CN105814195A - 层粘连蛋白应用于角膜内皮细胞培养 - Google Patents
层粘连蛋白应用于角膜内皮细胞培养 Download PDFInfo
- Publication number
- CN105814195A CN105814195A CN201480065134.XA CN201480065134A CN105814195A CN 105814195 A CN105814195 A CN 105814195A CN 201480065134 A CN201480065134 A CN 201480065134A CN 105814195 A CN105814195 A CN 105814195A
- Authority
- CN
- China
- Prior art keywords
- laminin
- chain
- corneal endothelial
- endothelial cells
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-244972 | 2013-11-27 | ||
| JP2013244972 | 2013-11-27 | ||
| PCT/JP2014/081917 WO2015080297A1 (en) | 2013-11-27 | 2014-11-26 | Application of laminin to corneal endothelial cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105814195A true CN105814195A (zh) | 2016-07-27 |
Family
ID=52432880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480065134.XA Pending CN105814195A (zh) | 2013-11-27 | 2014-11-26 | 层粘连蛋白应用于角膜内皮细胞培养 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11624053B2 (enExample) |
| EP (1) | EP3074508B1 (enExample) |
| JP (3) | JP6470286B2 (enExample) |
| CN (1) | CN105814195A (enExample) |
| BR (1) | BR112016011096A2 (enExample) |
| CA (1) | CA2931280A1 (enExample) |
| ES (1) | ES2763433T3 (enExample) |
| MX (1) | MX2016006915A (enExample) |
| RU (1) | RU2704984C1 (enExample) |
| WO (1) | WO2015080297A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112522179A (zh) * | 2020-12-23 | 2021-03-19 | 江苏艾尔康生物医药科技有限公司 | 一种角膜内皮细胞的分离培养方法 |
| CN113015429A (zh) * | 2018-10-02 | 2021-06-22 | 学校法人同志社 | 用于保存角膜内皮细胞的方法和容器 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201903889T4 (tr) | 2011-12-06 | 2019-04-22 | Astellas Inst For Regenerative Medicine | Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem. |
| WO2016067628A1 (ja) | 2014-10-31 | 2016-05-06 | 京都府公立大学法人 | ラミニンによる角膜の新規治療 |
| US11918630B2 (en) | 2014-10-31 | 2024-03-05 | Kyoto Prefectural Public University Corporation | Treatment of retina and nerve using laminin |
| JP6849957B2 (ja) * | 2015-11-10 | 2021-03-31 | 国立大学法人京都大学 | ラミニンフラグメント含有培地を用いる細胞培養方法 |
| EP3375860A4 (en) * | 2015-11-10 | 2019-07-03 | Nikkiso Co., Ltd. | CELL SUPPORT COMPOSITE AND METHOD FOR PRODUCING THE CELL SUPPORT COMPOSITE |
| AU2018215170B2 (en) * | 2017-01-31 | 2021-11-11 | Osaka University | Differentiation control method for pluripotent stem cells |
| WO2019079809A1 (en) * | 2017-10-22 | 2019-04-25 | The Johns Hopkins University | BIOMIMETIC PLATFORMS FOR MODELING VASCULAR PHYSIOPATHOLOGY, DIAGNOSIS AND THERAPY |
| WO2019102593A1 (ja) * | 2017-11-24 | 2019-05-31 | 株式会社Ihi | 細胞培養装置 |
| JP6664755B1 (ja) * | 2018-10-02 | 2020-03-13 | 学校法人同志社 | 角膜内皮細胞を保存するための方法および容器 |
| WO2020184605A1 (ja) * | 2019-03-12 | 2020-09-17 | 日産化学株式会社 | 角膜疾患治療剤 |
| JP2023025311A (ja) * | 2020-02-05 | 2023-02-22 | 味の素株式会社 | タンパク質の製造方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1893988A (zh) * | 2003-10-10 | 2007-01-10 | 细胞生物工程公司 | 用于在生物聚合物上培养角膜内皮细胞和相关细胞以及产生人工角膜移植物的方法和组合物 |
| CN102597217A (zh) * | 2009-10-08 | 2012-07-18 | 国立大学法人大阪大学 | 人多能干细胞用培养基质及其用途 |
