JP6461118B2 - ブロモドメイン阻害剤としての新規の置換された二環式化合物 - Google Patents
ブロモドメイン阻害剤としての新規の置換された二環式化合物 Download PDFInfo
- Publication number
- JP6461118B2 JP6461118B2 JP2016520759A JP2016520759A JP6461118B2 JP 6461118 B2 JP6461118 B2 JP 6461118B2 JP 2016520759 A JP2016520759 A JP 2016520759A JP 2016520759 A JP2016520759 A JP 2016520759A JP 6461118 B2 JP6461118 B2 JP 6461118B2
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- Prior art keywords
- benzo
- imidazol
- methyl
- dimethylisoxazol
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **c1cc(*)cc2c1nc(*)[n]2 Chemical compound **c1cc(*)cc2c1nc(*)[n]2 0.000 description 13
- FEKWWZCCJDUWLY-UHFFFAOYSA-N Cc1c[nH]cc1 Chemical compound Cc1c[nH]cc1 FEKWWZCCJDUWLY-UHFFFAOYSA-N 0.000 description 2
- SOHMZGMHXUQHGE-UHFFFAOYSA-N CC(C=C1)=CNC1=O Chemical compound CC(C=C1)=CNC1=O SOHMZGMHXUQHGE-UHFFFAOYSA-N 0.000 description 1
- MVKDNXIKAWKCCS-UHFFFAOYSA-N CC1=CC=CNC1=O Chemical compound CC1=CC=CNC1=O MVKDNXIKAWKCCS-UHFFFAOYSA-N 0.000 description 1
- QOEUNLQGZBSTBB-UHFFFAOYSA-N CN(CC1)C1=O Chemical compound CN(CC1)C1=O QOEUNLQGZBSTBB-UHFFFAOYSA-N 0.000 description 1
- GGYVTHJIUNGKFZ-UHFFFAOYSA-N CN(CCCC1)C1=O Chemical compound CN(CCCC1)C1=O GGYVTHJIUNGKFZ-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- AUGPQVPSNGKVJD-UHFFFAOYSA-N Cc(cc1)c[n]2c1nnc2 Chemical compound Cc(cc1)c[n]2c1nnc2 AUGPQVPSNGKVJD-UHFFFAOYSA-N 0.000 description 1
- GFJGRNOOYAKHNX-UHFFFAOYSA-N Cc(cc1)cc2c1[s]nc2 Chemical compound Cc(cc1)cc2c1[s]nc2 GFJGRNOOYAKHNX-UHFFFAOYSA-N 0.000 description 1
- OSRARURJYPOUOV-UHFFFAOYSA-N Cc(cc1)cc2c1nccn2 Chemical compound Cc(cc1)cc2c1nccn2 OSRARURJYPOUOV-UHFFFAOYSA-N 0.000 description 1
- HUVAAOZUPLEYBH-UHFFFAOYSA-N Cc1c(C)[nH]nc1C Chemical compound Cc1c(C)[nH]nc1C HUVAAOZUPLEYBH-UHFFFAOYSA-N 0.000 description 1
- SUHBKHNLQCODJL-UHFFFAOYSA-N Cc1c(C)[n](C)nc1 Chemical compound Cc1c(C)[n](C)nc1 SUHBKHNLQCODJL-UHFFFAOYSA-N 0.000 description 1
- DUAZFYUNWBILMU-UHFFFAOYSA-N Cc1c(C)[n](C)nc1C Chemical compound Cc1c(C)[n](C)nc1C DUAZFYUNWBILMU-UHFFFAOYSA-N 0.000 description 1
- BAMPVSWRQZNDQC-UHFFFAOYSA-N Cc1c(C)[s]c(C)n1 Chemical compound Cc1c(C)[s]c(C)n1 BAMPVSWRQZNDQC-UHFFFAOYSA-N 0.000 description 1
- RIKMMFOAQPJVMX-UHFFFAOYSA-N Cc1c[nH]nc1 Chemical compound Cc1c[nH]nc1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 1
- GHGZGDGWFWIAQM-UHFFFAOYSA-N Cc1c[n](C)nc1C Chemical compound Cc1c[n](C)nc1C GHGZGDGWFWIAQM-UHFFFAOYSA-N 0.000 description 1
- KJRRQXYWFQKJIP-UHFFFAOYSA-N Cc1c[o]cc1 Chemical compound Cc1c[o]cc1 KJRRQXYWFQKJIP-UHFFFAOYSA-N 0.000 description 1
- VHWFNFITHSPBSR-UHFFFAOYSA-N Cc1c[o]nc1 Chemical compound Cc1c[o]nc1 VHWFNFITHSPBSR-UHFFFAOYSA-N 0.000 description 1
- QENGPZGAWFQWCZ-UHFFFAOYSA-N Cc1c[s]cc1 Chemical compound Cc1c[s]cc1 QENGPZGAWFQWCZ-UHFFFAOYSA-N 0.000 description 1
- YUTQRQJTFPEEPB-UHFFFAOYSA-N Cc1c[s]nc1 Chemical compound Cc1c[s]nc1 YUTQRQJTFPEEPB-UHFFFAOYSA-N 0.000 description 1
- OLICQMSZRKFIIN-UHFFFAOYSA-N Cc1c[s]nc1C Chemical compound Cc1c[s]nc1C OLICQMSZRKFIIN-UHFFFAOYSA-N 0.000 description 1
- GHPODDMCSOYWNE-UHFFFAOYSA-N Cc1ccc2OCOc2c1 Chemical compound Cc1ccc2OCOc2c1 GHPODDMCSOYWNE-UHFFFAOYSA-N 0.000 description 1
- UBIAVBGIRDRQLD-UHFFFAOYSA-N Cc1ccc2[o]cnc2c1 Chemical compound Cc1ccc2[o]cnc2c1 UBIAVBGIRDRQLD-UHFFFAOYSA-N 0.000 description 1
- SEBIXVUYSFOUEL-UHFFFAOYSA-N Cc1ccc2[s]cnc2c1 Chemical compound Cc1ccc2[s]cnc2c1 SEBIXVUYSFOUEL-UHFFFAOYSA-N 0.000 description 1
- QPUYECUOLPXSFR-UHFFFAOYSA-N Cc1cccc2c1cccc2 Chemical compound Cc1cccc2c1cccc2 QPUYECUOLPXSFR-UHFFFAOYSA-N 0.000 description 1
- QZVSMTWHHPOUKN-UHFFFAOYSA-N Cc1cccc2c1cn[n]2C Chemical compound Cc1cccc2c1cn[n]2C QZVSMTWHHPOUKN-UHFFFAOYSA-N 0.000 description 1
- IEZFKBBOGATCFW-UHFFFAOYSA-N Cc1cccc2c1cncc2 Chemical compound Cc1cccc2c1cncc2 IEZFKBBOGATCFW-UHFFFAOYSA-N 0.000 description 1
- LSZQMSSIUQNTDX-UHFFFAOYSA-N Cc1ccn[n]1C Chemical compound Cc1ccn[n]1C LSZQMSSIUQNTDX-UHFFFAOYSA-N 0.000 description 1
- CAWHJQAVHZEVTJ-UHFFFAOYSA-N Cc1cnccn1 Chemical compound Cc1cnccn1 CAWHJQAVHZEVTJ-UHFFFAOYSA-N 0.000 description 1
- TWGNOYAGHYUFFR-UHFFFAOYSA-N Cc1cncnc1 Chemical compound Cc1cncnc1 TWGNOYAGHYUFFR-UHFFFAOYSA-N 0.000 description 1
- CUMCMYMKECWGHO-UHFFFAOYSA-N Cc1n[o]cc1 Chemical compound Cc1n[o]cc1 CUMCMYMKECWGHO-UHFFFAOYSA-N 0.000 description 1
- WOTIUKDGJBXFLG-UHFFFAOYSA-N Cc1n[s]cc1 Chemical compound Cc1n[s]cc1 WOTIUKDGJBXFLG-UHFFFAOYSA-N 0.000 description 1
- NNXBSBHTRNCQQS-UHFFFAOYSA-N Ic1nnccc1 Chemical compound Ic1nnccc1 NNXBSBHTRNCQQS-UHFFFAOYSA-N 0.000 description 1
- LSROBYZLBGODRN-UHFFFAOYSA-N NN(CCC1)C1=O Chemical compound NN(CCC1)C1=O LSROBYZLBGODRN-UHFFFAOYSA-N 0.000 description 1
Classifications
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| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. | ブロモドメイン阻害剤としての新規複素環式化合物 |
| EA035469B1 (ru) | 2013-03-15 | 2020-06-22 | Инсайт Холдингс Корпорейшн | Трициклические гетероциклы как ингибиторы белков бэт |
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