HRP20170607T1 - Proizvodni postupak vortioksetina - Google Patents
Proizvodni postupak vortioksetina Download PDFInfo
- Publication number
- HRP20170607T1 HRP20170607T1 HRP20170607TT HRP20170607T HRP20170607T1 HR P20170607 T1 HRP20170607 T1 HR P20170607T1 HR P20170607T T HRP20170607T T HR P20170607TT HR P20170607 T HRP20170607 T HR P20170607T HR P20170607 T1 HRP20170607 T1 HR P20170607T1
- Authority
- HR
- Croatia
- Prior art keywords
- process according
- formula
- compound
- equivalents
- piperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767883P | 2013-02-22 | 2013-02-22 | |
| DKPA201300104 | 2013-02-22 | ||
| PCT/EP2014/053313 WO2014128207A1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
| EP14705524.8A EP2958903B1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170607T1 true HRP20170607T1 (hr) | 2017-06-30 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170607TT HRP20170607T1 (hr) | 2013-02-22 | 2014-02-20 | Proizvodni postupak vortioksetina |
Country Status (37)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2605652B1 (en) | 2010-08-18 | 2017-11-08 | Samumed, LLC | Diketones and hydroxyketones as catenin signaling pathway activators |
| ES2709824T3 (es) | 2013-02-22 | 2019-04-17 | Samumed Llc | Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina |
| DK3206686T3 (da) | 2014-08-20 | 2019-12-16 | Samumed Llc | Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| EP3274330A1 (en) | 2015-03-26 | 2018-01-31 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| EP3414216B1 (en) * | 2016-02-08 | 2020-10-21 | AAA Chemistry ApS | Arylation of aliphatic amines |
| JP2019524682A (ja) | 2016-07-01 | 2019-09-05 | ハー・ルンドベック・アクチエゼルスカベット | 抗うつ作用の速い発現のためのボルチオキセチン投与計画 |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| MXPA04005989A (es) * | 2001-12-20 | 2004-09-27 | Lundbeck & Co As H | Derivados de ariloxifenilo y arilsulfanilfenilo. |
| KR20090028712A (ko) * | 2006-06-16 | 2009-03-19 | 하. 룬트벡 아크티에 셀스카브 | 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ｈｔ3 및 5-ｈｔ1ａ 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진 |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2014
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en not_active Ceased
- 2014-02-20 SM SM20170238T patent/SMT201700238T1/it unknown
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active Active
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
- 2014-02-20 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807B1/en unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2017
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
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