 (ja) * 2011-07-15 2015-08-12 国立大学法人大阪大学 角膜内皮細胞の調製方法
JPWO2013047763A1 (ja) 2011-09-29 2015-03-30 オリエンタル酵母工業株式会社 ラミニン５１１を含んだ系で哺乳類細胞を培養する方法
TW202434266A (zh) 2011-11-14 2024-09-01 安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
JP5985207B2 (ja) 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
CA3114895A1 (en) 2011-11-25 2013-05-30 Sumitomo Chemical Company, Limited Artificial cell aggregate comprising retinal tissue
PL2788472T3 (pl) * 2011-12-06 2019-06-28 Astellas Institute For Regenerative Medicine Sposób ukierunkowanego różnicowania z wytwarzaniem komórek śródbłonka rogówki
WO2013148377A1 (en) 2012-03-25 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for modulating hair growth using truncated laminin-511
PT2925856T (pt) 2012-12-03 2018-06-15 Biolamina Ab Métodos de produção de células epr
SG10201802877WA (en) 2013-10-09 2018-05-30 Healios Kk Method of producing retinal pigment epithelial cell
MX387839B (es) 2014-10-31 2025-03-04 Senju Pharma Co Laminina para usarse en el tratamiento de una enfermedad, un trastorno o una afección de un endotelio de córnea.
EP3213761B1 (en) 2014-10-31 2021-05-19 Kyoto Prefectural Public University Corporation Novel treatment of retina using laminin
US12403161B2 (en) 2018-06-29 2025-09-02 Stellular Bio, Inc. Compositions for drug delivery and methods of use thereof

Also Published As

Publication number Publication date
JP2016539641A (ja) 2016-12-22
ES2763433T3 (es) 2020-05-28
JP6470286B2 (ja) 2019-02-13
RU2016125225A (ru) 2018-01-09
EP3074508B1 (en) 2019-11-06
CA2931280A1 (en) 2015-06-04
JP2019054828A (ja) 2019-04-11
JP2020188778A (ja) 2020-11-26
RU2704984C1 (ru) 2019-11-01
MX2016006915A (es) 2017-01-23
EP3074508A1 (en) 2016-10-05
WO2015080297A1 (en) 2015-06-04
US11624053B2 (en) 2023-04-11
CN105814195A (zh) 2016-07-27
US20170002318A1 (en) 2017-01-05

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (J

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements