ATE540941T1 - 1-Ä2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYLÜPIPERAZ N AS A COMPOUND WITH COMBINED SEROTONIN REUPPOST, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE DISORDERS - Google Patents

1-Ä2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYLÜPIPERAZ N AS A COMPOUND WITH COMBINED SEROTONIN REUPPOST, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE DISORDERS

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Publication number
ATE540941T1
ATE540941T1 AT07764495T AT07764495T ATE540941T1 AT E540941 T1 ATE540941 T1 AT E540941T1 AT 07764495 T AT07764495 T AT 07764495T AT 07764495 T AT07764495 T AT 07764495T AT E540941 T1 ATE540941 T1 AT E540941T1
Authority
AT
Austria
Prior art keywords
reuppost
phenylüpiperaz
dimethylphenylsulfanyl
compound
treatment
Prior art date
Application number
AT07764495T
Other languages
German (de)
Inventor
Benny Bang-Andersen
Andre Faldt
Arne Myrk
De Diego Heidi Lopez
Rene Holm
Tine Bryan Stensbyl
Lone Munch Ringgaard
Michael J Mealy
Michael Harold Rock
Jorgen Brodersen
Morten Jyrgensen
Nicholas Moore
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39722479&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE540941(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE540941T1 publication Critical patent/ATE540941T1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Inorganic Chemistry (AREA)
AT07764495T 2006-06-16 2007-06-15 1-Ä2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYLÜPIPERAZ N AS A COMPOUND WITH COMBINED SEROTONIN REUPPOST, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE DISORDERS ATE540941T1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US80501406P 2006-06-16 2006-06-16
DKPA200600824 2006-06-16
US82666606P 2006-09-22 2006-09-22
DKPA200601223 2006-09-22
US86282606P 2006-10-25 2006-10-25
DKPA200601384 2006-10-25
DKPA200700427 2007-03-20
PCT/DK2007/050075 WO2007144005A1 (en) 2006-06-16 2007-06-15 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment

Publications (1)

Publication Number Publication Date
ATE540941T1 true ATE540941T1 (en) 2012-01-15

Family

ID=39722479

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07764495T ATE540941T1 (en) 2006-06-16 2007-06-15 1-Ä2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYLÜPIPERAZ N AS A COMPOUND WITH COMBINED SEROTONIN REUPPOST, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE DISORDERS

Country Status (31)

Country Link
US (13) US8722684B2 (en)
EP (2) EP2439201B1 (en)
JP (8) JP4590013B2 (en)
KR (3) KR101445514B1 (en)
CN (3) CN102614179B (en)
AR (1) AR061481A1 (en)
AT (1) ATE540941T1 (en)
AU (1) AU2007260355B2 (en)
BR (3) BR122020011920A2 (en)
CA (1) CA2655212C (en)
CL (1) CL2011001610A1 (en)
CY (1) CY1112635T1 (en)
DK (1) DK2044043T4 (en)
EA (1) EA015287B1 (en)
ES (2) ES2432102T3 (en)
FI (1) FI2044043T5 (en)
HR (1) HRP20120173T4 (en)
IL (1) IL195511A (en)
MA (1) MA30575B1 (en)
MX (1) MX2008016141A (en)
MY (1) MY150647A (en)
NO (1) NO343929B1 (en)
NZ (1) NZ572986A (en)
PL (1) PL2044043T5 (en)
PT (1) PT2044043E (en)
RS (1) RS52205B2 (en)
SI (1) SI2044043T2 (en)
TN (1) TNSN08460A1 (en)
TW (1) TWI443091B (en)
WO (1) WO2007144005A1 (en)
ZA (1) ZA200810017B (en)

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UA81749C2 (en) 2001-10-04 2008-02-11 Х. Луннбек А/С Derivated of phenylpiperazine as serotonin reuptake inhibitorS
JP7179035B2 (en) * 2006-06-16 2022-11-28 ハー・ルンドベック・アクチエゼルスカベット 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for treating cognitive impairment Piperazine
BR122020011920A2 (en) 2006-06-16 2020-08-25 Lundbeck & Co As H compound, pharmaceutical composition, method of treating a disease, use of a compound, and processes for preparing a compound, and for manufacturing a compound
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
TW200932233A (en) 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
AU2014200364B2 (en) * 2007-11-13 2015-09-17 H. Lundbeck A/S Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
GEP20135938B (en) * 2009-04-24 2013-10-10 H Lundbeck As Liquid pharmaceutical formulations of 1-[2-(2,4-dimethylsulfanyl)phenyl]piperazine
MX2012002199A (en) * 2009-08-24 2012-03-16 Lundbeck & Co As H New compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]pip erazine.
WO2011136376A1 (en) * 2010-04-30 2011-11-03 武田薬品工業株式会社 Enteric tablet
PL3650439T3 (en) * 2010-07-23 2021-06-28 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
TW201212918A (en) 2010-08-23 2012-04-01 Lundbeck & Co As H Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine
LT2800746T (en) * 2012-01-03 2019-06-10 H. Lundbeck A/S Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
US9713594B2 (en) * 2012-09-11 2017-07-25 Bend Research, Inc. Methods for making pharmaceutical solid dosage forms of spray-dried dispersions
CN104797566B (en) * 2012-09-19 2017-07-07 桑多斯股份公司 New crystalline form of vortioxetine hydrobromide
CN104853755B (en) * 2012-12-13 2017-08-22 H.隆德贝克有限公司 Composition comprising Vortioxetine and donepezil
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