| WO2013012087A1 (ja) * | 2011-07-15 | 2013-01-24 | 国立大学法人大阪大学 | 角膜内皮細胞の調製方法 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
| JP3421217B2 (ja) | 1995-11-20 | 2003-06-30 | 麒麟麦酒株式会社 | Rho標的タンパク質Rhoキナーゼ |
| JP2000513220A (ja) | 1996-06-05 | 2000-10-10 | ザ ジェネラル ホスピタル コーポレイション | ラミニン―5及び基底膜構造の形成 |
| FR2765781B1 (fr) | 1997-07-08 | 1999-09-24 | Gioia Bruno Di | Procede de fabrication d'un accessoire de mode, dispositif pour la mise en oeuvre du procede et accessoire de mode ainsi realise |
| US6042262A (en) | 1997-07-29 | 2000-03-28 | Stryker Technologies Corportion | Apparatus for storing, mixing, and dispensing two-component bone cement |
| US6693169B1 (en) | 1998-10-13 | 2004-02-17 | The General Hospital Corporation | Laminin 5, 13 and 14 and uses thereof |
| AU4675300A (en) | 1999-04-30 | 2000-11-17 | Biostatum, Inc. | Recombinant laminin 5 |
| US6635616B2 (en) | 2000-05-01 | 2003-10-21 | The General Hospital Corporation | Laminin 15 |
| US6933273B2 (en) | 2000-12-21 | 2005-08-23 | Karl Tryggvason | Isolated laminin 10 |
| PE20021011A1 (es) | 2001-03-23 | 2003-02-01 | Bayer Corp | Derivados quinazolinicos como inhibidores de la rho-quinasa |
| DE60218138T2 (de) | 2001-03-23 | 2007-09-20 | Bayer Pharmaceuticals Corp., West Haven | Rho-kinase inhibitoren |
| US7109208B2 (en) | 2001-04-11 | 2006-09-19 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents |
| JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Rhoキナーゼ阻害剤 |
| ES2305435T3 (es) | 2002-01-10 | 2008-11-01 | Bayer Healthcare Ag | Inhibidores de la rho-quinasa. |
| JP4423043B2 (ja) | 2002-01-23 | 2010-03-03 | バイエル ファーマセチカル コーポレーション | Rho−キナーゼ阻害剤 |
| JP2004024852A (ja) | 2002-04-30 | 2004-01-29 | Amniotec:Kk | 角膜内皮様シート、及びその作製方法 |
| CA2483659A1 (en) * | 2002-04-30 | 2003-11-13 | Amniotec Inc. | Corneal endothelium-like sheet and method of constructing the same |
| EP1541559A4 (en) | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE |
| CA2400996A1 (en) | 2002-09-03 | 2004-03-03 | Lisa Mckerracher | 1,4-substituted cyclohexane derivatives |
| US7160894B2 (en) | 2003-06-06 | 2007-01-09 | Asahi Kasei Pharma Corporation | Tricyclic compound |
| EP1644365A2 (en) | 2003-07-02 | 2006-04-12 | Biofocus Discovery Ltd | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| US20050182061A1 (en) | 2003-10-02 | 2005-08-18 | Jeremy Green | Phthalimide compounds useful as protein kinase inhibitors |
| US20070004771A1 (en) | 2003-10-06 | 2007-01-04 | Glaxo Group Limited | Preparation of 1,6,7-trisubstituted azabenzimidazoles as kinase inhibitors |
| JP4764823B2 (ja) | 2003-10-06 | 2011-09-07 | グラクソ グループ リミテッド | キナーゼ阻害剤としての1,6−二置換アザベンゾイミダゾールの調製 |
| US20070123561A1 (en) | 2003-10-06 | 2007-05-31 | Dennis Lee | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors |
| US20070092550A1 (en) | 2003-10-10 | 2007-04-26 | Cellular Bioengineering, Inc. | Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants |
| DE602004030273D1 (de) | 2003-10-10 | 2011-01-05 | Ge Ming Lui | Menschliche hornhautendothelzellen und verfahren zur gewinnung und kultivierung von zellen zur hornhautzelltransplantation |
