MA38338B1 - Procédé de fabrication de vortioxétine - Google Patents

Procédé de fabrication de vortioxétine

Info

Publication number
MA38338B1
MA38338B1 MA38338A MA38338A MA38338B1 MA 38338 B1 MA38338 B1 MA 38338B1 MA 38338 A MA38338 A MA 38338A MA 38338 A MA38338 A MA 38338A MA 38338 B1 MA38338 B1 MA 38338B1
Authority
MA
Morocco
Prior art keywords
vortioxetine
manufacturing
formula
dimethylthiophenol
decomplexation
Prior art date
Application number
MA38338A
Other languages
English (en)
French (fr)
Other versions
MA38338A1 (fr
Inventor
Thomas Ruhland
Kim Lasse Christensen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MA38338A1 publication Critical patent/MA38338A1/fr
Publication of MA38338B1 publication Critical patent/MA38338B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
MA38338A 2013-02-22 2014-02-20 Procédé de fabrication de vortioxétine MA38338B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201300104 2013-02-22
PCT/EP2014/053313 WO2014128207A1 (en) 2013-02-22 2014-02-20 Vortioxetine manufacturing process

Publications (2)

Publication Number Publication Date
MA38338A1 MA38338A1 (fr) 2016-09-30
MA38338B1 true MA38338B1 (fr) 2018-10-31

Family

ID=59215387

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38338A MA38338B1 (fr) 2013-02-22 2014-02-20 Procédé de fabrication de vortioxétine

Country Status (37)

Country Link
US (1) US9353073B2 (enExample)
EP (1) EP2958903B1 (enExample)
JP (1) JP6464098B2 (enExample)
KR (1) KR102230628B1 (enExample)
CN (1) CN104995181B (enExample)
AP (1) AP2015008640A0 (enExample)
AU (1) AU2014220735B2 (enExample)
BR (1) BR112015019268B1 (enExample)
CA (1) CA2901821A1 (enExample)
CL (1) CL2015002309A1 (enExample)
CR (1) CR20150423A (enExample)
CY (1) CY1118883T1 (enExample)
DK (1) DK2958903T3 (enExample)
DO (1) DOP2015000187A (enExample)
EA (1) EA027756B1 (enExample)
ES (1) ES2625380T3 (enExample)
GE (1) GEP201706749B (enExample)
HR (1) HRP20170607T1 (enExample)
IL (1) IL240501B (enExample)
LT (1) LT2958903T (enExample)
MA (1) MA38338B1 (enExample)
ME (1) ME02671B (enExample)
MX (1) MX362355B (enExample)
MY (1) MY172337A (enExample)
PE (1) PE20151589A1 (enExample)
PH (1) PH12015501807B1 (enExample)
PL (1) PL2958903T3 (enExample)
PT (1) PT2958903T (enExample)
RS (1) RS55932B1 (enExample)
RU (1) RU2652265C2 (enExample)
SG (1) SG11201506651SA (enExample)
SI (1) SI2958903T1 (enExample)
SM (1) SMT201700238T1 (enExample)
TN (1) TN2015000335A1 (enExample)
UA (1) UA116236C2 (enExample)
WO (1) WO2014128207A1 (enExample)
ZA (1) ZA201506050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3311666T1 (sl) 2010-08-18 2021-09-30 Biosplice Therapeutics, Inc. Diketoni in hidroksiketoni, kot aktivatorji signalne poti katenina
PL2968249T3 (pl) 2013-02-22 2019-06-28 Samumed, Llc Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny
RS59797B1 (sr) 2014-08-20 2020-02-28 Samumed Llc Gama-diketoni za tretman i prevenciju starenja kože i bora
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
EP3274330A1 (en) 2015-03-26 2018-01-31 Cipla Limited Method for making serotonin reuptake inhibitors
CN106279065A (zh) * 2015-05-12 2017-01-04 北京深蓝海生物医药科技有限公司 一种氢溴酸沃替西汀的精制转晶方法
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
EP3414231B1 (en) * 2016-02-08 2020-08-19 H. Lundbeck A/S Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
MA45532A (fr) 2016-07-01 2019-05-08 H Lundbeck As Schémas posologiques de la vortioxétine destinés à une apparition rapide de l'effet antidépresseur
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN109912538B (zh) * 2019-01-22 2021-03-12 安徽赛乐普制药有限公司 一种抗抑郁药沃替西汀的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE60219521T2 (de) * 2001-12-20 2007-08-16 H. Lundbeck A/S Aryloxyphenyl und arylsulfanylphenylderivate
BR122020011920A2 (pt) * 2006-06-16 2020-08-25 Lundbeck & Co As H composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e processos para a preparação de um composto, e para a fabricação de um composto
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
CN104995181A (zh) 2015-10-21
AU2014220735A1 (en) 2015-08-20
BR112015019268A2 (pt) 2020-01-28
RU2015134407A (ru) 2017-03-28
MX2015010656A (es) 2015-12-17
CR20150423A (es) 2015-10-20
MA38338A1 (fr) 2016-09-30
UA116236C2 (uk) 2018-02-26
JP2016509042A (ja) 2016-03-24
HK1216098A1 (en) 2016-10-14
LT2958903T (lt) 2017-08-25
AP2015008640A0 (en) 2015-08-31
SG11201506651SA (en) 2015-09-29
JP6464098B2 (ja) 2019-02-06
WO2014128207A1 (en) 2014-08-28
HRP20170607T1 (hr) 2017-06-30
EA027756B1 (ru) 2017-08-31
MX362355B (es) 2019-01-14
US20160009670A1 (en) 2016-01-14
KR20150118146A (ko) 2015-10-21
PL2958903T3 (pl) 2017-08-31
PH12015501807B1 (en) 2019-05-31
PT2958903T (pt) 2017-05-26
IL240501A0 (en) 2015-09-24
ME02671B (me) 2017-06-20
ZA201506050B (en) 2017-08-30
AU2014220735B2 (en) 2017-06-22
CL2015002309A1 (es) 2016-03-04
SI2958903T1 (sl) 2017-09-29
EP2958903A1 (en) 2015-12-30
BR112015019268B1 (pt) 2023-01-10
PE20151589A1 (es) 2015-12-03
KR102230628B1 (ko) 2021-03-22
CA2901821A1 (en) 2014-08-28
CY1118883T1 (el) 2018-01-10
IL240501B (en) 2018-08-30
RU2652265C2 (ru) 2018-04-27
PH12015501807A1 (en) 2015-11-09
DOP2015000187A (es) 2015-11-30
GEP201706749B (en) 2017-10-10
ES2625380T3 (es) 2017-07-19
TN2015000335A1 (en) 2017-01-03
US9353073B2 (en) 2016-05-31
DK2958903T3 (en) 2017-05-15
SMT201700238T1 (it) 2017-07-18
CN104995181B (zh) 2017-03-08
MY172337A (en) 2019-11-21
EP2958903B1 (en) 2017-04-12
EA201591349A1 (ru) 2015-12-30
RS55932B1 (sr) 2017-09-29

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