ATE540941T1 - 1-ä2-(2,4-dimethylphenylsulfanyl)phenylüpiperaz n als verbindung mit kombinierter serotoninwiederaufnahme-, 5-ht3- und 5-ht1a- aktivität zur behandlung kognitiver störungen - Google Patents

1-ä2-(2,4-dimethylphenylsulfanyl)phenylüpiperaz n als verbindung mit kombinierter serotoninwiederaufnahme-, 5-ht3- und 5-ht1a- aktivität zur behandlung kognitiver störungen

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Publication number
ATE540941T1
ATE540941T1 AT07764495T AT07764495T ATE540941T1 AT E540941 T1 ATE540941 T1 AT E540941T1 AT 07764495 T AT07764495 T AT 07764495T AT 07764495 T AT07764495 T AT 07764495T AT E540941 T1 ATE540941 T1 AT E540941T1
Authority
AT
Austria
Prior art keywords
reuppost
phenylüpiperaz
dimethylphenylsulfanyl
compound
treatment
Prior art date
Application number
AT07764495T
Other languages
English (en)
Inventor
Benny Bang-Andersen
Andre Faldt
Arne Myrk
De Diego Heidi Lopez
Rene Holm
Tine Bryan Stensbyl
Lone Munch Ringgaard
Michael J Mealy
Michael Harold Rock
Jorgen Brodersen
Morten Jyrgensen
Nicholas Moore
Original Assignee
Lundbeck & Co As H
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Publication date
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Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE540941T1 publication Critical patent/ATE540941T1/de

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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AT07764495T 2006-06-16 2007-06-15 1-ä2-(2,4-dimethylphenylsulfanyl)phenylüpiperaz n als verbindung mit kombinierter serotoninwiederaufnahme-, 5-ht3- und 5-ht1a- aktivität zur behandlung kognitiver störungen ATE540941T1 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US80501406P 2006-06-16 2006-06-16
DKPA200600824 2006-06-16
US82666606P 2006-09-22 2006-09-22
DKPA200601223 2006-09-22
US86282606P 2006-10-25 2006-10-25
DKPA200601384 2006-10-25
DKPA200700427 2007-03-20
PCT/DK2007/050075 WO2007144005A1 (en) 2006-06-16 2007-06-15 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment

Publications (1)

Publication Number Publication Date
ATE540941T1 true ATE540941T1 (de) 2012-01-15

Family

ID=39722479

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07764495T ATE540941T1 (de) 2006-06-16 2007-06-15 1-ä2-(2,4-dimethylphenylsulfanyl)phenylüpiperaz n als verbindung mit kombinierter serotoninwiederaufnahme-, 5-ht3- und 5-ht1a- aktivität zur behandlung kognitiver störungen

Country Status (31)

Country Link
US (13) US8722684B2 (de)
EP (2) EP2439201B1 (de)
JP (8) JP4590013B2 (de)
KR (3) KR101445514B1 (de)
CN (3) CN102617513B (de)
AR (1) AR061481A1 (de)
AT (1) ATE540941T1 (de)
AU (1) AU2007260355B2 (de)
BR (3) BR122020011899B1 (de)
CA (1) CA2655212C (de)
CL (1) CL2011001610A1 (de)
CY (1) CY1112635T1 (de)
DK (1) DK2044043T4 (de)
EA (1) EA015287B1 (de)
ES (2) ES2432102T3 (de)
FI (1) FI2044043T5 (de)
HR (1) HRP20120173T4 (de)
IL (1) IL195511A (de)
MA (1) MA30575B1 (de)
MX (1) MX2008016141A (de)
MY (1) MY150647A (de)
NO (1) NO343929B3 (de)
NZ (1) NZ572986A (de)
PL (1) PL2044043T5 (de)
PT (1) PT2044043E (de)
RS (1) RS52205B2 (de)
SI (1) SI2044043T2 (de)
TN (1) TNSN08460A1 (de)
TW (1) TWI443091B (de)
WO (1) WO2007144005A1 (de)
ZA (1) ZA200810017B (de)

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UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
EP2439201B1 (de) * 2006-06-16 2013-08-07 H. Lundbeck A/S Verbindungen mit kombinierter sert, 5-ht3 und 5-ht1a-aktivität
JP7179035B2 (ja) * 2006-06-16 2022-11-28 ハー・ルンドベック・アクチエゼルスカベット 認識機能障害（ｃｏｇｎｉｔｉｖｅ ｉｍｐａｉｒｍｅｎｔ）を治療するための、組み合わされたセロトニン再取り込み、５－ＨＴ３および５－ＨＴ１Ａ活性を有する化合物としての１－［２－（２，４－ジメチルフェニルスルファニル）－フェニル］ピペラジン
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
AU2014200364B2 (en) * 2007-11-13 2015-09-17 H. Lundbeck A/S Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
US8940746B2 (en) * 2009-04-24 2015-01-27 H. Lundbeck A/S Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]-piperazine
SG178325A1 (en) 2009-08-24 2012-03-29 Lundbeck & Co As H New compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
CA2797812C (en) * 2010-04-30 2018-02-20 Takeda Pharmaceutical Company Limited Enteric tablet
MX341072B (es) * 2010-07-23 2016-08-05 Grünenthal Gmbh * Sales o co-cristales de 3-(3-dimetilamino-1-etil-2-metil-propil)-f enol.
TW201212918A (en) 2010-08-23 2012-04-01 Lundbeck & Co As H Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine
US9133144B2 (en) * 2012-01-03 2015-09-15 H. Lundbeck A/S Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
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