| EP2468729B1 (en) | 2003-10-15 | 2013-12-25 | Ube Industries, Ltd. | Novel indazole derivative |
| JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| JP2007015928A (ja) | 2003-10-15 | 2007-01-25 | Ube Ind Ltd | 新規オレフィン誘導体 |
| EP2438815A3 (en) | 2004-01-23 | 2012-10-03 | Advanced Cell Technology, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| CA2555792C (en) | 2004-02-12 | 2013-04-02 | Government Of The United States Of America, As Represented By Secretary, Department Of Health And Human Services | Therapeutic administration of the scrambled anti-angiogenic peptide c16y |
| EP1720874A4 (en) | 2004-02-24 | 2010-03-03 | Bioaxone Therapeutique Inc | 4-SUBSTITUTED PIPERIDINE DERIVATIVES |
| AR049333A1 (es) | 2004-04-02 | 2006-07-19 | Vertex Pharma | Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas. |
| JPWO2006057270A1 (ja) | 2004-11-26 | 2008-06-05 | 旭化成ファーマ株式会社 | 含窒素3環化合物 |
| KR101149954B1 (ko) | 2005-08-30 | 2012-06-01 | 아사히 가세이 파마 가부시키가이샤 | 술폰아미드 화합물 |
| US10052411B2 (en) | 2006-01-19 | 2018-08-21 | Senju Pharmaceutical Co., Ltd. | Methods of treating corneal related diseases by corneal endothelial preparation which enables cells to grow in vivo |
| US20090175835A1 (en) | 2006-02-07 | 2009-07-09 | Korea Institute Of Radiological & Medical Sciences | Composition for treating damage of central or peripheral nerve system |
| WO2007127172A2 (en) | 2006-04-27 | 2007-11-08 | The Trustees Of Columbia University In The City Of New York | Layered bio-adhesive compositions and uses thereof |
| US8951799B2 (en) | 2007-01-04 | 2015-02-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent stem cells |
| WO2009028631A1 (ja) * | 2007-08-29 | 2009-03-05 | Senju Pharmaceutical Co., Ltd. | 角膜内皮細胞接着促進剤 |
| US20090306772A1 (en) | 2008-04-18 | 2009-12-10 | The Regents Of The University Of California | Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane |
| US8680182B2 (en) | 2009-06-04 | 2014-03-25 | Clemson University Research Foundation | Methods for promoting the revascularization and reenervation of CNS lesions |
| WO2010140464A1 (ja) | 2009-06-05 | 2010-12-09 | 国立大学法人 熊本大学 | 細胞の分化誘導方法 |
| RU2418067C1 (ru) | 2009-12-03 | 2011-05-10 | Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" | Способ культивирования клеток |
| WO2011080984A1 (en) | 2009-12-29 | 2011-07-07 | Senju Pharmaceutical Co., Ltd. | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction |
| KR101966033B1 (ko) | 2010-12-17 | 2019-04-04 | 바이오라미나 에이비 | 재조합 라미닌-521 |
| JPWO2012173207A1 (ja) | 2011-06-14 | 2015-02-23 | 独立行政法人理化学研究所 | 網膜細胞への分化誘導方法 |
| JPWO2013047763A1 (ja) | 2011-09-29 | 2015-03-30 | オリエンタル酵母工業株式会社 | ラミニン511を含んだ系で哺乳類細胞を培養する方法 |
| JP6506023B2 (ja) | 2011-11-14 | 2019-04-24 | アステラス インスティテュート フォー リジェネレイティブ メディシン | ヒトrpe細胞医薬品およびその使用 |
| EP2784152B1 (en) | 2011-11-25 | 2019-04-10 | Sumitomo Chemical Company, Limited | Methods for producing retinal tissue and retina-related cell |
