JP6464098B2 - ボルチオキセチンの製造方法 - Google Patents
ボルチオキセチンの製造方法 Download PDFInfo
- Publication number
- JP6464098B2 JP6464098B2 JP2015558446A JP2015558446A JP6464098B2 JP 6464098 B2 JP6464098 B2 JP 6464098B2 JP 2015558446 A JP2015558446 A JP 2015558446A JP 2015558446 A JP2015558446 A JP 2015558446A JP 6464098 B2 JP6464098 B2 JP 6464098B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- equivalents
- piperazine
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767883P | 2013-02-22 | 2013-02-22 | |
| US61/767,883 | 2013-02-22 | ||
| DKPA201300104 | 2013-02-22 | ||
| DKPA201300104 | 2013-02-22 | ||
| PCT/EP2014/053313 WO2014128207A1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509042A JP2016509042A (ja) | 2016-03-24 |
| JP2016509042A5 JP2016509042A5 (enExample) | 2017-03-16 |
| JP6464098B2 true JP6464098B2 (ja) | 2019-02-06 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558446A Active JP6464098B2 (ja) | 2013-02-22 | 2014-02-20 | ボルチオキセチンの製造方法 |
Country Status (37)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2605652B1 (en) | 2010-08-18 | 2017-11-08 | Samumed, LLC | Diketones and hydroxyketones as catenin signaling pathway activators |
| ES2709824T3 (es) | 2013-02-22 | 2019-04-17 | Samumed Llc | Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina |
| DK3206686T3 (da) | 2014-08-20 | 2019-12-16 | Samumed Llc | Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| EP3274330A1 (en) | 2015-03-26 | 2018-01-31 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| EP3414216B1 (en) * | 2016-02-08 | 2020-10-21 | AAA Chemistry ApS | Arylation of aliphatic amines |
| JP2019524682A (ja) | 2016-07-01 | 2019-09-05 | ハー・ルンドベック・アクチエゼルスカベット | 抗うつ作用の速い発現のためのボルチオキセチン投与計画 |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| MXPA04005989A (es) * | 2001-12-20 | 2004-09-27 | Lundbeck & Co As H | Derivados de ariloxifenilo y arilsulfanilfenilo. |
| KR20090028712A (ko) * | 2006-06-16 | 2009-03-19 | 하. 룬트벡 아크티에 셀스카브 | 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ｈｔ3 및 5-ｈｔ1ａ 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진 |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2014
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en not_active Ceased
- 2014-02-20 SM SM20170238T patent/SMT201700238T1/it unknown
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active Active
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
- 2014-02-20 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807B1/en unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2017
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6464098B2 (ja) | ボルチオキセチンの製造方法 | |
| JP6018644B2 (ja) | １−［２−（２，４−ジメチル−フェニルスルファニル）−フェニル］−ピペラジンの製造方法 | |
| JP5738774B2 (ja) | １−［２−（２，４−ジメチルフェニルスルファニル）フェニル］ピペラジンの精製 | |
| JP2011525182A (ja) | アポトーシス促進剤ａｂｔ−２６３の調製のための方法 | |
| JP2010513494A5 (enExample) | ||
| WO2015188686A1 (zh) | 塞瑞替尼及其中间体的制备方法 | |
| JP2016509042A5 (enExample) | ||
| PT2029567E (pt) | Processo para a produção de derivados de benzopiran-2-ol | |
| CN103788019A (zh) | 沃替西汀的制备方法 | |
| CN103124718A (zh) | 合成2-取代的-1,4-二苯胺的方法 | |
| CN105348220B (zh) | 一种氢溴酸沃替西汀的合成方法 | |
| CN104628676A (zh) | 一种Vortioxetine的制备方法 | |
| US20180072690A1 (en) | Methods for Making Serotonin Reuptake Inhibitors | |
| TW513410B (en) | Synthesis of intermediates useful in preparing tricyclic compounds | |
| HK1216098B (en) | Vortioxetine manufacturing process | |
| NZ710779A (en) | Vortioxetine manufacturing process | |
| OA17454A (en) | Vortioxetine manufacturing process. | |
| JPS6225666B2 (enExample) | ||
| NZ710779B2 (en) | Vortioxetine manufacturing process | |
| CN114181145A (zh) | 一种依匹哌唑中间体的制备方法 | |
| WO2012051737A1 (zh) | 西那卡塞及其药用盐的制备方法 | |
| JP5439745B2 (ja) | ハロゲノメチルペンタフルオロスルファニルベンゼン化合物及びその製造方法 | |
| JP2003221388A (ja) | ピペラジン化合物の製造方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170210 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170210 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20171228 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180130 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180427 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180904 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181130 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20181218 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190107 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6464098 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |