CN104262232A - 尼泰达尼的制备方法 - Google Patents
尼泰达尼的制备方法 Download PDFInfo
- Publication number
- CN104262232A CN104262232A CN201410455826.7A CN201410455826A CN104262232A CN 104262232 A CN104262232 A CN 104262232A CN 201410455826 A CN201410455826 A CN 201410455826A CN 104262232 A CN104262232 A CN 104262232A
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- CN
- China
- Prior art keywords
- methyl
- taidani
- preparation
- base
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (8)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410455826.7A CN104262232B (zh) | 2014-09-09 | 2014-09-09 | 尼泰达尼的制备方法 |
PCT/CN2015/085719 WO2016037514A1 (zh) | 2014-09-09 | 2015-07-31 | 尼泰达尼的制备方法 |
US15/453,892 US9856215B2 (en) | 2014-09-09 | 2017-03-08 | Preparation method of Nintedanib |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410455826.7A CN104262232B (zh) | 2014-09-09 | 2014-09-09 | 尼泰达尼的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104262232A true CN104262232A (zh) | 2015-01-07 |
CN104262232B CN104262232B (zh) | 2016-05-04 |
Family
ID=52153851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410455826.7A Active CN104262232B (zh) | 2014-09-09 | 2014-09-09 | 尼泰达尼的制备方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US9856215B2 (zh) |
CN (1) | CN104262232B (zh) |
WO (1) | WO2016037514A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016037514A1 (zh) * | 2014-09-09 | 2016-03-17 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
CN106841495A (zh) * | 2017-04-21 | 2017-06-13 | 常州佳德医药科技有限公司 | 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法 |
WO2018068733A1 (zh) * | 2016-10-12 | 2018-04-19 | 浙江华海药业股份有限公司 | 尼达尼布及其中间体的制备方法 |
CN108610308A (zh) * | 2016-12-09 | 2018-10-02 | 上海奥博生物医药技术有限公司 | 一锅法制备尼达尼布中间体的方法 |
CN110072849A (zh) * | 2017-03-14 | 2019-07-30 | 新源生物科技股份有限公司 | 3-z-[1-(4-(n-((4-甲基-哌嗪-1-基)-甲羰基)-n-甲基-氨基)-苯氨基)-1-苯基-亚甲基]-6-甲氧羰基-2-吲哚满酮的晶型 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107935909B (zh) * | 2016-10-13 | 2023-03-17 | 上海科胜药物研发有限公司 | 一种尼达尼布(nintedanib)及其中间体的合成方法 |
CA3082714A1 (en) | 2017-11-17 | 2019-05-23 | Fermion Oy | Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib |
US11814428B2 (en) | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1391557A (zh) * | 1999-10-13 | 2003-01-15 | 贝林格尔英格海姆法玛公司 | 6-位取代的吲哚满酮,其制备及其作为药物组合物的用途 |
CN101166723A (zh) * | 2005-04-28 | 2008-04-23 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的新颖化合物 |
CN101883756A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 制备二氢吲哚酮衍生物的方法 |
CN101883755A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 二氢吲哚酮衍生物及其制备方法 |
WO2012068441A2 (en) * | 2010-11-19 | 2012-05-24 | Ratiopharm Gmbh | Intedanib salts and solid state forms thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104262232B (zh) * | 2014-09-09 | 2016-05-04 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
-
2014
- 2014-09-09 CN CN201410455826.7A patent/CN104262232B/zh active Active
-
2015
- 2015-07-31 WO PCT/CN2015/085719 patent/WO2016037514A1/zh active Application Filing
-
2017
- 2017-03-08 US US15/453,892 patent/US9856215B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1391557A (zh) * | 1999-10-13 | 2003-01-15 | 贝林格尔英格海姆法玛公司 | 6-位取代的吲哚满酮,其制备及其作为药物组合物的用途 |
CN101166723A (zh) * | 2005-04-28 | 2008-04-23 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的新颖化合物 |
CN101883756A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 制备二氢吲哚酮衍生物的方法 |
CN101883755A (zh) * | 2007-12-03 | 2010-11-10 | 贝林格尔.英格海姆国际有限公司 | 二氢吲哚酮衍生物及其制备方法 |
WO2012068441A2 (en) * | 2010-11-19 | 2012-05-24 | Ratiopharm Gmbh | Intedanib salts and solid state forms thereof |
Non-Patent Citations (3)
Title |
---|
GERALD J. ROTH,等: "Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)", 《J. MED. CHEM.》 * |
孙敏,等: "抗肿瘤候选新药intedanib的合成", 《中国医药工业杂志》 * |
戚建军,等: "司帕沙星的合成工艺研究", 《中国医药工业杂志》 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016037514A1 (zh) * | 2014-09-09 | 2016-03-17 | 苏州明锐医药科技有限公司 | 尼泰达尼的制备方法 |
US9856215B2 (en) | 2014-09-09 | 2018-01-02 | Suzhou Mirapharma Technology Co., Ltd. | Preparation method of Nintedanib |
WO2018068733A1 (zh) * | 2016-10-12 | 2018-04-19 | 浙江华海药业股份有限公司 | 尼达尼布及其中间体的制备方法 |
CN109803954A (zh) * | 2016-10-12 | 2019-05-24 | 浙江华海药业股份有限公司 | 尼达尼布及其中间体的制备方法 |
US10836751B2 (en) | 2016-10-12 | 2020-11-17 | Zhejiang Huahai Pharmaceutical Co., Ltd. | Methods for preparing Nintedanib and intermediates thereof |
CN109803954B (zh) * | 2016-10-12 | 2021-12-07 | 浙江华海药业股份有限公司 | 尼达尼布及其中间体的制备方法 |
CN108610308A (zh) * | 2016-12-09 | 2018-10-02 | 上海奥博生物医药技术有限公司 | 一锅法制备尼达尼布中间体的方法 |
CN110072849A (zh) * | 2017-03-14 | 2019-07-30 | 新源生物科技股份有限公司 | 3-z-[1-(4-(n-((4-甲基-哌嗪-1-基)-甲羰基)-n-甲基-氨基)-苯氨基)-1-苯基-亚甲基]-6-甲氧羰基-2-吲哚满酮的晶型 |
CN106841495A (zh) * | 2017-04-21 | 2017-06-13 | 常州佳德医药科技有限公司 | 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2016037514A1 (zh) | 2016-03-17 |
CN104262232B (zh) | 2016-05-04 |
US20170174625A1 (en) | 2017-06-22 |
US9856215B2 (en) | 2018-01-02 |
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Effective date of registration: 20201016 Address after: 215600 station 0002, 20th floor, building A-1, shazhouhu science and Technology Innovation Park, Huachang Road, yangshe Town, Zhangjiagang City, Suzhou City, Jiangsu Province (cluster registration) Patentee after: Youbiao e-commerce (Suzhou) Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. Patentee before: Xu Xuenong |