JP6407111B2 - 腫瘍細胞を検出するための装置 - Google Patents
腫瘍細胞を検出するための装置 Download PDFInfo
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Description
本願は、2011年5月5日出願の米国特許出願シリアル番号61/482,900の優先権を主張し、その内容全体を参照によって援用する。
装置のある態様では、前処理ユニットは、試料濾過ユニット、補給ユニット、定圧配達ユニット、試料擾乱ユニット、または試料前プロービング擾乱ユニットを備える。前活性化ユニットは、関心のある物質(癌細胞など)の収縮比を増加させ、したがって装置が、標的生体被検体(癌細胞など)を検出するのに、より有効かつ効率的となり、非常に低いレベルの関心のある生体被検体(例えば濃度が10億〜100億のうちの一部分であるCTCといった癌または腫瘍細胞など)検出には特に有益である。
他の実施形態
本発明を、詳細な説明および添付の図面を用いて説明したが、上記の説明および添付の図面は例示のためのものであり、本発明の範囲を限定するものではなく、添付の特許請求の範囲によって定義されることは理解されよう。他の態様、利点および変更は、特許請求の範囲によって定義される範囲に含まれる。ここに引用したすべての参照は、その全体が参照によって援用される。
Claims (20)
- 生体被検体と相互作用し生体被検体内の循環腫瘍細胞を検出するための装置であって、
生体被検体に信号を送信し、生物学的実体から前記信号に対する応答を選択的に受信するための一のデバイスと、
生体被験体が移動するウェルと、前記ウェルを閉鎖可能に構成される時間シャッタと、生体被験体が前記ウェルを通って移動すると前記時間シャッタのクロックを生成するカウンタと、を含み、所定速度以上の特定の生体被検体だけが前記ウェルを通過するように前記時間シャッタが前記ウェルを閉鎖する、マイクロフィルタを具備する濾過ユニットを有する前処理ユニットと、
廃棄生体試料を回収するとともに、環境汚染を防ぐ廃棄物回収処理ユニットと、
を備える装置。 - 請求項1に記載の装置であって、生体被検体との相互作用は、生体被検体の電気的特性のプロービング、検出、または、分析である装置。
- 請求項1に記載の装置であって、前記デバイスは、細胞の面上にまたは細胞内に一の要素または要素の組み合わせを蓄積させるまたは放出させる第一構成要素と、要素の放出を制御するための第二構成要素と、を備える装置。
- 請求項3に記載の装置であって、第二構成要素は、要素の放出を制御するための回路である装置。
- 請求項1に記載の装置であって、前記信号は、放出された要素、または要素の組み合わせの態様である装置。
- 請求項5に記載の装置であって、前記信号は、溶液、気体またはその組み合わせよって運ばれる装置。
- 請求項1に記載の装置であって、前記信号は、パルス状の信号または一定の信号である装置。
- 請求項1に記載の装置であって、前記信号の周波数は1×10−4Hz〜100MHzの範囲である装置。
- 請求項1に記載の装置であって、前記生物学的実体からの応答が、電気的特性で構成される装置。
- 請求項1に記載の装置であって、生物学的実体からの応答は、振動周波数の応答である装置。
- 請求項1に記載の装置であって、前記デバイスは生物学的に適合した膜で被覆される装置。
- 請求項1に記載の装置であって、前記デバイスは、前記生物学的実体へ送信すべき信号を生成する構成要素、前記生物学的実体からの信号に対する応答を受信する構成要素、応答を分析する構成要素、応答を処理する構成要素、前記デバイスと前記生物学的実体の間を接続する構成要素、前記生物学的実体と通信する構成要素、前記生物学的実体のある様相を変更する構成要素、または前記生物学的実体のある様相を修正する構成要素、を備える装置。
- 請求項1に記載の装置であって、前記デバイスはプローブを備えており、プローブは生体被検体を移動させることができる装置。
- 請求項13に記載の装置であって、プローブは、生体被検体を移動させるために、プローブを拡張または収縮するための柔軟な支持構造を備える装置。
- 請求項1に記載の装置であって、前記デバイスはプローブを備えており、装置におけるプローブは制御回路に接続される装置。
- 請求項1に記載の装置であって、生体被検体は、血液試料、リンパ球試料、骨髄試料、尿試料、唾液試料、涙液試料、汗試料、リンパ試料、またはその処理された溶液である装置。
- 請求項1の装置であって、さらに、生体被検体を送達するためのユニット、チャネル、補給ユニット、検出ユニット、データ記憶ユニット、データ分析ユニット、中央制御ユニット、生体試料再循環ユニット、地球測位システム、運動デバイス、信号送信器、信号受信器、センサ、論理処理ユニット、アプリケーション専用チップ、マイクロ電気機械デバイス、多機能デバイス、または手術、ドラッグデリバリー、洗浄もしくは医療機能を実行するマイクロ器具、を備える装置。
- 請求項1に記載の装置であって、前記前処理ユニットは、栄養呼吸気体補給ユニット、定圧送達ユニット、または試料擾乱ユニットをさらに備える装置。
- 請求項17に記載の装置であって、装置は単一デバイスに集積されるまたは基板上に組み付けられる装置。
- 請求項1に記載の装置であって、腫瘍細胞は、前立腺癌、肺癌、結腸癌、乳癌、脳腫瘍、子宮頸癌、ホジキンリンパ腫、非ホジキンリンパ腫、腎臓癌、白血病、肝臓癌、卵巣癌、皮膚癌、睾丸癌、甲状腺癌、膵臓癌、子宮内膜癌、食道癌または子宮癌である装置。
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