CN103788019A - 沃替西汀的制备方法 - Google Patents
沃替西汀的制备方法 Download PDFInfo
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- CN103788019A CN103788019A CN201410028211.6A CN201410028211A CN103788019A CN 103788019 A CN103788019 A CN 103788019A CN 201410028211 A CN201410028211 A CN 201410028211A CN 103788019 A CN103788019 A CN 103788019A
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- BJHMYQKFVFJZDC-UHFFFAOYSA-N Cc(cc(C)cc1)c1Sc(cccc1)c1N Chemical compound Cc(cc(C)cc1)c1Sc(cccc1)c1N BJHMYQKFVFJZDC-UHFFFAOYSA-N 0.000 description 1
- SHBWPKLGXVSPIP-UHFFFAOYSA-N Cc(cc1)cc(C)c1Sc1ccccc1[N+]([O-])=O Chemical compound Cc(cc1)cc(C)c1Sc1ccccc1[N+]([O-])=O SHBWPKLGXVSPIP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201410028211.6A CN103788019B (zh) | 2014-01-22 | 2014-01-22 | 沃替西汀的制备方法 |
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CN201410028211.6A CN103788019B (zh) | 2014-01-22 | 2014-01-22 | 沃替西汀的制备方法 |
Publications (2)
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CN103788019A true CN103788019A (zh) | 2014-05-14 |
CN103788019B CN103788019B (zh) | 2015-10-07 |
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CN201410028211.6A Active CN103788019B (zh) | 2014-01-22 | 2014-01-22 | 沃替西汀的制备方法 |
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CN (1) | CN103788019B (zh) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104130212A (zh) * | 2014-07-01 | 2014-11-05 | 安徽省逸欣铭医药科技有限公司 | 一种适合氢溴酸沃替西汀工业化生产的合成方法 |
CN104447622A (zh) * | 2014-11-28 | 2015-03-25 | 郑州大明药物科技有限公司 | 氢溴酸沃替西汀β晶型的制备新方法 |
CN104725335A (zh) * | 2014-11-28 | 2015-06-24 | 郑州大明药物科技有限公司 | 高纯度氢溴酸沃替西汀的制备方法 |
WO2015114395A1 (en) | 2014-01-31 | 2015-08-06 | Egis Gyógyszergyár Zrt. | Process for the preparation of vortioxetine salts |
CN105348220A (zh) * | 2015-11-10 | 2016-02-24 | 山东川成医药股份有限公司 | 一种氢溴酸沃替西汀的合成方法 |
WO2016079751A3 (en) * | 2014-11-17 | 2016-07-14 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
WO2016151328A1 (en) | 2015-03-26 | 2016-09-29 | Cipla Limited | Method for making serotonin reuptake inhibitors |
CN107501209A (zh) * | 2016-06-14 | 2017-12-22 | 江苏吉贝尔药业股份有限公司 | 4‑[2‑(2‑甲基‑4‑溴‑苯巯基)‑苯基]哌嗪‑1‑羧酸叔丁酯合成方法 |
CN107513048A (zh) * | 2016-06-17 | 2017-12-26 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
CN108341793A (zh) * | 2017-01-25 | 2018-07-31 | 江苏吉贝尔药业股份有限公司 | 4-[2-(2-甲基-4-三氘甲基-苯巯基)-苯基]哌嗪氢溴酸盐新晶型及制备方法 |
US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
CN111320592A (zh) * | 2018-12-17 | 2020-06-23 | 天津理工大学 | 一种1-[2-(2,4-二甲基苯硫基)-苯基]哌嗪的制备方法 |
CN114957058A (zh) * | 2022-06-30 | 2022-08-30 | 杭州师范大学 | 一种硫醚类化合物的合成方法及应用 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2014471A3 (cs) * | 2014-07-08 | 2016-01-20 | Zentiva, K.S. | Způsob přípravy vortioxetinu |
Citations (7)
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---|---|---|---|---|
WO2003029232A1 (en) * | 2001-10-04 | 2003-04-10 | H. Lundbeck A/S | Phenyl-piperazine derivatives as serotonin reuptake inhibitors |
US20060154914A1 (en) * | 2004-12-09 | 2006-07-13 | Roche Palo Alto Llc | Dibenzoxazepinone derivatives and uses thereof |
WO2007144005A1 (en) * | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
WO2009062517A1 (en) * | 2007-11-13 | 2009-05-22 | H. Lundbeck A/S | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity |
WO2010094285A1 (en) * | 2009-02-17 | 2010-08-26 | H. Lundbeck A/S | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
CN102741226A (zh) * | 2009-10-30 | 2012-10-17 | 詹森药业有限公司 | 4-取代的-2-苯氧基-苯胺δ阿片类受体调节剂 |
WO2013102573A1 (en) * | 2012-01-03 | 2013-07-11 | H. Lundbeck A/S | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
-
2014