| JP5985207B2 (ja) | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜色素上皮細胞の製造方法 |
| TR201903889T4 (tr) * | 2011-12-06 | 2019-04-22 | Astellas Inst For Regenerative Medicine | Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem. |
| US9351914B2 (en) | 2012-03-25 | 2016-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating hair growth using truncated laminin-511 |
| RS57257B1 (sr) | 2012-12-03 | 2018-08-31 | Biolamina Ab | Metodi proizvodnje rpe ćelija |
| JP6518878B2 (ja) | 2013-10-09 | 2019-05-29 | 株式会社ヘリオス | 網膜色素上皮細胞の製造方法 |
| US11918630B2 (en) | 2014-10-31 | 2024-03-05 | Kyoto Prefectural Public University Corporation | Treatment of retina and nerve using laminin |
| WO2016067628A1 (ja) | 2014-10-31 | 2016-05-06 | 京都府公立大学法人 | ラミニンによる角膜の新規治療 |
| CA3105205A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
-
2014
- 2014-11-26 CN CN201480065134.XA patent/CN105814195A/zh active Pending
- 2014-11-26 JP JP2016535065A patent/JP6470286B2/ja active Active
- 2014-11-26 BR BR112016011096A patent/BR112016011096A2/pt not_active Application Discontinuation
- 2014-11-26 CA CA2931280A patent/CA2931280A1/en not_active Abandoned
- 2014-11-26 US US15/100,147 patent/US11624053B2/en active Active
- 2014-11-26 RU RU2016125225A patent/RU2704984C1/ru not_active IP Right Cessation
- 2014-11-26 EP EP14831100.4A patent/EP3074508B1/en active Active
- 2014-11-26 MX MX2016006915A patent/MX2016006915A/es unknown
- 2014-11-26 ES ES14831100T patent/ES2763433T3/es active Active
- 2014-11-26 WO PCT/JP2014/081917 patent/WO2015080297A1/en not_active Ceased
-
2019
- 2019-01-17 JP JP2019006098A patent/JP2019054828A/ja not_active Withdrawn
-
2020
- 2020-06-05 JP JP2020098407A patent/JP2020188778A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1893988A (zh) * | 2003-10-10 | 2007-01-10 | 细胞生物工程公司 | 用于在生物聚合物上培养角膜内皮细胞和相关细胞以及产生人工角膜移植物的方法和组合物 |
| CN102597217A (zh) * | 2009-10-08 | 2012-07-18 | 国立大学法人大阪大学 | 人多能干细胞用培养基质及其用途 |
| WO2013012087A1 (ja) * | 2011-07-15 | 2013-01-24 | 国立大学法人大阪大学 | 角膜内皮細胞の調製方法 |
Non-Patent Citations (2)
| Title |
|---|
| MONIQUE AUMAILLEY 等: "A simplified laminin nomenclature", 《MATRIX BIOLOGY》 * |
| 李姝燕: "层粘连蛋白作用下角膜内皮细胞增殖与细胞骨架的相关性", 《眼科研究》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113015429A (zh) * | 2018-10-02 | 2021-06-22 | 学校法人同志社 | 用于保存角膜内皮细胞的方法和容器 |
| CN112522179A (zh) * | 2020-12-23 | 2021-03-19 | 江苏艾尔康生物医药科技有限公司 | 一种角膜内皮细胞的分离培养方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20170002318A1 (en) | 2017-01-05 |
| US11624053B2 (en) | 2023-04-11 |
| JP2016539641A (ja) | 2016-12-22 |
| CA2931280A1 (en) | 2015-06-04 |
| RU2704984C1 (ru) | 2019-11-01 |
| EP3074508B1 (en) | 2019-11-06 |
| JP2019054828A (ja) | 2019-04-11 |
| WO2015080297A1 (en) | 2015-06-04 |
| MX2016006915A (es) | 2017-01-23 |
| ES2763433T3 (es) | 2020-05-28 |
| JP6470286B2 (ja) | 2019-02-13 |
| JP2020188778A (ja) | 2020-11-26 |
| RU2016125225A (ru) | 2018-01-09 |
| EP3074508A1 (en) | 2016-10-05 |
| BR112016011096A2 (pt) | 2017-09-19 |
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Application publication date: 20160727 |