CL2015002309A1 - Proceso de fabricacion de vortioxetina. - Google Patents
Proceso de fabricacion de vortioxetina.Info
- Publication number
- CL2015002309A1 CL2015002309A1 CL2015002309A CL2015002309A CL2015002309A1 CL 2015002309 A1 CL2015002309 A1 CL 2015002309A1 CL 2015002309 A CL2015002309 A CL 2015002309A CL 2015002309 A CL2015002309 A CL 2015002309A CL 2015002309 A1 CL2015002309 A1 CL 2015002309A1
- Authority
- CL
- Chile
- Prior art keywords
- vortioxetine
- manufacturing process
- salts
- vortioxetina
- piperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201300104 | 2013-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015002309A1 true CL2015002309A1 (es) | 2016-03-04 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015002309A CL2015002309A1 (es) | 2013-02-22 | 2015-08-18 | Proceso de fabricacion de vortioxetina. |
Country Status (37)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2592694C2 (ru) | 2010-08-18 | 2016-07-27 | СЭМЬЮМЕД, ЭлЭлСи | Дикетоны и гидроксикетоны в качестве активатора сигнального пути катенина |
| DK2968249T3 (en) | 2013-02-22 | 2019-03-04 | Samumed Llc | GAMMA DIKETONS AS WNT / BETA-CATENIN SIGNAL ROAD ACTIVATORS |
| MA40454B1 (fr) | 2014-08-20 | 2020-01-31 | Samumed Llc | Gamma-dicétones pour le traitement et la prévention des rides et du vieillissement de la peau |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| US20180072690A1 (en) | 2015-03-26 | 2018-03-15 | Cipla Limited | Methods for Making Serotonin Reuptake Inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| JP6987064B2 (ja) * | 2016-02-08 | 2021-12-22 | ハー・ルンドベック・アクチエゼルスカベット | １−［２−（２，４−ジメチル−フェニルスルファニル）−フェニル］ピペラジンの合成 |
| WO2018002115A1 (en) | 2016-07-01 | 2018-01-04 | H. Lundbeck A/S | Vortioxetine dosing regimes for fast onset of antidepressant effect |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| ATE359276T1 (de) * | 2001-12-20 | 2007-05-15 | Lundbeck & Co As H | Aryloxyphenyl und arylsulfanylphenylderivate |
| PL2044043T5 (pl) * | 2006-06-16 | 2022-05-02 | H. Lundbeck A/S | Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2014
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 SM SM20170238T patent/SMT201700238T1/it unknown
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en not_active Ceased
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active Active
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807B1/en unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2017
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
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