- 2014-01-22 CN CN201410028211.6A patent/CN103788019B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003029232A1 (en) * | 2001-10-04 | 2003-04-10 | H. Lundbeck A/S | Phenyl-piperazine derivatives as serotonin reuptake inhibitors |
US20060154914A1 (en) * | 2004-12-09 | 2006-07-13 | Roche Palo Alto Llc | Dibenzoxazepinone derivatives and uses thereof |
WO2007144005A1 (en) * | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
WO2009062517A1 (en) * | 2007-11-13 | 2009-05-22 | H. Lundbeck A/S | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity |
WO2010094285A1 (en) * | 2009-02-17 | 2010-08-26 | H. Lundbeck A/S | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
CN102741226A (zh) * | 2009-10-30 | 2012-10-17 | 詹森药业有限公司 | 4-取代的-2-苯氧基-苯胺δ阿片类受体调节剂 |
WO2013102573A1 (en) * | 2012-01-03 | 2013-07-11 | H. Lundbeck A/S | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
Non-Patent Citations (4)
Title |
---|
BENNY BANG-ANDERSEN ET AL: "Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (LuAA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 54, no. 9, 12 April 2011 (2011-04-12) * |
刑其毅 等: "《基础有机化学》", 30 November 1993, 高等教育出版社, article "基础有机化学", pages: 648-649 * |
史少辉 等: "硫醚合成研究进展", 《广州化工》, vol. 40, no. 6, 23 March 2012 (2012-03-23), pages 1 - 4 * |
李丽娟 等: "《药物合成反应技术》", 31 July 2007, 化学工业出版社, article "药物合成反应技术", pages: 43 * |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA029060B1 (ru) * | 2014-01-31 | 2018-02-28 | Эгиш Дьёдьсердьяр Зрт. | Способ получения солей вортиоксетина |
WO2015114395A1 (en) | 2014-01-31 | 2015-08-06 | Egis Gyógyszergyár Zrt. | Process for the preparation of vortioxetine salts |
CN106103418A (zh) * | 2014-01-31 | 2016-11-09 | 埃吉斯药物私人有限公司 | 沃替西汀盐的制备方法 |
US9822086B2 (en) | 2014-01-31 | 2017-11-21 | Egis Gyogyszergyar Zrt. | Process for the preparation of vortioxetine salts |
CN104130212A (zh) * | 2014-07-01 | 2014-11-05 | 安徽省逸欣铭医药科技有限公司 | 一种适合氢溴酸沃替西汀工业化生产的合成方法 |
CN104130212B (zh) * | 2014-07-01 | 2016-08-24 | 安徽省逸欣铭医药科技有限公司 | 一种适合氢溴酸沃替西汀工业化生产的合成方法 |
WO2016079751A3 (en) * | 2014-11-17 | 2016-07-14 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
CN104447622A (zh) * | 2014-11-28 | 2015-03-25 | 郑州大明药物科技有限公司 | 氢溴酸沃替西汀β晶型的制备新方法 |
CN104725335A (zh) * | 2014-11-28 | 2015-06-24 | 郑州大明药物科技有限公司 | 高纯度氢溴酸沃替西汀的制备方法 |
CN104725335B (zh) * | 2014-11-28 | 2017-03-08 | 郑州大明药物科技有限公司 | 高纯度氢溴酸沃替西汀的制备方法 |
WO2016151328A1 (en) | 2015-03-26 | 2016-09-29 | Cipla Limited | Method for making serotonin reuptake inhibitors |
CN105348220A (zh) * | 2015-11-10 | 2016-02-24 | 山东川成医药股份有限公司 | 一种氢溴酸沃替西汀的合成方法 |
CN107501209A (zh) * | 2016-06-14 | 2017-12-22 | 江苏吉贝尔药业股份有限公司 | 4‑[2‑(2‑甲基‑4‑溴‑苯巯基)‑苯基]哌嗪‑1‑羧酸叔丁酯合成方法 |
CN107513048A (zh) * | 2016-06-17 | 2017-12-26 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
CN107513048B (zh) * | 2016-06-17 | 2020-07-14 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
CN108341793A (zh) * | 2017-01-25 | 2018-07-31 | 江苏吉贝尔药业股份有限公司 | 4-[2-(2-甲基-4-三氘甲基-苯巯基)-苯基]哌嗪氢溴酸盐新晶型及制备方法 |
US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
CN111320592A (zh) * | 2018-12-17 | 2020-06-23 | 天津理工大学 | 一种1-[2-(2,4-二甲基苯硫基)-苯基]哌嗪的制备方法 |
CN114957058A (zh) * | 2022-06-30 | 2022-08-30 | 杭州师范大学 | 一种硫醚类化合物的合成方法及应用 |
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Effective date of registration: 20201015 Address after: 215600 station 0002, 20th floor, building A-1, shazhouhu science and Technology Innovation Park, Huachang Road, yangshe Town, Zhangjiagang City, Suzhou City, Jiangsu Province (cluster registration) Patentee after: Youbiao e-commerce (Suzhou) Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. Patentee before: Xu Xuenong |
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